Aiming to address the problem of construction and environmental risks in tunnel construction through the soil–rock mixture backfill area, this paper carried out a seismic dynamic response model test of a pile-supported tunnel based on practical projects. Firstly, the stress–strain curves and failure characteristics of the soil–rock mixture in the study area were obtained through triaxial tests, and based on this, similar materials for the model test were developed. Then, a vibration table model test was devised to investigate the seismic dynamic response of the pile–tunnel structure. The findings revealed the following: when subjected to seismic waves, the soil–rock mixture stratum displayed a “skin effect” in its acceleration response, indicating that closer proximity to the surface led to heightened horizontal acceleration responses; the horizontal peak acceleration of the grouting mixture stratum in the vertical direction exhibited a “Zigzag” pattern; the peak values of strain response and bending moment in the tunnel lining cross-section exhibited an “X” shape and inverted “V” shape, respectively. The bending moment at the pile crown increased alongside the peak value of the input seismic wave acceleration. The maximum surface settlement in the model ranged from 0.5 to 1 cm, with the tunnel–pile structure effectively mitigating surface settlement.