Microalgae are potential sources of biofuel production; however, cultivation high costs still makes the process impractical. In this way, the purpose of this article was to evaluate the microalgae production using wastewater as a culture alternative medium. The microalgae studied was Scenedesmus acuminatus, grown in Wright's Cryptophyte (WC) medium, under which different effluent concentrations were added to evaluate kinetic parameters, biomass and lipid yield and COD removals. It was found that the optimal concentration for developing these microalgae was 100% effluent in its medium. The COD removal was more efficient in the culture with 80% effluent reaching a reduction of 32.8%. The biomass of S. acuminatus cultivated with 100% effluent addition showed 10.42% of lipid production. The statistical methods indicated a strong correlation between the parameters specific growth rate, generation time and COD removal, since productivity showed moderate correlation with all parameters, except with the corresponding variable to COD removal. The insertion viability of effluents generated from anaerobic treatment of domestic sewage in microalgae cultivation was proven when it was detected an excellent adaptation and consequent microalgae growth after submitted to different proportions of the effluent in its culture.