Segmentation of cervical nuclei using SLIC and pairwise regional contrast

Saha, Ratna; Bajger, Mariusz

doi:10.1109/embc.2018.8513021

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…Saha et al [15,16] used fuzzy c-means clustering constrained by a Circular Shape Function (CSF) to detect a nucleus. Later on, Saha et al [17] also proposed a method of segmenting cervical nuclei by merging the oversegmented SLIC superpixel regions based on pairwise regional contrast and image gradient contour evaluations. Their more recent work [18] proposes to segment nuclei by merging superpixels generated by the statistical region merging (SRM) algorithm using pairwise regional contrasts and gradient boundaries.…”

Section: Introductionmentioning

confidence: 99%

A contour property based approach to segment nuclei in cervical cytology images

et al. 2021

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Background Segmentation of nuclei in cervical cytology pap smear images is a crucial stage in automated cervical cancer screening. The task itself is challenging due to the presence of cervical cells with spurious edges, overlapping cells, neutrophils, and artifacts. Methods After the initial preprocessing steps of adaptive thresholding, in our approach, the image passes through a convolution filter to filter out some noise. Then, contours from the resultant image are filtered by their distinctive contour properties followed by a nucleus size recovery procedure based on contour average intensity value. Results We evaluate our method on a public (benchmark) dataset collected from ISBI and also a private real dataset. The results show that our algorithm outperforms other state-of-the-art methods in nucleus segmentation on the ISBI dataset with a precision of 0.978 and recall of 0.933. A promising precision of 0.770 and a formidable recall of 0.886 on the private real dataset indicate that our algorithm can effectively detect and segment nuclei on real cervical cytology images. Tuning various parameters, the precision could be increased to as high as 0.949 with an acceptable decrease of recall to 0.759. Our method also managed an Aggregated Jaccard Index of 0.681 outperforming other state-of-the-art methods on the real dataset. Conclusion We have proposed a contour property-based approach for segmentation of nuclei. Our algorithm has several tunable parameters and is flexible enough to adapt to real practical scenarios and requirements.

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Section: Introductionmentioning

confidence: 99%

A contour property based approach to segment nuclei in cervical cytology images

et al. 2021

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“…Fatigue-and experience-induced failures always occur and result in low operation success rates and large damage, thus degrading the performance of intracellular manipulation [22,23]. Generally, intracellular objects are fragile [24,25] and usually have irregular shapes [26,27], distribution [28,29], and small sizes [30,31]. For example, mitochondria in mammalian animals are usually less than 2 µm and randomly distribute among the cytoplasm [32].…”

Section: Introductionmentioning

confidence: 99%

Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

et al. 2020

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Intracellular micromanipulation assisted by robotic systems has valuable applications in biomedical research, such as genetic diagnosis and genome-editing tasks. However, current studies suffer from a low success rate and a large operation damage because of insufficient information on the operation information of targeted specimens. The complexity of the intracellular environment causes difficulties in visualizing manipulation tools and specimens. This review summarizes and analyzes the current development of advanced biological imaging sampling and computational processing methods in intracellular micromanipulation applications. It also discusses the related limitations and future extension, providing an important reference about this field.

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Superpixel/voxel medical image segmentation algorithm based on the regional interlinked value

Fang

Wang

2021

Pattern Anal Applic

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Segmentation of cervical nuclei using SLIC and pairwise regional contrast

Cited by 7 publications

References 14 publications

A contour property based approach to segment nuclei in cervical cytology images

A contour property based approach to segment nuclei in cervical cytology images

Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

Superpixel/voxel medical image segmentation algorithm based on the regional interlinked value

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