Sekundäre maligne Neoplasien bei Patientinnen mit Mammakarzinom

Dörffel, W.; Reitzig, P; Dörffel, Yvonne; Possinger, K.

doi:10.1055/s-2000-10604

Cited by 10 publications

(13 citation statements)

References 10 publications

(14 reference statements)

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“…As an example, the cumulative incidence for patients with up to 30 years of follow-up after the diagnosis of Hodgkin's lymphoma (HL) was 4.4% for thyroid carcinoma and the mean interval after HL diagnosis was 13.2 years (range 4.0-29.2 years). The most frequent thyroid carcinoma identified in these patients is PTC (Dorffel et al 2000, Levy et al 2012. This pediatric thyroid cancer peak incidence and a 'latency phase' reinforce that a long-term follow-up of patients should be undertaken for survivors of both the Fukushima Daiichi Nuclear Power Plant accident and any cancer during childhood involving radiotherapy to the thorax or head and neck region.…”

Section: Risk Factorsmentioning

confidence: 93%

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Cordioli¹,

Moraes²,

Cury³

et al. 2015

Endocrine-Related Cancer

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Data from the National Cancer Institute and from the literature have disclosed an increasing incidence of thyroid cancer in children, adolescents and adults. Although children and adolescents with thyroid cancer tend to present with more advanced disease than adults, their overall survival rate is excellent; however, there is no clear explanation for the differences observed in the clinicopathological outcomes in these age groups. There has been an ongoing debate regarding whether the clinicopathological differences may be due to the existence of distinct genetic alterations. Efforts have been made to identify these acquired genetic abnormalities that will determine the tumor's biological behavior and ultimately allow molecular prognostication. However, most of the studies have been performed in radiation-exposed pediatric thyroid carcinoma. Therefore, our understanding of the role of these driver mutations in sporadic pediatric differentiated thyroid cancer development is far from complete, and additionally, there is a strong need for studies in both children and adolescents. The aim of this review is to present an extensive literature review with emphasis on the molecular differences between pediatric sporadic and radiation-exposed differentiated thyroid carcinomas and adult population. Key Words" sporadic pediatric papillary thyroid carcinomas " radiation-exposed papillary thyroid carcinomas " RET/PTC

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Section: Risk Factorsmentioning

confidence: 93%

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Cordioli¹,

Moraes²,

Cury³

et al. 2015

Endocrine-Related Cancer

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“…Among the 58 included studies, 4,360,723 patients were enrolled, with sample sizes ranging from 763 to 525,527 and publication years ranging from 1974 to 2021. In addition, 32, [18,21,28,33,35,36,38,39,41,[43][44][45][46][47][48][49][50][51]53,[55][56][57][58][59][60]62,64,67,68,70,72,75] 11, [28,29,32,42,52,55,59,61,65,71,74] 19, [18][19][20]23,[25][26][27][29]…”

Section: Basic Characteristics Of the Included Studiesmentioning

confidence: 99%

Increased risk of subsequent primary lung cancer among female hormone-related cancer patients: A meta-analysis based on over four million cases

Wang,

Song,

Wang

et al. 2024

Chinese Medical Journal

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Background: The incidence rate of lung cancer in women has significantly increased over the past decade, and previous evidence has indicated a significant relationship between the elevated levels of sex hormones and the risk of lung cancer. Therefore, we hypothesized that female hormone-related cancer (FHRC) patients, including breast, endometrial, cervical, and ovarian cancer patients, may experience a higher risk of developing subsequent lung cancer. This meta-analysis aimed to identify the risk of lung cancer among FHRC patients compared to the general population. Methods: The PubMed, Web of Science, EMBASE, Cochrane Library, and CNKI databases were searched up to May 11, 2022. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were used to identify the risk of subsequent lung cancer after FHRC. Subgroup analyses based on the follow-up time and tumor type were also conducted. Results: A total of 58 retrospective cohort studies involving 4,360,723 FHRC participants were included. The pooled results demonstrated that FHRC patients had a significantly increased risk of developing subsequent primary lung cancer (SIR = 1.61, 95% CI: 1.48–1.76, P <0.001). Subgroup analysis revealed an obvious trend of increasing lung cancer risk over time (SIRs for <5 years, ≥5 years, ≥10 years, ≥20 years, and ≥30 years after FHRC: 1.32, 1.59, 1.57, 1.68, and 1.95, respectively). In addition, subgroup analysis stratified by tumor type indicated an increased risk of developing subsequent lung cancer after breast (SIR = 1.25, P <0.001), endometrial (SIR = 1.40, P = 0.019), cervical (SIR = 2.56, P <0.001), and ovarian cancer (SIR = 1.50, P = 0.010). Conclusion: FHRC patients are more likely to develop lung cancer than the general population. Furthermore, the increased risk of subsequent primary lung cancer is more obvious with a longer survival time and is observed in all types of hormone-related cancer. Registration: International Platform of Registered Systematic Review and Meta-analysis Protocols: No. INPLASY202270044; https://inplasy.com/

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“…More than 80% of breast cancer patients are diagnosed at an age between 30 and 60 years old, and current evidence indicates that breast cancer patients tend to be younger than previously. 14,15 On the other hand, lung cancer is also more common in middle-aged and elderly people, and more than 85% of patients are over 45 years old. 16 A case-control study performed by Ford et al demonstrated that breast cancer patients younger than 50 years old were more likely to develop subsequent lung cancer than patients older than 50 [odds ratio (OR)=1.51, 95% CI: 1.07-2.14, P=0.048].…”

Section: Factors Influencing the Risk Of Subsequent Lung Cancer In Breast Cancer Patients Age At The Diagnosis Of Breast Cancermentioning

confidence: 99%

Primary Lung Cancer After Treatment for Breast Cancer

Qian¹,

Wang²,

Che³

2021

IJWH

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Breast cancer is the most common malignancy in women and the second most common cause of cancer-related death. Due to advances in the diagnosis and treatment technologies for breast cancer, patients with breast cancer are living longer than before, resulting in an increased risk of developing subsequent malignancies, among which lung cancer is the most common. This review presents the current evidence about the risk, influencing factors and prognostic factors of developing primary lung cancer after treatment for breast cancer. The aim is to help clinicians improve their understanding, diagnosis and treatment of lung cancer after breast cancer.

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Sekundäre maligne Neoplasien bei Patientinnen mit Mammakarzinom

Abstract: In proposing recommendations for the follow-up and management of women with breast cancer, it is important to recognize their long-term predisposition to an array of secondary cancers.

Cited by 10 publications

References 10 publications

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Increased risk of subsequent primary lung cancer among female hormone-related cancer patients: A meta-analysis based on over four million cases

Primary Lung Cancer After Treatment for Breast Cancer

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