Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

Shi, Zhenda; Zou, Jun; Zhang, Zhan; Xu, Zu-De; Noriega, Juan; Zhang, Benyue; Zhao, Chunyu; Ingle, Harshad; Bittinger, Kyle; Mattei, Lisa M.; Pruijssers, Andrea J.; Plemper, Richard K.; Nice, Timothy J.; Baldridge, Megan T.; Dermody, Terence S.; Chassaing, Benoît; Gewirtz, Andrew T.

doi:10.1016/j.cell.2019.09.028

Cited by 113 publications

(106 citation statements)

References 64 publications

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“…Bacteria and their products can also detrimentally impact virion stability and infectivity. Segmented filamentous bacteria protect mice from rotavirus infection independent of interferon, IL-17, and IL-22 [26]. Fecal transfer from mice bearing segmented filamentous bacteria also protects susceptible animals from infection with IAV, vesicular stomatitis virus, and reovirus.…”

Section: Bacteria and Bacterial Components Influence Virion Stabilitymentioning

confidence: 99%

Virus interactions with bacteria: Partners in the infectious dance

Neu

Mainou

2020

PLoS Pathog

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The outcome of viral infection depends on the interplay between host factors and the environment. Host factors, like the expression of viral receptors, convey permissiveness to infection, define tropism, regulate antiviral immune responses, determine viral clearance, and spread. The host microbiota, the constellation of microbes inhabiting an organism, also plays a key role in the outcome of infection. Microbes and microbial products can directly interact with viral particles. Our understanding of how the microbiota impacts virus infection is largely limited to the bacterial component of the microbiota. Although bacteria do not support eukaryotic virus infection, they can promote viral fitness by enhancing virion stability, promoting infection of eukaryotic cells, and increasing coinfection rates. Virus binding of bacteria can also impact bacterial biology, including bacterial adherence to eukaryotic cells. These interactions can also indirectly affect the host response to viral infection. In this Pearl, we focus on how direct and indirect interactions between viruses and bacteria impact viral biology and touch on recent findings that illustrate how bacterial biology can also be impacted by interactions with eukaryotic viruses (Fig 1).

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Section: Bacteria and Bacterial Components Influence Virion Stabilitymentioning

confidence: 99%

Virus interactions with bacteria: Partners in the infectious dance

Neu

Mainou

2020

PLoS Pathog

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“…Relying on public RNA-seq data (GSE71734), we explored the expression change of coronavirus receptors in the presence of probiotics [17]. Segmented Filamentous Bacteria (SFB) is a probiotic widely investigated in mouse and proved even prevent and cure rotavirus infection [18]. However, we found that SFB increased expression of coronavirus receptors Ace2 and Anepep rather than decreased (Fig.…”

Section: The Expression Of Coronaviruses Receptors In the Presence Ofmentioning

confidence: 99%

The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics

Zhan¹,

Wang²,

Wu³

2020

Preprint

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Understanding how the coronaviruses invade our body is an essential point, and the expression profile of coronaviruses receptor may help us to find where the coronavirus infects our body. We found that the coronavirus receptors, including angiotensin-converting enzyme 2 (ACE2) for SARS-CoV and SARS-Cov-2, are digestion-related enzymes in human enterocytes. Coronaviruses are continually altering the binding receptor and binding modes during their evolution, but the potential target cell in the small intestine is constant when in the lung is inconstant. Enterocytes may act as a conserved cell reservoir for coronaviruses, which may be partially explained by the Red Queen hypothesis. We also found that coronaviruses receptors could be elevated in the presence of both invasive bacteria and their counterpart, probiotics. We demonstrated here that enterocytes act as a conserved cell reservoir for coronaviruses during their evolutions, which should not be ignored in the investigation of coronavirus diagnosis and treatment strategies.

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“…However, their potent triggering of T helper 17 (T H 17) cell differentiation is perhaps their most eye-catching attribute 18 in terms of immunomodulation. Interestingly, very recent experiments applying immunodeficient mice, demonstrated the ability of SFB to also confer protection against rotavirus infection independent of immune cells 19 .…”

Section: Introductionmentioning

confidence: 99%

Genome Sequence of Segmented Filamentous Bacteria Present in the Human Intestine

Jonsson

Hugerth

Sundh

et al. 2019

Preprint

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Segmented filamentous bacteria (SFB) colonize the small intestine of a variety of animals in a host-specific manner. SFB are physically attached to the host's intestinal epithelium and affect several functions related to the immune system, among them IgA production and T-cell maturation. Until now, no human-specific SFB genome had been described. Here, we report the metagenomic reconstruction of an SFB genome from a human ileostomy sample. Phylogenomic analysis clusters the genome with the SFB genomes from mouse, rat and turkey, but the genome is genetically distinct, displaying 65 -71% average amino acid identity to the other genomes, and is tentatively unique for the human small intestine. By screening human faecal metagenomic datasets, we identified individuals carrying sequences identical to the new SFBgenome. We thus conclude that a unique SFB variant exists in humans and we foresee a renewed interest in the elucidation of SFB functionality in this environment.

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Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

Abstract: Highlights d Some mouse colonies developed spontaneous resistance to rotavirus (RV) infection d Fecal microbial transplantation transfers RV resistance d Protection against RV was mediated by segmented filamentous bacteria (SFB) d SFB impeded RV by increasing epithelial cell turnover

Cited by 113 publications

References 64 publications

Virus interactions with bacteria: Partners in the infectious dance

Virus interactions with bacteria: Partners in the infectious dance

The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics

Genome Sequence of Segmented Filamentous Bacteria Present in the Human Intestine

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