Seizure‐modifying potential of histamine H<sub>1</sub> antagonists: A clinical observation

Miyata, Ippei; Saegusa, Hirokazu; Sakurai, Michiro

doi:10.1111/j.1442-200x.2011.03328.x

Cited by 39 publications

(27 citation statements)

References 6 publications

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“…Establishing a diagnosis is often of value even when a clear change in treatment is not indicated by the diagnosis. For example, close and ongoing observation for seizures is now indicated for patient 5 ( TCF4 ), and avoidance of medications that may trigger seizures, such as antihistamines 52. The family can be informed that the disorder is due to a de novo variant, and in the absence of parental mosaicism, other family members are not at risk, and with future pregnancies the recurrence risk for the parents is low.…”

Section: Discussionmentioning

confidence: 99%

Clinical application of exome sequencing in undiagnosed genetic conditions

et al. 2012

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BackgroundThere is considerable interest in the use of next-generation sequencing to help diagnose unidentified genetic conditions, but it is difficult to predict the success rate in a clinical setting that includes patients with a broad range of phenotypic presentations.MethodsThe authors present a pilot programme of whole-exome sequencing on 12 patients with unexplained and apparent genetic conditions, along with their unaffected parents. Unlike many previous studies, the authors did not seek patients with similar phenotypes, but rather enrolled any undiagnosed proband with an apparent genetic condition when predetermined criteria were met.ResultsThis undertaking resulted in a likely genetic diagnosis in 6 of the 12 probands, including the identification of apparently causal mutations in four genes known to cause Mendelian disease (TCF4, EFTUD2, SCN2A and SMAD4) and one gene related to known Mendelian disease genes (NGLY1). Of particular interest is that at the time of this study, EFTUD2 was not yet known as a Mendelian disease gene but was nominated as a likely cause based on the observation of de novo mutations in two unrelated probands. In a seventh case with multiple disparate clinical features, the authors were able to identify homozygous mutations in EFEMP1 as a likely cause for macular degeneration (though likely not for other features).ConclusionsThis study provides evidence that next-generation sequencing can have high success rates in a clinical setting, but also highlights key challenges. It further suggests that the presentation of known Mendelian conditions may be considerably broader than currently recognised.

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Section: Discussionmentioning

confidence: 99%

Clinical application of exome sequencing in undiagnosed genetic conditions

et al. 2012

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“…Clinically, children with febrile seizures had lower CSF histamine than those with fever but no convulsions, suggesting an anti-seizure effect of histamine [88,149]. Moreover, it has been found that H1R antagonists increased the incidence of seizures in children [150]. Furthermore, abnormal levels of H1Rs around the focus of epileptic injury in complex partial seizures were noticed in human positron emission tomography studies [151].…”

Section: Epilepsymentioning

confidence: 95%

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Sadek

Saad

Sadeq

et al. 2016

Behavioural Brain Research

129

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“…Based on these findings, the suggestion was made that brain histaminergic system may be involved in inhibiting seizures associated with febrile illnesses in childhood (Kiviranta et al, 1995). The clinical data amply documented proconvulsant effects of H 1 R antagonists administered in clinically relevant doses (Churchill and Gammon, 1949; Yokoyama et al, 1993; Takano et al, 2010; Miyata et al, 2011; Zolaly, 2012). Therefore, centrally acting H 1 R antagonists which may increase seizure susceptibility in patients with febrile seizures are neither recommended to these patients nor to PWE.…”

Section: Monoamines In Epilepsy: Preclinical and Clinical Evidencementioning

confidence: 99%

Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

et al. 2016

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A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another. In this review, we will focus on the role of serotonin, dopamine, noradrenaline, histamine, and melatonin in epilepsy. Recent experimental, clinical, and genetic evidence will be reviewed in consideration of the mutual relationship of monoamines with the other putative neurotransmitters. The complexity of epileptic pathogenesis may explain why the currently available drugs, developed according to the classic drug discovery paradigm of “one-molecule-one-target,” have turned out to be effective only in a percentage of PWE. Although, no antiepileptic drugs currently target specifically monoaminergic systems, multi-target directed ligands acting on different monoaminergic proteins, present on both neurons and glia cells, may represent a new approach in the management of seizures, and their generation as well as comorbid neuropsychiatric disorders.

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Seizure‐modifying potential of histamine H₁ antagonists: A clinical observation

Abstract: Clinical doses of histamine H(1) antagonists have the potential to adversely modify seizures in children.

Cited by 39 publications

References 6 publications

Clinical application of exome sequencing in undiagnosed genetic conditions

Clinical application of exome sequencing in undiagnosed genetic conditions

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

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Seizure‐modifying potential of histamine H1 antagonists: A clinical observation

Abstract: Clinical doses of histamine H(1) antagonists have the potential to adversely modify seizures in children.

Cited by 39 publications

References 6 publications

Clinical application of exome sequencing in undiagnosed genetic conditions

Clinical application of exome sequencing in undiagnosed genetic conditions

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

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Seizure‐modifying potential of histamine H₁ antagonists: A clinical observation