Seizure and coma secondary to Conn’s syndrome: a case report

Abstract

Background: Conn's syndrome is a curable condition if identified properly. It is characterized by autonomous secretion of aldosterone from the adrenal gland cortex. Its morbidity is related to the increased risk of cardiovascular diseases. Case presentation: We report the case of a 48-year-old man of African descent presenting with generalized tonicclonic seizure and coma secondary to hypertensive encephalopathy. A biochemical evaluation revealed a very high aldosterone level and an undetectable renin level, both are compatible with primary aldosteronism. The presentation of the following confirms the diagnosis of primary aldosteronism: spontaneous hypokalemia, an undetectable renin level, and a high aldosterone level. Abdominal computed tomography revealed a left adrenal adenoma. Adrenal venous sampling confirmed lateralization of aldosterone excretion from the left adrenal gland. Our patient underwent left laparoscopic adrenalectomy that confirmed a left functional adrenal adenoma. After 12 months of follow up, his hypertension was controlled on only one antihypertensive drug which was down from four drugs preoperatively. Conclusion: Conn's syndrome, in this case, was complicated by coma secondary to seizure. Adrenalectomy normalized the hypokalemia and improved resistant hypertension. Potassium supplementation and several antihypertensives were discontinued as our patient became normokalemic and normotensive on one antihypertensive agent.

Anesthetic Implications in Managing a Case of Primary Hyperaldosteronism: A Case Report

“…Untreated hypertension secondary to primary hyperaldosteronism could lead to acute complications like stroke, myocardial infarction, and intracranial bleed [ 12 ]. Manipulation of the adrenal gland during tumor removal may cause cardiovascular instability due to the secretion of catecholamines, although this is not as severe as with catecholamine-secreting tumors of the adrenal (pheochromocytoma) [ 13 ]. A short-acting alpha-blocker like phentolamine is very useful in controlling blood pressure in such situations.…”