Seizures in the Nigerian neonate: Perinatal factors

Omene, J. A.; Longe, Ade C.; Okolo, Angela A.

doi:10.1016/0020-7292(81)90078-3

Cited by 9 publications

(13 citation statements)

References 14 publications

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“…There was higher proportion of term babies with seizures compared to those without seizures in the present study. This was similar to the observations by other workers within [4][5][6][7][8] and outside Nigeria [9][10][11]. This might be related to the fact that term babies have more developed musculatures and better neuronal myelination than preterm babies hence they are more likely to present with clinically identifiable seizure activities.…”

Section: Discussionsupporting

confidence: 90%

“…Reports from developing countries though mostly hospital based [4][5][6][7][8] signify a high incidence of neonatal morbidity including seizures compared to that from developed countries [9][10][11]. Unfortunately, in most centers in developing countries where neonatal seizures as well as newborn morbidity and mortality are high, facilities to fully investigate, monitor and manage neonatal seizures are often inadequate [4][5][6][7][8]. Furthermore, resources and facilities to support and rehabilitate children manifesting with long term sequelae of neonatal seizures and its underlying causes are often also out of reach of many of the parents of these children [6].…”

Section: Introduction mentioning

confidence: 99%

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Factors associated with clinical seizures in high-risk neonates at the Wesley Guild hospital, Ilesa, Nigeria

2015

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The occurrence of seizures among ill newborns has been reported to increase morbidity and mortality. Recognition and prompt management/avoidance of risk factors associated with the occurrence of seizures in the newborn may improve survival. This study aims to determine the risk factors for seizures among admitted babies at the Wesley Guild hospital, Ilesa. Consecutive neonatal admissions over a 9 month period were prospectively observed for clinical seizures. Perinatal and neonatal factors were compared between babies with and without seizures. Multiple logistic regression analysis was used to determine the independent predictors of the occurrence of seizures among the babies. Fifty-five (16.2%) of the 340 neonates admitted during the study period had clinical seizures. Male to female ratio of babies with seizures was 2.9:1, and 67.2% were admitted within 72 h of birth. Male sex (odds ratio [OR] 2.256; 95% confidence interval [CI] 1.146?7.167; P=0.024), parental low socioeconomic class (OR=2.211; 95% CI=1.427?9.281; P=0.007), delivery outside the hospital, particularly in mission homes (OR=4.173; 95% CI=1.590?14.040; P=0.005), and maternity homes (OR=2.005; 95% CI=1.183?9.692; P=0.003) were the independent risk factors associated with seizures among the babies. Delivery in private maternity and mission homes coupled with parental low socioeconomic class are major risk factors for seizures among admitted sick babies at the Wesley Guild hospital, Ilesa. Making delivery in standard health centers easily accessible and affordable may help reduce this burden.

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Section: Discussionsupporting

confidence: 90%

Section: Introduction mentioning

confidence: 99%

Factors associated with clinical seizures in high-risk neonates at the Wesley Guild hospital, Ilesa, Nigeria

2015

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“…It was recognized in 5.6 per 1000 live births of the inborn infants at JUH during the study period. This figure is within the range of 1.8 to 8.6 per 1000 live births reported by previous studies [2][3][4][5][6]. This wide range can be attributed to the differences in the inclusion criteria, difficulties in seizures recognition and whether the study is hospital-based or population-based.…”

Section: Discussionsupporting

confidence: 73%

“…Seizures occur more frequently in the neonatal period than at any other time of life with an incidence of 1.8 to 8.6 per 1000 live births [1][2][3][4][5][6]. Neonatal seizures are non-specific responses of the immature brain to different insults.…”

Section: Introductionmentioning

confidence: 99%

Etiological and clinical profile of neonatal seizures in a highly consanguineous population

et al. 2015

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A prospective longitudinal study was conducted on all neonates admitted with a diagnosis of neonatal seizures in the neonatal intensive care unit of Jordan University Hospital Amman from April 2003 to March 2005 to examine the cause and clinical profile of seizures in a community, which culturally favors consanguineous marriages. Of 35 neonates studied, inborn errors of metabolism accounted for 28.6%, hypoxic ischemic encephalopathy for 17.1% and cerebral malformations for 14.3%. The consanguinity rate among parents of affected neonates was 54%, and 22.9% of these probands had a similarly affected sibling. Compared with 78 matched controls, consanguinity proved to be a risk factor for neonatal seizures (P=0.007, odds ratios =3.02; 95% confidence intervals 1.22 to 7.51). The hospital-based incidence of seizures was 5.6 per 1000 live births. Poor outcome in the form of mortality or morbidity was present in 67.8% of the cases. Early-onset seizures and status epilepticus accounted in 40% and 22.9% of cases respectively, with subtle seizures being the commonest type. Based on our results, inborn errors of metabolism and cerebral malformations make a significant contribution to the etiology of clinical neonatal seizures. This is accounted for by the consanguineous population being at risk for a number of neurogenetic disorders leading to convulsions on one hand and by improved methods of diagnosis of neonatal seizures on the other. In future, genetic counseling may help to minimize the contribution of underlying genetic factors to neonatal seizures in our community.

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“…[ 3 4 ] They, therefore, connote signs of poor prognosis particularly in resource-constraint regions where the facilities for adequate management of such babies are not readily available. [ 5 6 7 8 ]…”

Section: Introductionmentioning

confidence: 99%

Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria

2015

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Background:Neonatal seizures contribute significantly to newborn morbidity and mortality particularly in developing countries including Nigeria. Unfortunately the countries with high incidence of neonatal seizures often lack the facilities to adequately diagnose, monitor and prognosticate the condition.Objective:We set out to determine the factors at presentation that predict death among babies admitted with clinically identifiable seizures.Methods:We prospectively observed consecutive neonatal admissions over a nine month period at the Wesley Guild Hospital, Ilesa, Nigeria. Babies with seizures were identified based on clinical observation. Perinatal history, examination and laboratory findings were compared between babies with seizures who survived and those that died. Multivariate regression analysis was used to determine the predictors of mortality.Results:Over a nine month study period, a total of 340 babies were recruited out of which 55 (16.7 percent) had clinically identifiable seizures. Fifteen (27.3 percent) of the 55 babies with clinically identifiable seizures died; while 20 (7.0 percent) of the 285 babies without seizures died. Clinically identifiable neonatal seizures contributed to 42.9 percent of the overall mortality in the neonatal unit during the study period. The risk factors for mortality among the babies with seizures were clinical seizures in the first 24 hours of life, birth asphyxia co-existing with hyponatraemia and presence of cerebral oedema (P < 0.05). The independent determinant of mortality among babies with clinical seizures was cerebral oedema (OR = 4.025; 95% CI 1.342–26.956; P = 0.019).Conclusion:We conclude that clinically identifiable neonatal seizures contribute significantly to neonatal mortality and presentation within 24 hours of delivery, birth asphyxia and cerebral oedema increased the risk of death in babies with seizures.

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Seizures in the Nigerian neonate: Perinatal factors

Cited by 9 publications

References 14 publications

Factors associated with clinical seizures in high-risk neonates at the Wesley Guild hospital, Ilesa, Nigeria

Factors associated with clinical seizures in high-risk neonates at the Wesley Guild hospital, Ilesa, Nigeria

Etiological and clinical profile of neonatal seizures in a highly consanguineous population

Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria

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