Segregating domain-general from emotional context-specific inhibitory control systems - ventral striatum and orbitofrontal cortex serve as emotion-cognition integration hubs

Zhuang, Qian; Lei, Xu; Zhou, Feng; Yao, Shuxia; Zheng, Xiaoxiao; Zhou, Xinqi; Li, Jialin; Xu, Xiaoling; Fu, Meina; Li, Keshuang; Vatansever, Deniz; Kendrick, Keith M.; Becker, Benjamin

doi:10.1016/j.neuroimage.2021.118269

Cited by 36 publications

(32 citation statements)

References 92 publications

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“…To implement dimensional neuroimaging in a large sample we capitalized on the Chengdu Gene Brain Behavior Project which aims at determining psychopathological, genetic and neural alterations in a large cohort of healthy individuals (Liu et al, 2021; Montag et al, 2017b). N = 250 subjects from this project underwent multimodal MRI imaging, including a pain empathy paradigm (Li et al, 2019; Xu et al, 2020; Zhou et al, 2020a), an affective Go/No-go paradigm (Zhuang et al, 2021) as well as resting state and brain structural assessments (e.g. Liu et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: a dimensional neuroimaging approach

Lei

et al. 2022

Preprint

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BackgroundAccumulating evidence suggests brain structural and functional alterations in Internet Use Disorder (IUD). However, conclusions are strongly limited due to the retrospective case-control design of the studies, small samples, and the focus on general rather than symptom-specific approaches.MethodsWe here employed a dimensional multi-methodical MRI-neuroimaging design in a final sample of n = 203 subjects to examine associations between levels of IUD and its symptom-dimensions (loss of control/time management, craving/social problems) with brain structure, resting state and task-based (pain empathy, affective go/no-go) brain function.ResultsAlthough the present sample covered the entire range of IUD, including normal, problematic as well as pathological levels, general IUD symptom load was not associated with brain structural or functional alterations. However, the symptom-dimensions exhibited opposing associations with the intrinsic and structural organization of the brain, such that loss of control/time management exhibited negative associations with intrinsic striatal networks and hippocampal volume, while craving/social problems exhibited a positive association with intrinsic striatal networks and caudate volume.ConclusionsOur findings provided the first evidence for IUD symptom-domain specific associations with progressive alterations in the intrinsic structural and functional organization of the brain, particularly of striatal systems involved in reward, habitual and cognitive control processes.

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Section: Methodsmentioning

confidence: 99%

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: a dimensional neuroimaging approach

Lei

et al. 2022

Preprint

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“…N=250 healthy right-handed participants were enrolled in the current study and underwent a validated Go/NoGo fMRI paradigm. The data has been previously used to examine undirected functional connectivity within domain-general and emotion-specific inhibitory brain systems (Zhuang et al, 2021) and was part of larger neuroimaging project examining pain empathy (Li et al, 2018; Zhou et al, 2020), emotional face memory (Liu et al, 2022) and mirror neuron processing (Xu et al, 2022). After quality assessment n=218 subjects were included (104 males, Supplementary Materials ).…”

Section: Methodsmentioning

confidence: 99%

“…A validated mixed event-related block design linguistic emotional Go/NoGo fMRI paradigm was employed (Goldstein et al, 2007; Protopopescu et al, 2005, details see Zhuang et al, 2021). Participants were required to make responses as accurately and quickly as possible based on orthographical cues, i.e.…”

Section: Methodsmentioning

confidence: 99%

“…Each Go block encompassed 18 normal font words (100% Go trials) while each NoGo block encompassed 12 normal font words (66.7% Go trials) and 6 italicized font words (33.3% NoGo trials). Further details in (Zhuang et al, 2021) and Supplementary Materials .…”

Section: Methodsmentioning

confidence: 99%

“…To determine the causal information flow and critical nodes in the basal ganglia-thalamocortical circuits and whether these are modulated by biological factors (i.e. sex) and show functional relevance in terms of associations with performance we capitalized on DCM-PEB in combination with functional magnetic resonance imaging (fMRI) data collected in a large sample of healthy individuals (n=218) during a well-established response inhibition paradigm (emotional Go/NoGo task, see also Zhuang et al, 2021). To unravel the key nodes and causal influences within the inhibitory control network, we firstly estimated the effective connectivity between and within key regions involved in response inhibitory control within the rIFG-rCau-rGP-rThal functional circuit (right lateralized model) and secondly estimated sex differences and behavioral performance effects on connectivity parameters.…”

Section: Introductionmentioning

confidence: 99%

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The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit

Zhuang

Qiao

Lei

et al. 2022

Preprint

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The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed casual regulation within this inhibitory circuit in humans remains controversial. Here, we capitalize on the recent progress in robust and biologically plausible directed causal modelling (DCM-PEB) and a large response inhibition dataset (n=218; 104 males) acquired with concomitant functional fMRI to determine key nodes, their causal regulation and modulation via biological variables (sex) and inhibitory performance in the inhibitory circuit encompassing the right inferior frontal gyrus (rIFG), caudate nucleus (rCau), globus pallidum (rGP) and thalamus (rThal). The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and rThal. Direct comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and rThal. In addition, sex and performance influenced the architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation, while better inhibitory performance was associated with stronger rThal to rIFG communication. Furthermore, control analyses did not reveal a similar key communication in a left lateralized model. Together these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.

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Self-esteem and cortical thickness correlate with aggression in healthy children: A surface‐based analysis

Wu,

Guo,

Zhang

et al. 2024

Behavioural Brain Research

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Segregating domain-general from emotional context-specific inhibitory control systems - ventral striatum and orbitofrontal cortex serve as emotion-cognition integration hubs

Cited by 36 publications

References 92 publications

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: a dimensional neuroimaging approach

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: a dimensional neuroimaging approach

The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit

Self-esteem and cortical thickness correlate with aggression in healthy children: A surface‐based analysis

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