Segregation distortions for the ABO system in pairs of sibs

Abstract

The influence of maternal phenotype was observed in 471 consecutive sib pairs to explore the segregation distortions for the ABO system. The ABO typing was done using the standard technique of haemagglutination reaction and the sib pairs were named according to their phenotypes. Thus A-B is the pair where first sib was A and the consecutive one was B. The statistical computations involved calculations of ABO gene frequencies, and application of chi-square and Z test for proportions to study the segregation distortions in sibs. A significant excess of B gene in the first sib and reduction of O in the second sib was observed when the Z test was applied to study the covariance, whereas no significant distortions were observed with simple Chi-square test. Heterozygote AO mothers segregated insignificantly in favour of A allele whereas BO mothers segregated significantly in favour of B allele in the first as well as in the second sib indicating that selection is favouring the B gene in our population.

Maternal fetal interaction in the ABO system: A comparative analysis of healthy mother and couples with spontaneous abortion in Bengalee population

“…Three principles but not mutually exclusive mechanism such as mortality of the genotype (Levine,1943; Weiner,1942; Aird et al,1953; Bandyopadhyay,1992a,b; Bottini et al,2001), distortion of segregation ratios (Hirzfeld and Zoborowski,1925; Kirk et al, 1955; Bottini et al,1998; Banerjee and Das,1986; Virdhi and Kaur,1998) and differential fertility of different genotypes (Matsunaga and Etoh,1958; Matsunaga and Hiraizumi,1962; Nag and Banerjee,1976; Schaap et al,1984; Berberovic et al,2004) were thought to be responsible for the maintenance of polymorphism (Solish,1969; Cavalli‐Sfroza and Bodmer,1971; Chester and Olsson,2001) in ABO blood group as genetic marker traits and as well as multiple polymorphisms in noncoding regions (Seltsam et al,2003). A number of studies worldwide (Levine and Rosenfield,1961; Hirazumi et al,1973; Gualtieri et al,1985; Bottini et al,2001) as well as in India (Chakravartti and Chakravartti,1978; Satyanarayana et al, 1998; Banerjee,1989; Bandyopadhyay,1992a,b; Bandyopadhyay and Ghoshal Roy,2002; Sharma and Kapoor,2004) on ABO blood groups with regard to the operational processes for selection has been demonstrated.…”