Segregation and fertility in Mus musculus domesticus (wild mice) heterozygous for the Rb(4.12) translocation

Viroux, Marie-Cecile; Bauchau, Vincent

doi:10.1038/hdy.1992.20

Cited by 26 publications

(20 citation statements)

References 14 publications

(15 reference statements)

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“…In some instances a single heterozygous rearrangement may be sufficient to adversely affect fertility (Hauffe & Searle 1998), while in others those carrying few heterozygous rearrangements do not generally show a decrease in fertility (Winking et al 1988, Viroux & Bauchau 1992, Wallace et al 1992). On the contrary, however, hybrids heterozygous for more than three rearrangements generally show elevated levels of aneuploidy and/or germ cell death (Redi & Capanna 1978, Saïd et al 1993.…”

Section: Chromosomal Speciation In Microgalementioning

confidence: 97%

Chromosomal evolution in tenrecs (Microgale and Oryzorictes, Tenrecidae) from the Central Highlands of Madagascar

et al. 2007

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Tenrecs (Tenrecidae) are a widely diversified assemblage of small eutherian mammals that occur in Madagascar and Western and Central Africa. With the exception of a few early karyotypic descriptions based on conventional staining, nothing is known about the chromosomal evolution of this family. We present a detailed analysis of G-banded and molecularly defined chromosomes based on fluorescence in situ hybridization (FISH) that allows a comprehensive comparison between the karyotypes of 11 species of two closely related Malagasy genera, Microgale (10 species) and Oryzorictes (one species), of the subfamily Oryzorictinae. The karyotypes of Microgale taiva and M. parvula (2n = 32) were found to be identical to that of O. hova (2n = 32) most likely reflecting the ancestral karyotypes of both genera, as well as that of the Oryzorictinae. Parsimony analysis of chromosomal rearrangements that could have arisen following Whole Arm Reciprocal Translocations (WARTs) showed, however, that these are more likely to be the result of Robertsonian translocations. A single most parsimonious tree was obtained that provides strong support for three species associations within Microgale, all of which are consistent with previous molecular and morphological investigations. By expanding on a recently published molecular clock for the Tenrecidae we were able to place our findings in a temporal framework that shows strong chromosomal rate heterogeneity within the Oryzorictinae. We use these data to critically examine the possible role of chromosomal rearrangements in speciation within Microgale.

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Section: Chromosomal Speciation In Microgalementioning

confidence: 97%

Chromosomal evolution in tenrecs (Microgale and Oryzorictes, Tenrecidae) from the Central Highlands of Madagascar

et al. 2007

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“…Field and laboratory studies on structural heterozygotes derived from wild popula- tions have shown that the presence of one, two or three trivalents at meiosis may have little effect on fertility Scriven, 1992;Viroux and Bauchau, 1992;Wallace et al, 1992). In contrast, many trivalents, in multiple single heterozygotes or long chains or rings in complex heterozygotes, may reduce fertility to the point of sterility.…”

Section: Effectiveness Of the Post-mating Barriermentioning

confidence: 99%

Chromosomes and speciation in <i>Mus musculus domesticus</i>

Capanna¹,

Castiglia²

2004

Cytogenet Genome Res

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Thirty years after its identification, the model of chromosomal speciation in Mus musculus domesticus is reevaluated using the methods of population biology, molecular cytogenetics and functional genomics. Three main points are considered: (1) the structural predisposition of M. m. domesticus chromosomes to Robertsonian fusion; (2) the impediment of structural heterozygosity to gene flow between populations of mice with karyotypes rearranged by Robertsonian fusion and between them and populations with the standard all-acrocentric 40-chromosome karyotype; (3) the selective advantage of chromosomal novelty, essential for the attainment of homozygosis and the rapid fixation of the new karyotype in the population.

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“…Our results indicate that neither meiotic disjunction nor hybrid sterility or hybrid breakdown exists between the reciprocal crosses of the two karyotypes investigated here or among the backcrosses of these hybrids. Although our study is not unique in reporting the lack of a hybrid disadvantage between different kayotypes with centric fusions (Nachman & Meyers, 1989; Viroux & Bauchau, 1992; Hauffe & Searle, 2002), the large difference in the diploid number between the two S. campestris karyotypes (2 n =32 and 2 n =46) is exceptional. For instance, the diploid number in the rodent Holochilus brasiliensis reported by Nachman & Meyers (1989) ranged from 48 to 52, while the variation in the diploid number in the case of the mole rat Spalax ehrenbergi was 52–60 (Nevo, Filippucci & Beiles, 1994).…”

Section: Discussionmentioning

confidence: 73%

“…However, litter size was constant for our crosses (Table 2A), indicating that neither the karyotypic hybrids nor their offspring suffered any disadvantage when compared with the pure lines. Reduced litter size occurs in chromosomal heterozygotes of M. musculus (Said et al ., 1993; Hauffe & Searle, 2002), as well as in other rodents (Theiler & Blanco, 1996), but not in litter sizes of karyotypes in the centric fusion system of M. musculus hybrid zones (Britton‐Davidian et al ., 1990; Viroux & Bauchau, 1992; Hauffe & Searle, 2002). Clearly, the karyotypic composition of an individual is not sufficient to affect litter size: other conditions need to apply in addition to a hybrid karyotype (Hauffe & Searle, 2002).…”

Section: Discussionmentioning

confidence: 99%

Strong hybrid viability between two widely divergent chromosomal forms of the pouched mouse

et al. 2011

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A large degree of karyotypic diversity in the pouched mouse Saccostomus campestris, ranging from 2n =28 to 2n = 46, is mostly due to centric fusions. The taxon comprises a complex of cryptic species, of which the 2n= 32 and 2n =46 karyotypes represent two different species. Crossbreeding pure 2n= 32 and pure 2n = 46 karyotypes up to the F3 hybrid generation yielded F1 hybrids with 39 chromosomes, seven of which were unpaired. Unpaired chromosomes ranged in size from very long to short. We measured the growth rate, testis structure and litter size of these crosses and did not find any indication that the F1, F2 or F3 generations exhibit any degree of hybrid disadvantage or hybrid breakdown. The interpretation of these results is strongly affected by the species concept used, but weakens the conclusions of several other authors that S. campestris in southern Africa comprises a complex of cryptic species.

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Segregation and fertility in Mus musculus domesticus (wild mice) heterozygous for the Rb(4.12) translocation

Abstract: Analysis of the progeny of wild mice heterozygous for the Rb(4.12) shows that fertility and segregation are normal. This study, and others with similar results, suggests that our view of the chromosomal evolution of the house mouse should be revised.

Cited by 26 publications

References 14 publications

Chromosomal evolution in tenrecs (Microgale and Oryzorictes, Tenrecidae) from the Central Highlands of Madagascar

Chromosomal evolution in tenrecs (Microgale and Oryzorictes, Tenrecidae) from the Central Highlands of Madagascar

Chromosomes and speciation in <i>Mus musculus domesticus</i>

Strong hybrid viability between two widely divergent chromosomal forms of the pouched mouse

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