Seizure With an Unusual Clinical Semiology Mimicking Psychosis: A Case Report

Sethi, Nitin K.; Emery, Eleanor

doi:10.1176/appi.neuropsych.12060146

Cited by 2 publications

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References 2 publications

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“…Epilepsy and schizophrenia are two common brain‐involved disorders. Patients with epilepsy are at increased risk of developing psychosis compared with the general population (Chen et al, ; Tellez‐Zenteno, Patten, Jette, Williams, & Wiebe, ; Torta & Keller, ; Vuilleumier & Jallon, ) and some forms of seizures may mimic the symptoms of psychosis (Sethi & Emery, ; Tucker, ); therefore better understanding of epilepsy might also provide insights on the understanding of mental illness like schizophrenia, and vice versa. One example is from brain image studies, which revealed hippocampus volume is probably related to both epilepsy and schizophrenia (Jack, ; Nelson, Saykin, Flashman, & Riordan, ).…”

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confidence: 99%

Genetic overlap between epilepsy and schizophrenia: Evidence from cross phenotype analysis in Hong Kong Chinese population

Gui

Sham

et al. 2017

American J of Med Genetics Pt B

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Epilepsy and schizophrenia are common and typical neurological or mental illness respectively, and sometimes they comorbid in the same patients, however the underlying genetic relationship between the two brain diseases is still not fully understood. To investigate the possible genetic contribution to their comorbidity, we performed polygenic risk score (PRS) analyses and genetic correlation estimation so as to identify the overall genetic overlap between the two diseases. The global schizophrenia PRS is strongly associated with schizophrenia phenotype in Hong Kong population (odds ratio = 1.7, p = 2.26E-16), and focal epilepsy PRS is moderately associated with epilepsy phenotype in Hong Kong population (odds ratio = 1.14, p = 0.013). However the disease-specific PRS can only predict its own well-matched phenotype but not the other ones (p > 0.05). This pattern is further supported by non-significant pairwise genetic correlation and insufficient statistical power for PRS association from the cross-phenotype analyses. Our study reveals there's limited shared genetic aetiology between schizophrenia and epilepsy, and thus supports a model of shared environmental factors to explain the comorbidity between the two phenotypes.

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Section: Introductionmentioning

confidence: 99%

Genetic overlap between epilepsy and schizophrenia: Evidence from cross phenotype analysis in Hong Kong Chinese population

Gui

Sham

et al. 2017

American J of Med Genetics Pt B

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“…The second is in the occasional TLE patient in whom bitemporal interictal and ictal epileptiform features are identified. We recently reported a patient in whom the postictal psychotic state was characterized by violent and self-injurious behavior À pulling off the EEG electrodes, biting and ripping the phone cord, yanking the intravenous line and running out of her room [2]. Ictal EEG showed seizure onset and progression in the left temporal lobe.…”

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Postictal psychosis in temporal lobe epilepsy

Sethi

Milrad

Katus

et al. 2013

Euro J of Neurology

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Sir,We read with interest the Hilger et al.[1] study on postictal psychosis (PP) in patients with temporal lobe epilepsy (TLE). In our experience we have encountered PP in two distinct settings. The first is in patients admitted to the epilepsy monitoring unit for seizure characterization and localization and who suffer a flurry of secondary generalized seizures after anticonvulsant taper. The PP state in these patients is characterized by a rather dramatic change in behavior and personality although not necessarily violence towards self or others. The second is in the occasional TLE patient in whom bitemporal interictal and ictal epileptiform features are identified. We recently reported a patient in whom the postictal psychotic state was characterized by violent and self-injurious behavior À pulling off the EEG electrodes, biting and ripping the phone cord, yanking the intravenous line and running out of her room [2]. Ictal EEG showed seizure onset and progression in the left temporal lobe. About 15 s later offset of ictal discharge is noted on the left and onset and evolution occurs in the right temporal lobe (Fig. 1). Disclosure of conflict of interestThe authors declare no financial or other conflict of interest. References1. Hilger E, Zimprich F, Jung R, Pataraia E, Baumgartner C, Bonelli S. Postictal psychosis in temporal lobe epilepsy: a caseÀcontrol study. Eur J Neurol 2013; 20: 955-961. 2. Sethi NK, Emery E. Seizure with an unusual clinical semiology mimicking psychosis: a case report. J Neuropsychiatry Clin Neurosci 2013; 25: E66-E67. Figure 1 Ictal EEG showed seizure onset and progression in the left temporal lobe. About 15 s later offset of ictal discharge is noted on the left and onset and evolution occurs in the right temporal lobe.

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Seizure With an Unusual Clinical Semiology Mimicking Psychosis: A Case Report

Cited by 2 publications

References 2 publications

Genetic overlap between epilepsy and schizophrenia: Evidence from cross phenotype analysis in Hong Kong Chinese population

Genetic overlap between epilepsy and schizophrenia: Evidence from cross phenotype analysis in Hong Kong Chinese population

Postictal psychosis in temporal lobe epilepsy

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