Seizures complicating infantile and childhood bacterial meningitis

Chang, Chin-Jung; Chang, Hsueh‐Wen; Chang, Wen-Neng; Huang, Laura; Huang, Song‐Chei; Chang, Ying-Chao; Hung, Po-Cheng; Chang, Chen-Sheng; Chuang, Yao-Chung; Huang, Chaoran; Tsai, Nai‐Wen; Tsui, Huan-Wen; Wang, Kuo-Wei; Lu, Cheng-Hsien

doi:10.1016/j.pediatrneurol.2004.03.009

Cited by 37 publications

(33 citation statements)

References 20 publications

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“…24 In one study of H. influenzae meningitis, 50% of the patients who presented with seizures at the time of admission went on to die or to have major neurological sequelae. 28 Low GCS (<8) and focal nerve deficits at the time of acute illness were independent predictors of sequelae in this study; which is similar to some published data on neurological sequelae. 29,30 A study from Africa 29 has reported that young age, unarousable coma, focal nerve deficits, abnormal posturing and abnormal muscle tone were associated with significantly increased risk of sequelae.…”

Section: Discussionsupporting

confidence: 90%

Predictors of long term neurological outcome in bacterial meningitis

et al. 2007

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Section: Discussionsupporting

confidence: 90%

Predictors of long term neurological outcome in bacterial meningitis

et al. 2007

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“…Seizures following bacterial meningitis are commonly of the focal-onset type with or without secondary generalization, though generalized seizures and myoclonic seizures may also occur (Rosman et al, 1985;Annegers et al, 1988;Pomeroy et al, 1990;Chang et al, 2004). In the Olmsted County study, the risk of focal-onset seizures after any CNS infection was increased 12-fold, while that of generalized-onset seizures was increased three-fold (Annegers et al, 1988).…”

Section: Seizure Semiology Course and Prognosismentioning

confidence: 98%

“…A limited number of studies have examined risk factors that predispose to the development of a late unprovoked seizure or epilepsy (Annegers et al, 1988;Pomeroy et al, 1990;Chang et al, 2004). Seizures during acute phase of meningitis are associated with an increased risk for developing late unprovoked seizures.…”

Section: Risk Factors For Late Unprovoked Seizuresmentioning

confidence: 99%

“…In the Olmsted County, Minnesota, the 20-year risk of developing an unprovoked seizure/epilepsy was 13% for those with bacterial meningitis and early seizures, and 2.4% for those with bacterial meningitis without early seizures (Annegers et al, 1988). Factors associated with seizures during acute phase of illness include disturbed consciousness on admission, abnormal neuroimaging findings, and low glucose and high protein concentration in the cerebrospinal fluid (Chang et al, 2004). In a hospital-based study, children with persistent neurological abnormalities other than sensorineural hearing loss demonstrated an increased risk of having at least one late unprovoked seizure (Pomeroy et al, 1990).…”

Section: Risk Factors For Late Unprovoked Seizuresmentioning

confidence: 99%

“…The majority of unprovoked seizures following bacterial meningitis occur within 5 years of the acute illness (de Graaf, 1974;Bergamini et al, 1977;Sell et al, 1977;Rantakallio et al, 1986;Annegers et al, 1988;Pomeroy et al, 1990;Chang et al, 2004). Unprovoked seizures following bacterial meningitis tend to be recurrent (Rosman et al, 1985;Annegers et al, 1988;Pomeroy et al, 1990).…”

Section: Seizure Semiology Course and Prognosismentioning

confidence: 99%

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Bacterial meningitis and epilepsy

Murthy¹,

Prabhakar

2008

Epilepsia

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SUMMARYThe high incidence and prevalence of epilepsy in developing countries has partly been attributed to an increased frequency of central nervous system (CNS) infections. Of the CNS infections, bacterial meningitis is endemic in many countries and several epidemics have also been reported in these regions. Unprovoked seizures and epilepsy (recurrent unprovoked seizures) can be long-term sequelae of bacterial meningitis. The probability of developing an unprovoked seizure or epilepsy varies according to the etiologic agent responsible for meningitis and this probability appears to be higher for Streptococcus pneumoniae. The risk factors for late unprovoked seizures/epilepsy include early seizures during the acute phase of meningitis and persistent neurological deficits other than sensorineural hearing loss. The majority of unprovoked seizures occur within 5 years of the meningitis episode and tend to be recurrent. The burden of epilepsy associated with bacterial meningitis depends upon the incidence of the latter and hence is to some extent preventable. Implementing vaccination programs against the three most important meningeal pathogens can reduce the incidence of bacterial meningitis. In developed countries, a decline in the incidence of bacterial meningitis has been accomplished with the implementation of vaccination programs.

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Clinical Predictors for Hearing Loss in Children With Bacterial Meningitis

Kutz¹,

Simon²,

Chennupati³

et al. 2006

Arch Otolaryngol Head Neck Surg

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To identify clinical risk factors that predict a higher incidence of hearing loss in children with bacterial meningitis, to determine the overall incidence of hearing loss in a large group of children proven by culture findings to have bacterial meningitis, and to compare clinical characteristics among patients with Streptococcus pneumoniae meningitis and Neisseria meningitidis meningitis. Design: Retrospective review Setting: Tertiary pediatric hospital. Patients: A total of 171 children identified with bacterial meningitis who met inclusion criteria over a consecutive 10-year period. Main Outcome Measure: Presence of sensorineural hearing loss. Results: Of 134 patients who underwent audiologic testing during their initial hospitalization, 41 (30.6%) were found to have at least a unilateral mild sensorineural hearing loss. The incidence of hearing loss was greater in patients with S pneumoniae meningitis than in patients with N meningitidis meningitis (35.9% and 23.9%, respectively). Length of hospitalization, development of seizures, elevated cerebrospinal fluid protein, and decreased cerebrospinal fluid glucose were significant predictors for hearing loss in children with bacterial meningitis. These factors were not found to be as strong a predictor for hearing loss in patients with N meningitidis meningitis. Stability of hearing was demonstrated with limited follow-up audiometry. Conclusions: Sensorineural hearing loss is a common sequela in children with bacterial meningitis. Identification of hearing loss in children with bacterial meningitis and early rehabilitation will lessen the long-term educational and social difficulties these children may experience.

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Seizures complicating infantile and childhood bacterial meningitis

Cited by 37 publications

References 20 publications

Predictors of long term neurological outcome in bacterial meningitis

Predictors of long term neurological outcome in bacterial meningitis

Bacterial meningitis and epilepsy

Clinical Predictors for Hearing Loss in Children With Bacterial Meningitis

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