The sensitivity index plays a critical role in the design of product and is used to quantify the impact degree of the uncertainty of the input variable to the uncertainty of the interest output. This paper presents a new local reliability sensitivity method and a global reliability sensitivity analysis method of time-dependent reliability problems. Firstly, according to the Poisson's assumption-based first-passage method, the local reliability sensitivity index is directly obtained by calculating the partial derivative of the failure probability to the distribution parameters of input random variable. Then, the moment-independent global reliability sensitivity index of the time-dependent problems is derived based on the concept of moment-independent. Finally, the efficiency and accuracy of the proposed method are verified with the reference results of Monte Carlo simulation.