Seizing the fate of lymph nodes in immunotherapy: To preserve or not?

Xu, Zhen-Yu; Li, Zi-Zhan; Cao, Lei-Ming; Zhong, Nian-Nian; Liu, Xuan-Hao; Wang, Guang-Rui; Xiao, Yao; Liu, Bing; Bu, Lin-Lin

doi:10.1016/j.canlet.2024.216740

Cancer Letters

2024

DOI: 10.1016/j.canlet.2024.216740

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Seizing the fate of lymph nodes in immunotherapy: To preserve or not?

Zhen-Yu Xu,

Zi-Zhan Li,

Lei-Ming Cao

et al.

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2024

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Cited by 3 publications

References 92 publications

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Lymph node metastasis in cancer: Clearing the clouds to see the dawn

Li,

Zhou,

et al. 2024

Critical Reviews in Oncology/Hematology

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Lymph node metastasis in cancer: Clearing the clouds to see the dawn

Li,

Zhou,

et al. 2024

Critical Reviews in Oncology/Hematology

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A 3 M Evaluation Protocol for Examining Lymph Nodes in Cancer Patients: Multi-Modal, Multi-Omics, Multi-Stage Approach

Wang,

Zhang,

Zhao

et al. 2024

Technol Cancer Res Treat

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Through meticulous examination of lymph nodes, the stage and severity of cancer can be determined. This information is invaluable for doctors to select the most appropriate treatment plan and predict patient prognosis; however, any oversight in the examination of lymph nodes may lead to cancer metastasis and poor prognosis. In this review, we summarize a significant number of articles supported by statistical data and clinical experience, proposing a standardized evaluation protocol for lymph nodes. This protocol begins with preoperative imaging to assess the presence of lymph node metastasis. Radiomics has replaced the single-modality approach, and deep learning models have been constructed to assist in image analysis with superior performance to that of the human eye. The focus of this review lies in intraoperative lymphadenectomy. Multiple international authorities have recommended specific numbers for lymphadenectomy in various cancers, providing surgeons with clear guidelines. These numbers are calculated by applying various statistical methods and real-world data. In the third chapter, we mention the growing concern about immune impairment caused by lymph node dissection, as the lack of CD8 memory T cells may have a negative impact on postoperative immunotherapy. Both excessive and less lymph node dissection have led to conflicting findings on postoperative immunotherapy. In conclusion, we propose a protocol that can be referenced by surgeons. With the systematic management of lymph nodes, we can control tumor progression with the greatest possible likelihood, optimize the preoperative examination process, reduce intraoperative risks, and improve postoperative quality of life.

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Lymph node metastasis diagnosis of postoperative OSCC patients by analyzing extracellular vesicles in drainage fluid based on microfluidic isolation

Li,

Cai,

Zhu

et al. 2024

J Nanobiotechnol

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Seizing the fate of lymph nodes in immunotherapy: To preserve or not?

Cited by 3 publications

References 92 publications

Lymph node metastasis in cancer: Clearing the clouds to see the dawn

Lymph node metastasis in cancer: Clearing the clouds to see the dawn

A 3 M Evaluation Protocol for Examining Lymph Nodes in Cancer Patients: Multi-Modal, Multi-Omics, Multi-Stage Approach

Lymph node metastasis diagnosis of postoperative OSCC patients by analyzing extracellular vesicles in drainage fluid based on microfluidic isolation

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