Southern Romania experiences special soil conditions, leading to rather long corner periods and to an enlarged plateau of the response spectrum, with associated large displacement demands. Pulse-type ground acceleration records complete this unique seismic area. Research on the seismic behavior of structures built under these special conditions is limited and engineers are not comfortable with alternative solutions such as base isolation. This study investigates the seismic performance of a hospital building with the following two anti-seismic solutions: 1) stiffening, in line with the capacity design method and 2) base isolation. Base shear, structural drift and structural acceleration are compared for both approaches.