Seizure associated with low-dose naloxone

Mariani, Peter J.

doi:10.1016/0735-6757(89)90119-8

Cited by 22 publications

(2 citation statements)

References 12 publications

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“…I pazienti più predisposti a sviluppare aumenti pressori risultano quelli con preesistente ipertensione e, tra questi, quelli in terapia con beta 2 -stimolanti: un rischio molto aumentato è possibile per i pazienti in trattamento con clonidina o metildopa 132 . Un caso di convulsioni da grande male si è avuto 30 secondi dopo la somministrazione di 0,8 mg di naloxone per via endovenosa in paziente affetto da linfo-ma non-Hodgkin per antagonizzare gli effetti della morfina somministrata a scopo antalgico 139 . Il solo episodio di laringospasmo dopo estubazione è stato descritto dopo somministrazione di 0,4 mg di naloxone nel postoperatorio in una paziente che aveva già avuto precedenti episodi di laringospasmo 140 .…”

Section: Controindicazioni Precauzioni Effetti Collaterali E Interazi...unclassified

Naloxone: intravenously, intramuscular, inhalatory and intranasal use in emergency cases

et al. 2005

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The use of naloxone in emergency medicine is primarily connected to the treatment of a syndrome known as overdose, which is cause by non-essential use of heroin and certain opioid agonists. The dose of naloxone required to be efficacious depends on the quantity of opioid assumed, its receptorial affinity and its kinetics: in propoxyphene and pentazocine intoxication, for instance, higher doses are require than those needed in the treatment of morphine or heroin overdose. Intravenous administration is the most efficacious and fast-acting method: however, in certain cases, and depending on aspects that are typical of overdose patient management (e.g. the difficulties connected to vein access, skin scarring, severe hypotension), alternative pathways may be used. These include intraand sub-lingual and intratracheale administration, inhalatory administration via nebulisation (possible in the presence of respiratory action only), and intramuscular and subcutaneaous administration (which are efficacious in the absence of hypoperfusion). However, the most promising means of administration would appear to be intranasal administration, thanks to the relative ease of access, lower risk of contact with bodily fluids and the excellent bioavailability and rapidity of the effect, which is similar to that achieved with intravenous administration

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Section: Controindicazioni Precauzioni Effetti Collaterali E Interazi...unclassified

Naloxone: intravenously, intramuscular, inhalatory and intranasal use in emergency cases

et al. 2005

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“…Seizures have been documented with the use of Naloxone in opioid toxicity, and studies concerning acute Tramadol toxicity have also documented an increased risk of seizure reoccurring after using of Naloxone. [23] In addition, even the efficacy of anticonvulsants in Tramadol-induced seizures is also debatable. [4] Acceptably, Eizadi-Mood et al .…”

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Aliyu

Kyari

Ibrahim

2017

Saudi J Med Med Sci

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The Poisoned Patient With Altered Consciousness

Hoffman

Goldfrank²

1995

JAMA

109

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Analysis favors empirical administration of hypertonic dextrose and thiamine hydrochloride to patients with altered consciousness. Although rapid reagent test strips can be used to guide this therapy, they are not infallible, and they fail to recognize clinical hypoglycemia that may occur without numerical hypoglycemia. Administration of naloxone hydrochloride should be reserved for patients with signs and symptoms of opioid intoxication. Flumazenil is best left for reversal of therapeutic conscious sedation and rare select cases of benzodiazepine overdose.

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Seizure associated with low-dose naloxone

Cited by 22 publications

References 12 publications

Naloxone: intravenously, intramuscular, inhalatory and intranasal use in emergency cases

Naloxone: intravenously, intramuscular, inhalatory and intranasal use in emergency cases

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The Poisoned Patient With Altered Consciousness

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