Seizure Control With Clomiphene Therapy

Hormonal Effects on Epilepsy in Women

“…It exerts a dose-dependent antiepileptic effect in rats (7). Remarkable reductions in seizure frequency have been reported with clomiphene in a number of isolated cases in both men and women (79,80). In one series of 12 women who had complex partial seizures and menstrual disorders (polycystic ovarian syndrome or inadequate luteal phase cycles) and who were given clomiphene, 10 improved, many dramatically, with an 87% average decline in seizure frequency (81).…”

Hormonal Effects on Epilepsy in Women

“…It exerts a dose-dependent antiepileptic effect in rats (7). Remarkable reductions in seizure frequency have been reported with clomiphene in a number of isolated cases in both men and women (79,80). In one series of 12 women who had complex partial seizures and menstrual disorders (polycystic ovarian syndrome or inadequate luteal phase cycles) and who were given clomiphene, 10 improved, many dramatically, with an 87% average decline in seizure frequency (81).…”

Reproductive Endocrine Considerations and Hormonal Therapy for Men with Epilepsy

“…Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982). It offered no benefit, however, for a man who had complex partial seizures and hypergonadotropic hypogonadism, i.e., gonadal failure (Herzog, 1988). Total and free AED levels were not affected.…”

“…Clomiphene dramatically benefitted sexual interest, potency, and seizure control in one case report of a man with complex partial seizures and hypogonadotropic hypogonadism (Herzog, 1988). Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982).…”

Neurogenic erectile dysfunction

“…The association of temporal lobe lesions and epileptic seizures with ED has been reported [26][27][28]. Herzog et al…”

“…have suggested that epileptic discharges in the medial temporal lobe may disrupt hypothalamic regulation of pituitary secretion and result in increased prolactin and decreased testosterone levels [27]. Epilepsy, while neurogenic in origin, can therefore result in endocrinologic ED.…”

Hormonal Effects on Epilepsy in Women

“…It exerts a dose-dependent antiepileptic effect in rats (7). Remarkable reductions in seizure frequency have been reported with clomiphene in a number of isolated cases in both men and women (79,80). In one series of 12 women who had complex partial seizures and menstrual disorders (polycystic ovarian syndrome or inadequate luteal phase cycles) and who were given clomiphene, 10 improved, many dramatically, with an 87% average decline in seizure frequency (81).…”

Reproductive Endocrine Considerations and Hormonal Therapy for Men with Epilepsy

“…Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982). It offered no benefit, however, for a man who had complex partial seizures and hypergonadotropic hypogonadism, i.e., gonadal failure (Herzog, 1988). Total and free AED levels were not affected.…”

“…Clomiphene dramatically benefitted sexual interest, potency, and seizure control in one case report of a man with complex partial seizures and hypogonadotropic hypogonadism (Herzog, 1988). Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982).…”

Neurogenic erectile dysfunction

“…The association of temporal lobe lesions and epileptic seizures with ED has been reported [26][27][28]. Herzog et al…”

“…have suggested that epileptic discharges in the medial temporal lobe may disrupt hypothalamic regulation of pituitary secretion and result in increased prolactin and decreased testosterone levels [27]. Epilepsy, while neurogenic in origin, can therefore result in endocrinologic ED.…”

Hormonal Effects on Epilepsy in Women

“…It exerts a dose-dependent antiepileptic effect in rats (7). Remarkable reductions in seizure frequency have been reported with clomiphene in a number of isolated cases in both men and women (79,80). In one series of 12 women who had complex partial seizures and menstrual disorders (polycystic ovarian syndrome or inadequate luteal phase cycles) and who were given clomiphene, 10 improved, many dramatically, with an 87% average decline in seizure frequency (81).…”

Reproductive Endocrine Considerations and Hormonal Therapy for Men with Epilepsy

“…Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982). It offered no benefit, however, for a man who had complex partial seizures and hypergonadotropic hypogonadism, i.e., gonadal failure (Herzog, 1988). Total and free AED levels were not affected.…”

“…Clomiphene dramatically benefitted sexual interest, potency, and seizure control in one case report of a man with complex partial seizures and hypogonadotropic hypogonadism (Herzog, 1988). Seizures were eliminated during clomiphene use in another case with epilepsy and oligospermia (Check et al, 1982).…”

Neurogenic erectile dysfunction

“…The association of temporal lobe lesions and epileptic seizures with ED has been reported [26][27][28]. Herzog et al…”

“…have suggested that epileptic discharges in the medial temporal lobe may disrupt hypothalamic regulation of pituitary secretion and result in increased prolactin and decreased testosterone levels [27]. Epilepsy, while neurogenic in origin, can therefore result in endocrinologic ED.…”