Segregation of donor cell mitochondrial DNA in gaur–bovine interspecies somatic cell nuclear transfer embryos, fetuses and an offspring

Imsoonthornruksa, Sumeth; Srirattana, Kanokwan; Phewsoi, W.; Tunwattana, Wanchai; Parnpai, Rangsun; Ketudat-Cairns, Mariena

doi:10.1016/j.mito.2012.07.108

Cited by 5 publications

(3 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2006) DQ459559 B. sauveli Hassanin and Ropiquet (2004) AY689189 B. javanicus Hassanin and Ropiquet (2007a , 2007b ) EF693797 B. javanicus Tanaka et al. (1996) D82889 B. gaurus Hassanin and Ropiquet (2007a , 2007b ) EF685910 B. gaurus Imsoonthornruksa et al. (2012) GU324988 B. gaurus Direct Submission FJ190152 Bubalus bubalis Williams et al.…”

Section: Methodsmentioning

confidence: 99%

Kouprey (Bos sauveli) genomes unveil polytomic origin of wild Asian Bos

et al. 2021

View full text Add to dashboard Cite

Summary The evolution of the genera Bos and Bison , and the nature of gene flow between wild and domestic species, is poorly understood, with genomic data of wild species being limited. We generated two genomes from the likely extinct kouprey ( Bos sauveli ) and analyzed them alongside other Bos and Bison genomes. We found that B. sauveli possessed genomic signatures characteristic of an independent species closely related to Bos javanicus and Bos gaurus . We found evidence for extensive incomplete lineage sorting across the three species, consistent with a polytomic diversification of the major ancestry in the group, potentially followed by secondary gene flow. Finally, we detected significant gene flow from an unsampled Asian Bos -like source into East Asian zebu cattle, demonstrating both that the full genomic diversity and evolutionary history of the Bos complex has yet to be elucidated and that museum specimens and ancient DNA are valuable resources to do so.

show abstract

Section: Methodsmentioning

confidence: 99%

Kouprey (Bos sauveli) genomes unveil polytomic origin of wild Asian Bos

et al. 2021

View full text Add to dashboard Cite

show abstract

“…That is why the production of nuclear-transferred embryos, fetuses, and offspring with a precisely defined profile of nucleotide sequences in regulatory or coding segments of the nuclear and/or mitochondrial genome seems to be valuable tool. This tool can be suitable for experimentally dissecting the effects of not only nuclear and cytoplasmic genetic/epigenetic components but also the intrauterine environment of recipient females on embryonic, fetal, and postnatal development of cloned specimens [2,155,158,171].…”

Section: Inheritance Of the Mitochondrial Genome And Intergenomic Commentioning

confidence: 99%

“…Different possible patterns/scenarios of extranuclear (cytoplasmic) inheritance of mtDNA fractions have been presented (see Figure 1 (for intraspecies cloning by SCNT) [2,158,165,172], Figure 2 (for interspecies SCNT using nuclear donor cells and recipient oocytes derived from closely related mammalian species) [163,170,171,173,174], and Figure 3 (for interspecies SCNT using nuclear donor cells and recipient oocytes derived from phylogenetically distant mammalian species) [162,164,175,176]).…”

Section: Inheritance Of the Mitochondrial Genome And Intergenomic Commentioning

confidence: 99%

Extranuclear Inheritance of Mitochondrial Genome and Epigenetic Reprogrammability of Chromosomal Telomeres in Somatic Cell Cloning of Mammals

Samiec

Skrzyszowska

2021

IJMS

View full text Add to dashboard Cite

The effectiveness of somatic cell nuclear transfer (SCNT) in mammals seems to be still characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny generated. These rates are measured in relation to the numbers of nuclear-transferred oocytes and can vary depending on the technique applied to the reconstruction of enucleated oocytes. The SCNT efficiency is also largely affected by the capability of donor nuclei to be epigenetically reprogrammed in a cytoplasm of reconstructed oocytes. The epigenetic reprogrammability of donor nuclei in SCNT-derived embryos appears to be biased, to a great extent, by the extranuclear (cytoplasmic) inheritance of mitochondrial DNA (mtDNA) fractions originating from donor cells. A high frequency of mtDNA heteroplasmy occurrence can lead to disturbances in the intergenomic crosstalk between mitochondrial and nuclear compartments during the early embryogenesis of SCNT-derived embryos. These disturbances can give rise to incorrect and incomplete epigenetic reprogramming of donor nuclei in mammalian cloned embryos. The dwindling reprogrammability of donor nuclei in the blastomeres of SCNT-derived embryos can also be impacted by impaired epigenetic rearrangements within terminal ends of donor cell-descended chromosomes (i.e., telomeres). Therefore, dysfunctions in epigenetic reprogramming of donor nuclei can contribute to the enhanced attrition of telomeres. This accelerates the processes of epigenomic aging and replicative senescence in the cells forming various tissues and organs of cloned fetuses and progeny. For all the above-mentioned reasons, the current paper aims to overview the state of the art in not only molecular mechanisms underlying intergenomic communication between nuclear and mtDNA molecules in cloned embryos but also intrinsic determinants affecting unfaithful epigenetic reprogrammability of telomeres. The latter is related to their abrasion within somatic cell-inherited chromosomes.

show abstract

Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction

Srirattana

John

2019

Cellular and Molecular Basis of Mitochondrial Inheritance

View full text Add to dashboard Cite

Segregation of donor cell mitochondrial DNA in gaur–bovine interspecies somatic cell nuclear transfer embryos, fetuses and an offspring

Cited by 5 publications

References 53 publications

Kouprey (Bos sauveli) genomes unveil polytomic origin of wild Asian Bos

Kouprey (Bos sauveli) genomes unveil polytomic origin of wild Asian Bos

Extranuclear Inheritance of Mitochondrial Genome and Epigenetic Reprogrammability of Chromosomal Telomeres in Somatic Cell Cloning of Mammals

Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction

Contact Info

Product

Resources

About