Seizures associated with fever: clinical data as predictors for normal biochemical blood levels

Stuijvenberg, Margriet van; Gijssel, E. N. van; Steyerberg, Ewout W.; Moons, Karel G.M.; Derksen‐Lubsen, Gerarda; Moll, Henriëtte A.

doi:10.1007/s004310050886

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…20,28 Van Stuijvenberg et al in a study done in children with seizures associated with fever found that abnormal biochemical blood test results are rare and outside the morbidity range and in children with a low probability of a normal result as calculated by the score chart, the test may be indicated. 29 On the other hand, Kenney et al have shown that routine measurements of biochemical tests are not necessary in febrile convulsion. 30 The limitations of this study are that the sample size was small compared to the general population and the patients were not followed up later with the repeat blood levels of magnesium.…”

Section: Blood Calciummentioning

confidence: 99%

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Addlur

Khandelwal

Mangajjera

et al. 2021

Int J Contemp Pediatr

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Background: Febrile convulsions is one of the most common type of seizures seen in children. It has been suggested that low serum magnesium (Mg) has occasionally been associated with epilepsy. A positive correlation of the hypomagnesemia with the severity of epilepsy was also found. The present study aimed to estimate the levels of serum magnesium in children with febrile convulsions and to compare serum magnesium levels with normal children.Methods: Fifty patients who were eligible after screening for inclusion and exclusion criteria were included in the study group after a signed written informed consent and 50 controls were also taken. A detailed history, clinical examination and these investigations were done – complete blood count (CBC) (Hb, DC and ESR), serum calcium, serum magnesium, serum electrolytes, random blood sugar and cerebrospinal fluid (CSF) analysis.Results: The serum magnesium level was normal in 45 patients (90%) with febrile convulsions, low levels in 4 cases (8%) and high levels seen in 1 case (2%). Serum magnesium levels were normal in all 50 controls. In this study, the serum magnesium levels has got no correlation in patients with febrile convulsion. So, routine magnesium supplementation need not be prescribed in normal subjects to prevent febrile convulsions.Conclusions: Routine measurement of serum levels of Mg, glucose and calcium are warranted in subject with febrile convulsions. However, large prospective studies are further required in future to establish the correlation of serum Mg and febrile convulsions so that a standard guidelines can be set up which could be followed universally.

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Section: Blood Calciummentioning

confidence: 99%

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Addlur

Khandelwal

Mangajjera

et al. 2021

Int J Contemp Pediatr

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“…The decreasing rate of bacterial meningitis in FC is welcome, but the main question remains: can a FC be the sole manifestation of this serious infection in the young child, without any other unusual symptom or sign to suggest serious bacterial illness or abnormal neurologic status? A review of 15 published reports of meningitis with FC between 1977 and 1999 was carried out [6,9,11,13,15,17,[21][22][23][24][25][26][27][28][29][30]. From a total of 4102 children with FC, 33 were found to have bacterial meningitis of which 26 already had clinical signs of meningitis.…”

Section: Meningitis Presenting As Convulsion With Fever -The Evidencementioning

confidence: 99%

Febrile convulsions: When is a lumbar puncture indicated?

Narchi

2015

J Pediatr Neurol

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Febrile convulsions are common. Although they have an excellent long-term prognosis regarding the risk of epilepsy later in life, the main challenge posed upon presentation is whether a lumbar puncture is indicated in very young children. Despite several authoritative guidelines over the past 15 years, there is still no consensus, with seemingly contradictory recommendations. In addition, the practice varies considerably among health care workers with a trend toward fewer lumbar punctures being performed. The epidemiology of bacterial meningitis has also changed considerably over the past two decades, both in its overall prevalence and also in the bacterial etiology. We believe that all these reasons provide the opportunity to critically review the available evidence for the likelihood of bacterial meningitis presenting as an isolated febrile convulsion. We also wish to estimate its true prevalence, grading the level of that evidence for this practice and also identify subgroups where meningitis is more likely. Finally, since most guidelines are based on the assumption that normal cerebral spinal fluid results would confidently exclude bacterial meningitis, we address the validity of this assumption. Following the critical review, modified guidelines are suggested, with support of grading of the level of evidence behind them and of the strength of those recommendations.

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