Seizures caused by nontraumatic parenchymal brain hemorrhages

Weisberg, Leon A.; Shamsnia, Morteza; Elliott, Debra

doi:10.1212/wnl.41.8.1197

Cited by 55 publications

(34 citation statements)

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“…Thus, there was continued uncertainty in assessing the incidence of chronic epilepsy/unprovoked seizures after spontaneous ICH in nonselected patients Several authors have reported variables related to seizures after spontaneous ICH. 4,3,9,14,15,19,22 Cerebral hemorrhages giving rise to seizures were predominantly cortical in location, 3,10,16,19,22 although two-thirds of seizures arose from deep cerebral hemorrhages in our study (in 12 patients), a figure lower than previous studies. 3,19,22 Our study demonstrated that presence of cortical hemorrhage was predictive of seizures.…”

Section: Discussioncontrasting

confidence: 81%

“…4,3,9,14,15,19,22 Cerebral hemorrhages giving rise to seizures were predominantly cortical in location, 3,10,16,19,22 although two-thirds of seizures arose from deep cerebral hemorrhages in our study (in 12 patients), a figure lower than previous studies. 3,19,22 Our study demonstrated that presence of cortical hemorrhage was predictive of seizures. The authors of several studies 4,22 have noted that neither the amount of blood present in brain parenchyma (such as lesion size) nor in the cisternal and ventricular spaces seemed to affect the occurrence of seizures.…”

Section: Discussioncontrasting

confidence: 81%

“…3,19,22 Our study demonstrated that presence of cortical hemorrhage was predictive of seizures. The authors of several studies 4,22 have noted that neither the amount of blood present in brain parenchyma (such as lesion size) nor in the cisternal and ventricular spaces seemed to affect the occurrence of seizures. However, our results demonstrated that higher mean ICH volumes at presentation were predictive of seizure, and an increase of 1 mm 3 in ICH volume will increase the seizure rate by 2.7%.…”

Section: Discussionmentioning

confidence: 52%

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Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Yang¹,

Lin

Chang

et al. 2009

JNS

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Object. Seizures are an important neurological complication of spontaneous intracerebral hemorrhage (ICH).A better understanding of the risk factors of seizures following ICH is needed to predict which patients will require treatment.Methods. Two hundred and forty-three adult patients were enrolled in this 1-year retrospective study. Multiple logistic regression was used to evaluate the relationship between baseline clinical factors and the presence or absence of seizure during the study period.Results. Seizures occurred in 20 patients with ICH, including acute symptomatic seizures in 9 and unprovoked seizures in 11. None progressed to status epilepticus during hospitalization. After a minimum 3-year follow-up period, the mean Glasgow Outcome Scale score was 3.8 ± 1.1 for patients who had had seizures and 3.5 ± 1.3 for those who had not. The multiple logistic regression model demonstrated that the mean ICH volume was independently as sociated with seizures, and any increase of 1 mm 3 in ICH volume increased the seizure rate by 2.7%. Conclusions. Higher mean ICH volumes at presentation were predictive of seizure, and the presence of late seizures was predictive of developing epilepsy. Most seizures occurred within 2 years of spontaneous ICH over a minimum of 3 years of follow-up. (DOI: 10.3171/2009.2.JNS081622) KeY WorDs • outcome • risk factor • seizure • spontaneous intracerebral hemorrhage 87Abbreviations used in this paper: AED = antiepileptic drug; GCS = Glasgow Coma Scale; GOS = Glasgow Outcome Scale; ICH = intracerebral hemorrhage; ROI = region of interest.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 52%

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Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Yang¹,

Lin

Chang

et al. 2009

JNS

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“…2,7 The incidence of SE after stroke either is low or is not cited at all in some reports. [1][2][3][4][5][17][18][19][20] Three studies reported the rate of SE as 19%, 17%, and 14%. 7,21,22 We found that SE occurred in 9% of all patients admitted for a PFS to our Neurology Department.…”

Section: Discussionmentioning

confidence: 99%

Status Epilepticus After Stroke

Velioğlu

Özmenoğlu

Boz

et al. 2001

Stroke

121

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Background and Purpose-The main objective of our study was to determine the risk and predictive factors of status epilepticus (SE) after stroke. Methods-From 1988 to 2000, 1174 patients were admitted to the Department of Neurology at the Karadeniz Technical University Farabi Hospital with first-time strokes. Of these, 180 patients had poststroke first-time seizures (PFSs). We followed these 180 PFS patients for an average of 3.7 years or until death to determine the occurrence rate of SE. By comparing these data with those of PFS patients without SE, we investigated whether there were significant differences. Results-A total of 17 of the 180 PFS patients (9%) had SE. There was no relationship between the occurrence of SE and stroke risk factors, stroke type (ischemic or hemorrhagic stroke), stroke topography and cause, cortical involvement, size of lesion, seizure type, or electroencephalographic findings. SE occurred more frequently among patients with a higher disability rating (Rankin scale Ͼ3; odds ratio, 4.36). Recurrent SE was identified in 5 of 17 patients with SE. In all 5 of these patients, the first episode of SE occurred within the first 7 days after stroke (early-onset SE). Statistical analysis demonstrated that early-onset SE was associated with a higher risk for SE recurrence (Pϭ0.003) and a higher mortality rate (Pϭ0.04). Conclusions-SE was not associated with a higher mortality rate but with higher functional disability. We also found that early-onset SE (within the first 7 days after stroke) was associated with a higher risk for SE recurrence and a higher mortality rate than late-onset SE (after 7 days after stroke).

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“…2 A brief course of anticonvulsant therapy after lobar ICH may reduce the risk of early seizures. 3 The published incidence of seizures after ICH varies widely from Ͻ10%, 4,5 to 10% to 20%, 6 to Ͼ20%. 7 Many seizures are detected only with electroencephalographic monitoring.…”

mentioning

confidence: 99%

Anticonvulsant Use and Outcomes After Intracerebral Hemorrhage

Naidech

Garg

Liebling

et al. 2009

Stroke

184

123

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Background and Purpose-There are few data on the effectiveness and side effects of antiepileptic drug therapy after intracerebral hemorrhage. We tested the hypothesis that antiepileptic drug use is associated with more complications and worse outcome after intracerebral hemorrhage. Methods-We prospectively enrolled 98 patients with intracerebral hemorrhage and recorded antiepileptic drug use as either prophylactic or therapeutic along with clinical characteristics. Antiepileptic drug administration and free phenytoin serum levels were retrieved from the electronic medical records. Patients with depressed mental status underwent continuous electroencephalographic monitoring. Outcomes were measured with the National Institutes of Health Stroke Scale and modified Rankin Scale at 14 days or discharge and the modified Rankin Scale at 28 days and 3 months. We constructed logistic regression models for poor outcome at 3 months with a forward conditional model. Results-Seven

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Seizures caused by nontraumatic parenchymal brain hemorrhages

Cited by 55 publications

References 0 publications

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Predictors and outcome of seizures after spontaneous intracerebral hemorrhage

Status Epilepticus After Stroke

Anticonvulsant Use and Outcomes After Intracerebral Hemorrhage

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