Select aging biomarkers based on telomere length and chronological age to build a biological age equation

Zhang, Weiguang; Zhu, Shuying; Bai, Xia; Zhao, Delong; Jiang, Shimin; Li, Juan; Li, Zuo-Xiang; Fu, Bo; Cai, Guangyan; Sun, Xuefeng; Chen, Xiangmei

doi:10.1007/s11357-014-9639-y

Cited by 65 publications

(89 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we did not have information on the changes in LTL. It should be pointed out that, to address the question of whether LTL can be used as a biomarker of age-related physical functioning decline, knowledge is needed on the changes in LTL, taking confounding factors into account, that take place across the life course (Zhang et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Sillanpää

Törmäkangas

Rantanen

et al. 2016

AGE

View full text Add to dashboard Cite

Leukocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11-year follow-up. Older mono-(MZ) and dizygotic (DZ) twin sisters (n = 386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3-and 11-year follow-ups. The baseline analysis was performed with path models, adjusted with age and within-pair dependence of twin pairs. The longitudinal analysis was performed with a repeated measures linear model adjusted for age and longitudinal within-pair dependence. A nonrandom missing data analysis was utilized. At baseline, in all individuals, LTL was associated with PA (est. 0.14, SE 0.06, p = 0.011), but not with walking distance. Over the follow-up, a borderline significant association was observed between LTL and walking distance (est. 0.14, SE 0.07, p = 0.060) and a significant association between LTL and PA (est. 0.19, SE 0.06, p = 0.001). The results suggest that LTL is associated with PA and may, therefore, serve as a biomarker predicting the development of disability. Longitudinal associations between LTL and PA were observed only when nonrandom data missingness was taken into account in the analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Sillanpää

Törmäkangas

Rantanen

et al. 2016

AGE

View full text Add to dashboard Cite

show abstract

“…Furthermore, BD individuals at different evolutionary stages of the illness may have different degrees of activation of immune pathways and O&NS (Berk et al, 2011). These pathophysiological mechanisms may contribute to telomere erosion (Zhang et al, 2014). Studies included in this meta-analysis enrolled BD patients with different clinical characteristics.…”

Section: Discussionmentioning

confidence: 99%

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Colpo¹,

Leffa

Köhler

et al. 2015

Journal of Affective Disorders

View full text Add to dashboard Cite

“…Many factors contribute to the ageing process, which may explain disparate findings in the literature. Prominent among these are leukocyte telomere length, CRP and serum cytokine levels (Zhang et al 2014). Short telomeres are negatively associated with longevity in the elderly and positively with diseases of ageing, such as atherosclerosis (Benetos et al 2013), cardiovascular events (Baragetti et al 2014) or dementia (Jenkins et al 2006).…”

Section: Introductionmentioning

confidence: 99%

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

et al. 2015

View full text Add to dashboard Cite

Hand-grip strength is strongly correlated with measures of muscle mass and can be taken to predict morbidity and mortality. The aim of this study was to investigate the relationship between hand-grip strength and other markers associated with immune ageing, such as Cytomegalovirus (CMV) infection, leukocyte telomere length and serum levels of inflammatory and anti-inflammatory markers in the elderly. We have assessed grip strength with the Smedley Dynamometer in younger (22-37 years) and older (60-85 years) men and women in a sample of people living in Berlin (the BASE-II study). Serum cytokine levels were determined by flow-cytometry, CMV serostatus via ELISA and leukocyte telomere length by quantitative PCR. IL-1β levels tended to be negatively associated with grip strength, but we did not find a significant association with IL-6 levels. CMV-seropositivity was not associated with higher levels of IL-1β, IL-6 or TNF, nor with weaker grip strength in men or women at any age. A putative general measure of organismal ageing, overall leukocyte telomere length, was also found not to be associated with lower grip strength in the elderly. Hand-grip strength remains an important biomarker independent of CMV infection or shorter telomere lengths, and poorly reflected in peripheral pro-inflammatory cytokine levels, all of which have been associated in some studies with frailty and mortality.

show abstract

Select aging biomarkers based on telomere length and chronological age to build a biological age equation

Cited by 65 publications

References 71 publications

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

Contact Info

Product

Resources

About