Segmented poly(urethane‐urea) elastomers based on polycaprolactone: Structure and properties

May-Hernandez, L. H.; Hernández-Sánchez, Fernando; Ribelles, J. L. Gomez; Serra, Roser Sabater i

doi:10.1002/app.32929

Cited by 35 publications

(30 citation statements)

References 32 publications

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“…7. The hypothesis of spacing promoted by a lateral packing of the HS and partially stretched or perturbed conformations of the SS, claimed due to the small values of SAXS spacing and AFM observations for the urea, were confirmed by these results [61].…”

Section: Molecular Dynamics Studies Of Multi Chainssupporting

confidence: 56%

Multiscale Modeling of the Morphology and Properties of Segmented Silicone-Urea Copolymers

Yıldırım

Yurtsever

et al. 2011

J Inorg Organomet Polym

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Molecular dynamics and mesoscale dynamics simulation techniques were used to investigate the effect of hydrogen bonding on the microphase separation, morphology and various physicochemical properties of segmented silicone-urea copolymers. Model silicone-urea copolymers investigated were based on the stoichiometric combinations of a,x-aminopropyl terminated polydimethylsiloxane (PDMS) oligomers with number average molecular weights ranging from 700 to 15,000 g/mole and bis(4-isocyanatocyclohexyl)methane (HMDI). Urea hard segment contents of the copolymers, which were determined by the PDMS molecular weight, were in 1.7-34% by weight range. Since no chain extenders were used, urea hard segments in all copolymers were of uniform length. Simulation results clearly demonstrated the presence of very good microphase separation in all silicone-urea copolymers, even for the copolymer with 1.7% by weight hard segment content. Experimentally reported enhanced properties of these materials were shown to stem from strong hydrogen bond interactions which leads to the aggregation of urea hard segments and reinforcement of the PDMS.

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Section: Molecular Dynamics Studies Of Multi Chainssupporting

confidence: 56%

Multiscale Modeling of the Morphology and Properties of Segmented Silicone-Urea Copolymers

Yıldırım

Yurtsever

et al. 2011

J Inorg Organomet Polym

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“…[3][4][5] Our group has recently synthesized a novel polycaprolactone (PCL) based polyurethane-urea (PUU) copolymer with putrescine as the chain extender. 6 Chain extenders are low molecular mass compounds (hydroxyl and/or amine terminated) that play an important role not only in the morphology of segmented polyurethane (hard segments of these elastomeric polymers are formed by the reaction between the chain extender and di-isocyanate), but also during polyurethane degradation. 7,8 Putrescine is a chemical compound that is present during the natural growth and differentiation of cells.…”

Section: Introductionmentioning

confidence: 99%

“…7,11 The synthesized biodegradable PCL based PUU displayed improved mechanical properties compared with its previously published counterparts; highly tailorable based on the ratio of the incorporated hard (polyurethane) and soft (PCL) segments. 6 By optimizing this ratio, our group has created a PUU copolymer that is capable of approximately 750% deformation before rupture, and possesses an elastic modulus (70 kPa) ideal for the mechanically demanding environment of cardiac tissue engineering applications. 6 The aim of this study was to explore whether indirect 3D printing could provide a means to fabricate this novel PCL based PUU polymer into a scaffold suitable for cardiac tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…6 By optimizing this ratio, our group has created a PUU copolymer that is capable of approximately 750% deformation before rupture, and possesses an elastic modulus (70 kPa) ideal for the mechanically demanding environment of cardiac tissue engineering applications. 6 The aim of this study was to explore whether indirect 3D printing could provide a means to fabricate this novel PCL based PUU polymer into a scaffold suitable for cardiac tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

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Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Hernández‐Córdova

Mathew

Balint

et al. 2016

J. Biomed. Mater. Res.

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Biomaterial scaffolds are a key part of cardiac tissue engineering therapies. The group has recently synthesized a novel polycaprolactone based polyurethane‐urea copolymer that showed improved mechanical properties compared with its previously published counterparts. The aim of this study was to explore whether indirect three‐dimensional (3D) printing could provide a means to fabricate this novel, biodegradable polymer into a scaffold suitable for cardiac tissue engineering. Indirect 3D printing was carried out through printing water dissolvable poly(vinyl alcohol) porogens in three different sizes based on a wood‐stack model, into which a polyurethane‐urea solution was pressure injected. The porogens were removed, leading to soft polyurethane‐urea scaffolds with regular tubular pores. The scaffolds were characterized for their compressive and tensile mechanical behavior; and their degradation was monitored for 12 months under simulated physiological conditions. Their compatibility with cardiac myocytes and performance in novel cardiac engineering‐related techniques, such as aggregate seeding and bi‐directional perfusion, was also assessed. The scaffolds were found to have mechanical properties similar to cardiac tissue, and good biocompatibility with cardiac myocytes. Furthermore, the incorporated cells preserved their phenotype with no signs of de‐differentiation. The constructs worked well in perfusion experiments, showing enhanced seeding efficiency. © 2016 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1912–1921, 2016.

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“…Los SR son bloques formados por la reacción de un disocianato con una diamina o diol de bajo peso molecular, mientras que los SS son bloques de un poliol de alto peso molecular (Figura 1). Saunders et al (1963) y May et al (2011) corroboraron que la inmiscibilidad entre SS-SR induce la separación de microfases (dominios), que es un factor que influye en gran medida en las propiedades de estos copolímeros multibloque La presencia de reacciones uretano, urea, biurete y alofanatos son de naturaleza covalente y razonablemente fuertes, cuyas estabilidades dependen de los componentes y las condiciones utilizadas (Tschan et al, 2012;Kardomenos y Kresta, 1981;Wen et al, 2000). Estos segmentos causan una separación de fases como resultado de su polaridad, característica que los hace útiles en diversas aplicaciones (Jeong et al, 2000;Ahmad et al, 2004).…”

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Efecto de la morfología en la degradación hidrolítica de Películas de poliuretano-urea segmentados

May-Hernandez

Reyes-Márquez

Lira-Maas

2019

iit

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ResumenLa estabilidad hidrolítica de una serie de polímeros de Poliuretanourea segmentado (PUUs) fue estudiada bajo degradación in vitro en buffer de fosfato salino (PBS) con pH de 7.4 y 37 °C durante 20 semanas. La degradación y las propiedades mecánicas de los productos finales fueron controladas por el contenido de segmentos rígidos y el tratamiento cercano a la temperatura de fusión del glicol utilizado. La asociación de los segmentos rígidos se incrementó usando diisocianato y dioles lineales. Las interacciones moleculares promovieron diversas respuestas viscoelásticas, que a su vez, fueron influenciadas por el envejecimiento térmico promovido en las cercanías del glicol. Los estudios de degradación se realizaron en películas delgadas obtenidas por evaporación lenta del solvente. Los PUUs fueron caracterizados mediante técnicas de espectroscopia de IR, calorimetría, análisis dinámico-mecánico y difracción de rayos X. Descriptores: Poliuretanourea, separación de fase, segmentos rígidos, degradación hidrolítica, microdominios. AbstractThe hydrolytic stability of a series of segmented polyurethaneurea polymers (PUUs) was studied under in vitro degradation in phosphate buffer saline (PBS) at pH 7.4 and 37 °C for 20 weeks. Degradation and the mechanical properties of the final products were monitored by the content of rigid segments and the treatment near the melting temperature of the glycol used. The association of the hard segments was increased using diisocyanate and linear diols, which causes various viscoelastic responses when it is influenced by heat aging near the glycol used. Degradation studies were performed on thin films obtained by slow evaporation of solvent. The PUUs were characterized by techniques of infrared spectroscopy, differential scanning calorimetry, dynamic mechanical analysis and X-ray diffraction.

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Segmented poly(urethane‐urea) elastomers based on polycaprolactone: Structure and properties

Cited by 35 publications

References 32 publications

Multiscale Modeling of the Morphology and Properties of Segmented Silicone-Urea Copolymers

Multiscale Modeling of the Morphology and Properties of Segmented Silicone-Urea Copolymers

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Efecto de la morfología en la degradación hidrolítica de Películas de poliuretano-urea segmentados

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