Seizures due to high dose camphor ingestion

Tekin, Hande Gazeteci; Gökben, Sarenur; Serdaroğlu, Gül

doi:10.5152/turkpediatriars.2015.1360

Cited by 4 publications

(2 citation statements)

References 7 publications

(11 reference statements)

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“…Despite these records, little is known about this phenomenon. The results of the present study show clearly that camphor is capable of inducing tonic-clonic seizures in rats, with effects similar to those described in humans 8,9,12,15,18 . There are many types of seizure, which present different electroencephalographic patterns and behavioral correlates 20,21 .…”

Section: Discussionsupporting

confidence: 85%

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Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures

Ferreira

Souza

Silva

et al. 2020

Sci Rep

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Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In the present study, we investigated the electrocorticographic patterns of seizures induced by camphor in male adult Wistar rats. Each rat received 400 mg/kg (i.p.) of camphor prior to monitoring by electrocorticography. The application of camphor resulted a rapid evolution to seizure and marked changes in the electrocorticographic readings, which presented characteristics of epileptiform activity, with an increase in the total power wave. The decomposition of the cerebral waves revealed an increase in the delta and theta waves. The analysis of the camphor traces revealed severe ictal activity marked by an increase in the polyspike wave. Our data thus indicate that camphor may cause seizures, leading to tonic–clonic seizures. Clearly, further studies are necessary to better elucidate the mechanisms through which camphor acts on the brain, and to propose potential treatments with anticonvulsant drugs that are effective for the control of the seizures.

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Section: Discussionsupporting

confidence: 85%

“…There are many recorded cases of seizures induced by camphor, especially in children 9,12,[15][16][17][18][19] . Despite these records, little is known about this phenomenon.…”

Section: Discussionmentioning

confidence: 99%