Segregated Systems of Human Brain Networks

Wig, Gagan S.

doi:10.1016/j.tics.2017.09.006

Cited by 277 publications

(312 citation statements)

References 128 publications

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“…Previous investigations dealing with the relationships between tasks and the resting state have compared the functional connectivity during cognitive tasks with that measured during the resting state (Cole et al 2014; Gerchen and Kirsch 2017), as reviewed by Wig (2017). Reports more closely related to the approach used herein have compared resting-state connectivity and hemispheric activation asymmetries obtained during language production in healthy individuals (Joliot et al 2016) and epileptic patients (Doucet et al 2014), or during story listening (Raemaekers et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…All but six participants were also mapped during the resting state. Most investigations of the resting-state and task-induced activation networks have relied on whole-brain comparisons between the functional connectivities measured in these two conditions [review in Wig (2017)], although they correspond to very different physiological states (Raichle and Mintun 2006; Raichle 2015). Here, we aimed to find resting-state markers of left hemisphere activation in discrete language areas to provide a comprehensive tool for further research on the inter-individual variability of language areas.…”

Section: Introductionmentioning

confidence: 99%

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A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers

et al. 2018

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We herein propose an atlas of 32 sentence-related areas based on a 3-step method combining the analysis of activation and asymmetry during multiple language tasks with hierarchical clustering of resting-state connectivity and graph analyses. 144 healthy right-handers performed fMRI runs based on language production, reading and listening, both with sentences and lists of over-learned words. Sentence minus word-list BOLD contrast and left-minus-right BOLD asymmetry for each task were computed in pairs of homotopic regions of interest (hROIs) from the AICHA atlas. Thirty-two hROIs were identified that were conjointly activated and leftward asymmetrical in each of the three language contrasts. Analysis of resting-state temporal correlations of BOLD variations between these 32 hROIs allowed the segregation of a core network, SENT_CORE including 18 hROIs. Resting-state graph analysis applied to SENT_CORE hROIs revealed that the pars triangularis of the inferior frontal gyrus and the superior temporal sulcus were hubs based on their degree centrality (DC), betweenness, and participation values corresponding to epicentres of sentence processing. Positive correlations between DC and BOLD activation values for SENT_CORE hROIs were observed across individuals and across regions regardless of the task: the more a SENT_CORE area is connected at rest the stronger it is activated during sentence processing. DC measurements in SENT_CORE may thus be a valuable index for the evaluation of inter-individual variations in language areas functional activity in relation to anatomical or clinical patterns in large populations. SENSAAS (SENtence Supramodal Areas AtlaS), comprising the 32 supramodal sentence areas, including SENT_CORE network, can be downloaded at http://www.gin.cnrs.fr/en/tools/.Electronic supplementary materialThe online version of this article (10.1007/s00429-018-1810-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers

et al. 2018

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“…frontoparietal regions) that support complex cognitive inferences. The effective brain function is supported by the maintenance of subnetworks segregation as well as their integration (Wig, 2017). Therefore, the diminished network differentiation would unavoidably result in ineffective functional specialization, leading to a blurred boundary between externally oriented immediate environment and internally abstract cognitive processing (Murphy et al, 2018;Northoff and Duncan, 2016), which further contributes to the inefficient integration of bottom-up sensory information with top-down processes.…”

Section: Inefficient Integration Of Bottom-up Sensory Information Witmentioning

confidence: 99%

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Dong

Yao

Wang

et al. 2020

Preprint

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For decades, schizophrenia has been primarily conceptualized as a disorder of high-order cognitive functions with deficits in executive brain regions. Yet due to the increasing reports of early sensory processing deficit, recent models focus more on the developmental effects of impaired sensory process on high-order functions. The present study examined whether this pathological interaction relates to an overarching system-level imbalance, specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. We applied a novel combination of connectome gradient and stepwise connectivity analysis to resting-state functional magnetic resonance imaging (rsfMRI) to characterize the sensorimotor-to-transmodal cortical hierarchy organization (96 patients vs. 122 controls). Using these techniques, we demonstrated compression of the cortical hierarchy organization in schizophrenia, with a prominent compression from the sensorimotor region and a less prominent compression from the frontal-parietal region, resulting in a diminished separation between sensory and fronto-parietal cognitive systems. Further analyses suggested reduced differentiation related to atypical functional connectome transition from unimodal to transmodal brain areas. Specifically, we found hypo-connectivity within unimodal regions and hyper-connectivity between unimodal regions and frontoparietal and ventral attention regions along the classical sensation-to-cognition continuum established in prior neuroanatomical work. The compression of cortical hierarchy organization represents a novel and integrative system-level substrate underlying the pathological interaction of early sensory and cognitive function in schizophrenia. This abnormal cortical hierarchy organization suggests cascaded impairments stemming from the disrupted somatosensory-motor system and inefficient integration of bottom-up sensory information with attentional demands and executive control processes partially account for high-level cognitive deficits characteristic of schizophrenia.

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“…Modular brain architecture is thought to enable efficient processing and flow of information (Bullmore & Sporns, 2009). Studies of aging and disease have provided evidence for the important of modular brain systems to cognitive function (for a review, see Wig, 2017). …”

Section: Introductionmentioning

confidence: 99%

Re-emergence of modular brain networks in stroke recovery

Siegel

Seitzman

Ramsey

et al. 2018

Cortex

184

240

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Studies of stroke have identified local reorganization in perilesional tissue. However, because the brain is highly networked, strokes also broadly alter the brain's global network organization. Here, we assess brain network structure longitudinally in adult stroke patients using resting state fMRI. The topology and boundaries of cortical regions remain grossly unchanged across recovery. In contrast, the modularity of brain systems i.e. the degree of integration within and segregation between networks, was significantly reduced sub-acutely (n = 107), but partially recovered by 3 months (n = 85), and 1 year (n = 67). Importantly, network recovery correlated with recovery from language, spatial memory, and attention deficits, but not motor or visual deficits. Finally, in-depth single subject analyses were conducted using tools for visualization of changes in brain networks over time. This exploration indicated that changes in modularity during successful recovery reflect specific alterations in the relationships between different networks. For example, in a patient with left temporo-parietal stroke and severe aphasia, sub-acute loss of modularity reflected loss of association between frontal and temporo-parietal regions bi-hemispherically across multiple modules. These long-distance connections then returned over time, paralleling aphasia recovery. This work establishes the potential importance of normalization of large-scale modular brain systems in stroke recovery.

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Segregated Systems of Human Brain Networks

Cited by 277 publications

References 128 publications

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Re-emergence of modular brain networks in stroke recovery

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