Seizures associated with memantine use

Peltz, Gayle; Pacific, Domenica M.; Noviasky, John; Shatla, Ahmed; Mehalic, Theodore

doi:10.1093/ajhp/62.4.0420

Cited by 5 publications

(8 citation statements)

References 4 publications

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“…Documented seizures induced by donepezil in an Alzheimer's disease patient have been reported [13]. The other commonly used agent, memantine, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist, and has also been shown to induce seizures [14].…”

Section: Discussionmentioning

confidence: 99%

Seizures in an Alzheimer’s Disease Patient as a Complication of Colonoscopy Premedication with Meperidine

2007

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We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease. The active metabolite of meperidine, normeperidine, is postulated to be the precipitating cause of the seizures, although a cholinesterase inhibitor and an N-methyl-D: -aspartate receptor antagonist, both routinely used for treatment of Alzheimer's disease, may have contributed by reducing the seizure threshold. The neuronal changes which occur in Alzheimer's disease can themselves also predispose to seizures. We recommend avoidance of meperidine for all flexible endoscopic procedures on patients with Alzheimer's disease and in any patient with a condition that predisposes to seizures, and suggest the use of alternative opioids.

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Section: Discussionmentioning

confidence: 99%

Seizures in an Alzheimer’s Disease Patient as a Complication of Colonoscopy Premedication with Meperidine

2007

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“…10,11 Even though it is believed that memantine avoids adverse effects of some other NMDA-receptor antagonists, both psychosis and seizures were described during memantine treatment. 5,12 Prolonged treatment with memantine is reported to induce changes in GABA(A) receptors in rats that might contribute to both therapeutic and toxic effects, 13 and in a study looking at potentiation of neurotoxicity of memantine by combining them with cholinesterase inhibitors it was postulated that by blocking NMDA receptors on different cell types, memantine might promote seizure activity but also alter its propagation, making classic motor manifestations of possible seizure activity less evident, 14 which would be consistent with the expression of the described episodes.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Care is advised in patients with a history of seizures; new-onset generalized tonic-clonic seizures during treatment with memantine have been reported. 5 Memantine was also implicated in cardiac adverse reactions, specifically bradycardia, although with an unclear underlying mechanism. 6 We present 2 cases of unexplained loss of consciousness after long-term memantine treatment in patients with AD.…”

Section: Introductionmentioning

confidence: 99%

Two Cases of Loss of Consciousness After Long-Term Memantine Treatment

Savić¹,

Mímica²

2013

Journal of the American Medical Directors Association

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“…While one study reports that memantine can lower seizure threshold [59], another study reports statistically significant benefits of using memantine to improve cognition in epileptic patients with a good safety profile and no noted adverse effects [60]. Out of all the adverse drug reactions noted on donepezil and rivastigmine, 8.4% and 6.4% respectively were accounted for by convulsions [61].…”

Section: Consideration Of Ad Drugs In Seizuresmentioning

confidence: 99%

“…Clinical judgment should be exercised for individual patients. No Empirical treatment with AED is indicated in patients without clinical or electrographic signs of network hyperexcitability but can be started if concerned that it is causing cognitive impairment [59]. In symptomatic AD patients, the risk of recurrence after the first unprovoked seizure stands at 70% and it is recommended to treat them indefinitely [67].…”

Section: Consideration Of Ad Drugs In Seizuresmentioning

confidence: 99%

The Association Between Alzheimer's Disease and Epilepsy: A Narrative Review

Purushotham¹,

Tashrifwala²,

Jena³

et al. 2022

Cureus

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Several studies have established the two-way relationship between the sporadic and familial forms of Alzheimer's disease (AD) and epilepsy. However, a more robust connection exists between epilepsy and early onset familial AD (EOFAD). Still, the mechanisms underlying the same are not yet fully understood. Aging is also known to be associated with both AD and seizures. Seizures of any type can occur at any stage of AD and are six to 10 times more likely in patients with AD than in controls of a similar age group. Seizures can quicken cognitive decline and increase mortality, amplifying the medical and economic burden. It is, therefore, clinically essential to recognize and treat seizures early in these patients. However, diagnosis of seizures in AD is complicated by the difficulty in identifying non-motor focal seizures in patients with cognitive decline, problems with obtaining histories, low sensitivity of standard scalp electroencephalogram (EEG) methods, nonspecific cerebrospinal fluid (CSF) and radiological findings. This article has reviewed and summarised the existing literature on the association between AD and epilepsy pertaining to epidemiology, pathophysiological links, risk factors, modalities for diagnosis, and treatment strategies.

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Seizures associated with memantine use

Cited by 5 publications

References 4 publications

Seizures in an Alzheimer’s Disease Patient as a Complication of Colonoscopy Premedication with Meperidine

Seizures in an Alzheimer’s Disease Patient as a Complication of Colonoscopy Premedication with Meperidine

Two Cases of Loss of Consciousness After Long-Term Memantine Treatment

The Association Between Alzheimer's Disease and Epilepsy: A Narrative Review

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