Segmentation of the Cingulum Bundle in the Human Brain: A New Perspective Based on DSI Tractography and Fiber Dissection Study

Wu, Yupeng; Sun, Dongxue; Wang, Yong; Wang, Yibao; Ou, Shaowu

doi:10.3389/fnana.2016.00084

Cited by 130 publications

(110 citation statements)

References 74 publications

(106 reference statements)

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“…Moreover, we did not parse the nominal pathways into their respective subdivisions. For example, we neither distinguished between subgenual and retrosplenial subdivisions of CB (Jones et al, ; Wu et al, ), nor the three subdivisions of the UF (Bhatia et al, ). Future attempts at identifying subdivisions within pathways may help improve the specificity of tractographic analysis and help delineate which gray matter areas are directly affected by DBS.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation

Howell

Choi

Gunalan

et al. 2018

Human Brain Mapping

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Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from patient-specific computational models. This connectomic-based biophysical modeling strategy has proven successful in improving the clinical response to SCC DBS therapy, but the DBS models used to date have been relatively simplistic, limiting the precision of the pathway activation estimates. Therefore, we used the most detailed patient-specific foundation for DBS modeling currently available (i.e., field-cable modeling) to evaluate SCC DBS in our most recent cohort of six subjects, all of which were responders to the therapy. We quantified activation of four major pathways in the SCC region: forceps minor (FM), cingulum bundle (CB), uncinate fasciculus (UF), and subcortical connections between the frontal pole and the thalamus or ventral striatum (FP). We then used the percentage of activated axons in each pathway as regressors in a linear model to predict the time it took patients to reach a stable response, or TSR. Our analysis suggests that stimulation of the left and right CBs, as well as FM are the most likely therapeutic targets for SCC DBS. In addition, the right CB alone predicted 84% of the variation in the TSR, and the correlation was positive, suggesting that activation of the right CB beyond a critical percentage may actually protract the recovery process.

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Section: Discussionmentioning

confidence: 99%

Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation

Howell

Choi

Gunalan

et al. 2018

Human Brain Mapping

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“…The CAB is connected with brain regions underlying both higher-order cognitive functioning and emotion processing and implicated in neurodegeneration pathology [41]. Moreover, associations have been reported between CAB integrity and functioning in episodic memory, decision-making, and executive control [42,43]. The CAB has also been shown to directly connect the posterior cingulate cortex and the subiculum of the hippocampus [44], both of which are critical nodes in the default mode network shown to be altered in PTSD [1,45].…”

Section: Discussionmentioning

confidence: 99%

Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

Averill¹,

Averill²,

Wrocklage³

et al. 2018

Complex Psychiatry

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Purpose of the Study: Prior studies showed posttraumatic stress disorder (PTSD)-related alterations in white matter integrity, but most of these studies have used region-based approaches. We address this limitation by investigating the relationship between PTSD severity and fractional anisotropy (FA) using a tract-based approach. Procedures: Structural and diffusion magnetic resonance imaging were acquired from 67 combat-exposed US Veterans and processed using FSL/FreeSurfer TRActs Constrained by UnderLying Anatomy. Partial correlations were conducted between PTSD severity and FA of the cingulum and uncinate fasciculi covarying for age, sex, and head motion. Results: Only FA of the left cingulum angular bundle (CAB) was positively correlated with PTSD symptom severity (r = 0.433, p = 0.001, df = 57) and remained significant after Bonferroni correction. Conclusions: This finding may imply greater organization of the CAB with increasing PTSD severity. The CAB connects directly to the cingulate cortex and the hippocampal subiculum, critical nodes of the default mode network, as well as being implicated in neurodegeneration pathology, decision-making, and executive functions, which may help explain previously shown alterations in this network in PTSD. Message of the Paper: Further study of white matter tract integrity in PTSD is warranted, particularly to investigate whether the CAB connections with both higher-order cognitive functioning and emotion processing regions contribute to the pathophysiology and comorbidity of PTSD.

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“…Previous studies have reported reduced ACC activation [Kana et al, ] and aberrant fronto‐ACC FC in ASD during inhibitory control tasks [Kana et al, ; Padmanabhan et al, ; Solomon et al, ]. Ikuta et al [] reported reduced fractional anisotropy in the cingulum bundle, which connects frontal, temporal and parietal regions [Wu et al, 2016]. Taken together, this suggests that IFJ‐dACC FC may be a locus of dysregulation in children with ASD and should be a focus of future studies of inhibitory control in children with the disorder.…”

Section: Discussionmentioning

confidence: 86%

Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder

et al. 2018

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Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ‐SPL and rIFJ‐IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ‐dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Autism Research 2018, 11: 1468–1478. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent‐reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder.

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Segmentation of the Cingulum Bundle in the Human Brain: A New Perspective Based on DSI Tractography and Fiber Dissection Study

Cited by 130 publications

References 74 publications

Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation

Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation

Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder

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