Segregating polymorphism in the NMDA receptor gene GRIN2A, schizotypy, and mental rotation among healthy individuals

Jha, Siddharth; Read, Silven; Hurd, Peter L.; Crespi, Bernard J.

doi:10.1016/j.neuropsychologia.2018.06.021

Cited by 2 publications

(6 citation statements)

References 40 publications

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“…Regarding schizotypy and mental rotation, no relationship was found between them. Our results are similar to those reported by Jha, Read, Hurd and Crespi (2018) with undergraduate students, as SPQ scores were not associated with performance in a novel mental rotation task. Considering the psychosis continuum (DeRosse & Karlsgodt, 2015), it is expected that clinical populations could show psychotic symptoms at higher severity than non‐clinical populations, such as university students, which might not present enough severity of these traits to affect their visuospatial abilities (Martin & Fleming, 2019).…”

Section: Discussionsupporting

confidence: 91%

“…It is worth noting that the importance of the employed analytical approach could be decisive to draw conclusions. When literature is not consistent regarding the existence of a relationship between two variables, such as the case of schizotypy and mental rotation (e.g., Jha, Read, Hurd & Crespi, 2018; Steinisch et al ., 2011; Thakkar & Park, 2010; Vastano, Sulpizio, Steinisch, Comani & Committeri, 2014), the effect size should also be taken into account to ensure that the effect is not spurious or due to randomness. As explained above, the use of HDIs and ROPEs using a Bayesian approach may be useful for this purpose (Kruschke, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…(2011) reported improved performance in both men and women with high global schizotypy that were also measured with the SPQ in an array and self‐mental rotation task. On the contrary, Vastano, Sulpizio, Steinisch, Comani and Committeri (2014) detected a negative relationship between mental rotation performance and Cognitive‐perceptual scores in the SPQ, while other studies (e.g., Jha, Read, Hurd & Crespi, 2018) have found spared – but neither enhanced nor impaired – mental rotation in people with high schizotypy. Thus, it can be concluded that more research is needed to better elucidate the relationship between schizotypy and mental rotation performance.…”

Section: Introductionmentioning

confidence: 89%

“…Since our goal was to detect subtle effects (Ettinger et al ., 2015) that might not appear if they were beneficial and the task was easy, or if they were impairing and the task was hard (as we could not presume the direction of a possible schizotypy‐mental rotation relationship), the use of a task that features two distinct difficulty levels, which most studies do not utilize, is required. Although the direction of this possible schizotypy‐mental rotation relationship cannot be presumed due to previous contradictory findings (Jha, Read, Hurd & Crespi, 2018; Steinisch et al ., 2011; Thakkar & Park, 2010; Vastano, Sulpizio, Steinisch, Comani & Committeri, 2014), it is expected to find sex differences in the mental rotation task, as this is a typical result in mental rotation paradigms (Boone & Hegarty, 2017).…”

Section: Introductionmentioning

confidence: 91%

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Mental rotation and schizotypal personality traits: A Bayesian approach

García-Pérez

González‐Rodríguez

Godoy-Giménez

et al. 2022

Scandinavian J Psychology

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People diagnosed with schizophrenia exhibit mental rotation differences, suggesting that clinical levels of positive symptoms, such as psychotic hallucinations, are related to disruptions in their monitoring and manipulation of mental representations. According to the psychosis continuum, findings in people with a high level of schizotypal personality traits are expected to be qualitatively similar, but research concerning this topic is scarce. A spared mental imagery manipulation in this population only could suggest that this ability might be a possible protective factor, or that the emergence of clinical‐level positive symptoms could be paired with disruptions in this capacity. To explore this issue, 205 undergraduate students (122 women) completed a novel mental rotation task identifying the stimulus that was a 90, 180, or 270° rotation of a black circle with colored portions and were assessed with the Schizotypal Personality Questionnaire. Men performed better in most conditions. No relationship was detected between schizotypal personality traits and accuracy in the task. These results do not support that mental imagery manipulation disruptions may be related to schizotypal personality traits in non‐clinical populations. Thus, they might instead be associated with the onset of psychosis disorders as mental representation handling is hindered. However, additional research is required including the general population, as well as those with higher levels of psychotic symptoms and psychosis disorders. Future research could also focus on working memory processes related to mental representation manipulations of different sensory modalities such as auditory mental representations and their relationship with schizotypal personality traits and clinical populations.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 91%

See 2 more Smart Citations

Mental rotation and schizotypal personality traits: A Bayesian approach

García-Pérez

González‐Rodríguez

Godoy-Giménez

et al. 2022

Scandinavian J Psychology

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“…The rat model has shown that GRIN2A expression is altered in the prefrontal cortex during earlier stages of development, which could impact symptom severity [ 43 ]. Literature associating GRIN2A common polymorphisms with schizophrenia implies that more mild changes in expression also contribute to neuropsychiatric disorder etiology [ 33 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants

Hojlo

Ghebrelul

Genetti

et al. 2023

Genes

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Background: Children and adolescents with early-onset psychosis (EOP) have more rare genetic variants than individuals with adult-onset forms of the illness, implying that fewer EOP participants are needed for genetic discovery. The Schizophrenia Exome Sequencing Meta-analysis (SCHEMA) study predicted that 10 genes with ultra-rare variation were linked to adult-onset schizophrenia. We hypothesized that rare variants predicted “High” and “Moderate” by the Variant Effect Predictor Algorithm (abbreviated as VEPHMI) in these 10 genes would be enriched in our EOP cohort. Methods: We compared rare VEPHMI variants in individuals with EOP (N = 34) with race- and sex-matched controls (N = 34) using the sequence kernel association test (SKAT). Results: GRIN2A variants were significantly increased in the EOP cohort (p = 0.004), with seven individuals (20% of the EOP cohort) carrying a rare VEPHMI variant. The EOP cohort was then compared to three additional control cohorts. GRIN2A variants were significantly increased in the EOP cohort for two of the additional control sets (p = 0.02 and p = 0.02), and trending towards significance for the third (p = 0.06). Conclusion: Despite a small sample size, GRIN2A VEPHMI variant burden was increased in a cohort of individuals with EOP in comparison to controls. GRIN2A variants have been associated with a range of neuropsychiatric disorders including adult-onset psychotic spectrum disorder and childhood-onset schizophrenia. This study supports the role of GRIN2A in EOP and emphasizes its role in neuropsychiatric disorders.

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Segregating polymorphism in the NMDA receptor gene GRIN2A, schizotypy, and mental rotation among healthy individuals

Cited by 2 publications

References 40 publications

Mental rotation and schizotypal personality traits: A Bayesian approach

Mental rotation and schizotypal personality traits: A Bayesian approach

Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants

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