Seizure in a Nonpredisposed Individual Induced by Single-Pulse Transcranial Magnetic Stimulation

Kratz, Oliver; Studer, Petra; Barth, Wolf; Wangler, Susanne; Hoegl, Thomas; Heinrich, Hartmut; Moll, Gunther H.

doi:10.1097/yct.0b013e3181d2ef85

Cited by 24 publications

(9 citation statements)

References 20 publications

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“…Magnetic stimulation is not entirely benign, in that it can inadvertently instigate seizures, even with single pulses 102. A systematic literature review94 found 16 cases of seizures with TMS.…”

Section: Neurostimulationmentioning

confidence: 99%

Therapeutic devices for epilepsy

Fisher

2012

Annals of Neurology

111

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Therapeutic devices provide new options for treating drug-resistant epilepsy. These devices act by a variety of mechanisms to modulate neuronal activity. Only vagus nerve stimulation, which continues to develop new technology, is approved for use in the United States. Deep brain stimulation (DBS) of anterior thalamus for partial epilepsy recently was approved in Europe and several other countries. Responsive neurostimulation, which delivers stimuli to one or two seizure foci in response to a detected seizure, recently completed a successful multicenter trial. Several other trials of brain stimulation are in planning or underway. Transcutaneous magnetic stimulation (TMS) may provide a noninvasive method to stimulate cortex. Controlled studies of TMS split on efficacy, and may depend on whether a seizure focus is near a possible region for stimulation. Seizure detection devices in the form of “shake” detectors via portable accelerometers can provide notification of an ongoing tonic-clonic seizure, or peace of mind in the absence of notification. Prediction of seizures from various aspects of EEG is in early stages. Prediction appears to be possible in a subpopulation of people with refractory seizures and a clinical trial of an implantable prediction device is underway. Cooling of neocortex or hippocampus reversibly can attenuate epileptiform EEG activity and seizures, but engineering problems remain in its implementation. Optogenetics is a new technique that can control excitability of specific populations of neurons with light. Inhibition of epileptiform activity has been demonstrated in hippocampal slices, but use in humans will require more work. In general, devices provide useful palliation for otherwise uncontrollable seizures, but with a different risk profile than with most drugs. Optimizing the place of devices in therapy for epilepsy will require further development and clinical experience.

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Section: Neurostimulationmentioning

confidence: 99%

Therapeutic devices for epilepsy

Fisher

2012

Annals of Neurology

111

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“…Electroencephalogram (EEG), electrocardiogram examinations and a medical interview were performed to exclude participants with cardiovascular diseases, low seizure threshold or predisposition for syncope [44], [45].…”

Section: Methodsmentioning

confidence: 99%

Time Course Analysis of Motor Excitability in a Response Inhibition Task According to the Level of Hyperactivity and Impulsivity in Children with ADHD

et al. 2012

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Short interval intracortical inhibition (SICI) of motor cortex, measured by transcranial magnetic stimulation (TMS) in a passive (resting) condition, has been suggested as a neurophysiological marker of hyperactivity in attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to determine motor excitability in a go/nogo task at stages of response preparation, activation and suppression in children with ADHD, depending on the level of hyperactivity and impulsivity. Motor evoked potentials were recorded in 29 typically developing children and 43 children with ADHD (subdivided in two groups with higher and lower levels of hyperactivity/impulsivity; H/I-high and H/I-low). In the H/I-high group, SICI was markedly reduced in the resting condition and during response preparation. Though these children were able to increase SICI when inhibiting a response, SICI was still reduced compared to typically developing children. Interestingly, SICI at rest and during response activation were comparable, which may be associated with their hypermotoric behaviour. In the H/I-low group, response activation was accompanied by a pronounced decrease of SICI, indicating reduced motor control in the context of a fast motor response. In summary, different excitability patterns were obtained for the three groups allowing a better understanding of dysfunctional response activation and inhibition processes within the motor cortex in children with ADHD.

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“…The direct cortical stimulation achieved by rTMS is unique in that it does not result in widespread systemic effects, thereby lessening side effects and increasing tolerability. Although rTMS has been found to be relatively safe, it is possible that rTMS can induce hypomanic/manic symptoms and seizures [38,55]. However, the incidence of these adverse effects is exceedingly rare and can be avoided by carefully screening patients for known risk factors, in addition to strictly adhering to recommended rTMS stimulation parameters [38].…”

Section: Associated Risks With Tms and Methods To Minimize Risksmentioning

confidence: 99%

Clinical applications of electroconvulsive therapy and transcranial magnetic stimulation for the treatment of major depressive disorder: a critical review

Baker

Treviño

McClintock³

et al. 2012

Neuropsychiatry

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Depression is a common and debilitating psychiatric disorder that is often unable to be effectively treated with pharmacotherapeutic agents alone. Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are among several somatic therapies available for the treatment of major depression. The purpose of this article is to synthesize current information on ECT and repetitive TMS as treatments for pharmacotherapy-resistant major depression regarding its use in neuropsychiatric clinical practice. The current psychiatric literature indicates that both ECT and TMS are effective antidepressant treatments. ECT is a safe and highly effective treatment for depression. The literature also illustrates that TMS has a favorable side-effect profile, excellent tolerability and modest efficacy. To date, additional research is being conducted to further enhance ECT and TMS treatment, and to further define their role in treatment algorithms.

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Seizure in a Nonpredisposed Individual Induced by Single-Pulse Transcranial Magnetic Stimulation

Cited by 24 publications

References 20 publications

Therapeutic devices for epilepsy

Therapeutic devices for epilepsy

Time Course Analysis of Motor Excitability in a Response Inhibition Task According to the Level of Hyperactivity and Impulsivity in Children with ADHD

Clinical applications of electroconvulsive therapy and transcranial magnetic stimulation for the treatment of major depressive disorder: a critical review

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