Segmentation of Hematopoietic Sites of Human Skeleton for Calculations of Dose to Active Marrow Exposed to Bone-Seeking Radionuclides

Sharagin, P.A.; Shishkina, E.A.; Толстых, Е. И.; Volchkova, A Yu; Smith, Michael A.

doi:10.21175/radproc.2018.33

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…The SPSD approach simulates the individual variability of macro and microarchitecture of bone segments using the random generator of computational phantoms ‘Trabecula’ [ 25 ]. Basic segment phantoms of adult man [ 27 ] were supplemented with a set of additional random models to be used in Monte Carlo simulation of electron transport. The selection of micro and macro parameter values was performed with lognormal and normal approaches respectively, using a 90% confidence interval (i.e., 10% of the values associated with the tails of the distributions were considered as outliers).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, only hematopoietic sites were considered. Each of the complex-shaped bone sites under consideration [ 1 ] is subdivided into a set of simple-shaped segments with mostly homogeneous and isotropic microstructure [ 27 ]. Such a segment could be described by simple geometry ( Table 1 ).…”

Section: General Spsd Approachesmentioning

confidence: 99%

“…A truncated cone is a particular case of deformed cylinder. 21 [ [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [33] ] Triangular pyramid Pyramids are only used to describe a segment of pelvic ischium acetabulum and a segment of sacral ala 2% [0–3] Ellipsoid Typical of talus and calcaneus of both hand and foot; considered as hematopoietic for newborn only <0.6 [0–3] Tube A figure bounded by the two nested cylinders; typical of pelvic acetabulum only. 1 [0–2]

Fig.…”

Section: General Spsd Approachesmentioning

confidence: 99%

“…The outer boundaries of phantoms depend on segment-specific linear dimensions. Each of the parameters is segment-specific and derived from literature [ 24 , 27 ].…”

Section: General Spsd Approachesmentioning

confidence: 99%

See 3 more Smart Citations

Uncertainty of stochastic parametric approach to bone marrow dosimetry of 89,90Sr

Shishkina,

Sharagin,

Tolstykh

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Section: General Spsd Approachesmentioning

confidence: 99%

Fig.…”

Section: General Spsd Approachesmentioning

confidence: 99%

“…The outer boundaries of phantoms depend on segment-specific linear dimensions. Each of the parameters is segment-specific and derived from literature [ 24 , 27 ].…”

Section: General Spsd Approachesmentioning

confidence: 99%

See 2 more Smart Citations

Uncertainty of stochastic parametric approach to bone marrow dosimetry of 89,90Sr

Shishkina,

Sharagin,

Tolstykh

et al. 2024

Heliyon

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“…The parametric approach allows creating a set of random models reflecting the individual variability of bone micro and macro dimensions. Computational phantoms are generated by software «Trabecula» (Shishkina et al 2020) as figures of simple geometric shape (Sharagin et al 2018). Phantoms consist of a spongiosa, where rod-like bone trabeculae penetrate the bone marrow, and a cortical bone layer covering it.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Radiat Environ Biophys

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Studies of radiobiological effects in murine rodents exposed to internal radiation in the wild or in laboratory experiments require a dosimetric support. The main problem of bone marrow (BM) dosimetry for boneseeking β-emitters is dosimetric modeling due to the fact that the bone is a heterogeneous structure with complex microarchitecture. To date, there are several approaches to calculating the absorbed dose in BM, which mostly use rough geometric approximations. Recently, in the framework of studies of people exposed to 90 Sr in the Urals, a new approach (SPSD) has been developed. The aim of current study was to pilot test the possibility of extension of the SPSD-approach elaborated for humans to mice. The computational phantoms of femur bones of laboratory animals (C57BL/6, C57BL/6J, BALB/c, BALB/cJ) aged 5-8 weeks (growing) and >8 weeks (adults) were created. The dose factors to convert the 89,90 Sr activity concentrations in a bone tissue into units of the dose rate absorbed in the bone marrow were estimated as follows: DFSr-90(BMTBV+CBV) is equal to 1.75±0.42 and 2.57±0.93 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively; DFSr-89(BMTBV+CBV) is equal to 1.08±0.27 and 1.66±0.67 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively. These results are about 2.5 times lower than skeleton-average DF, calculated assuming the homogenous bone, where source and target coincide. The study demonstrates the possibility of application of the SPSD-approach elaborated for humans to non-human mammals.

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Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

et al. 2021

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The objective of this study is to develop a skeleton model for assessing active marrow dose from bone-seeking beta-emitting radionuclides. This article explains the modeling methodology which accounts for individual variability of the macro- and microstructure of bone tissue. Bone sites with active hematopoiesis are assessed by dividing them into small segments described by simple geometric shapes. Spongiosa, which fills the segments, is modeled as an isotropic three-dimensional grid (framework) of rod-like trabeculae that “run through” the bone marrow. Randomized multiple framework deformations are simulated by changing the positions of the grid nodes and the thickness of the rods. Model grid parameters are selected in accordance with the parameters of spongiosa microstructures taken from the published papers. Stochastic modeling of radiation transport in heterogeneous media simulating the distribution of bone tissue and marrow in each of the segments is performed by Monte Carlo methods. Model output for the human femur at different ages is provided as an example. The uncertainty of dosimetric characteristics associated with individual variability of bone structure was evaluated. An advantage of this methodology for the calculation of doses absorbed in the marrow from bone-seeking radionuclides is that it does not require additional studies of autopsy material. The biokinetic model results will be used in the future to calculate individual doses to members of a cohort exposed to 89,90Sr from liquid radioactive waste discharged to the Techa River by the Mayak Production Association in 1949–1956. Further study of these unique cohorts provides an opportunity to gain more in-depth knowledge about the effects of chronic radiation on the hematopoietic system. In addition, the proposed model can be used to assess the doses to active marrow under any other scenarios of 90Sr and 89Sr intake to humans.

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Segmentation of Hematopoietic Sites of Human Skeleton for Calculations of Dose to Active Marrow Exposed to Bone-Seeking Radionuclides

Cited by 10 publications

References 6 publications

Uncertainty of stochastic parametric approach to bone marrow dosimetry of 89,90Sr

Uncertainty of stochastic parametric approach to bone marrow dosimetry of 89,90Sr

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

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