Segmentary effects on the renal proximal tubule due to hexachloro‐1,3‐butadiene in rats: biomarkers related to gender

Trevisan, Andrea; Cristofori, Patrizia; Beggio, Marianna; Venturini, Matteo Borella; Marco, Livio Di; Zanetti, Elena

doi:10.1002/jat.1004

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…36 Recently, Trevisan et al found that, unlike liver, kidney GSH content significantly increased 24 and 48 h after treatment with HCBD in male rats but not in female rats or in renal cortical slices, in vitro. 3 PSO is a rich source of conjugated fatty acids of which punicic acid is the most common. 37,38 Polyphenolic compounds are also present in the seed oil of the pomegranate.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys

et al. 2010

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In this study, the effect of pomegranate seed oil (PSO) on HCBD-induced nephrotoxicity was investigated in adult male rats. Animals were divided into five groups. Group 1 was treated with corn oil (1 mL/kg, i.p.). Group 2 received a single dose of HCBD (50 mg/kg, i.p.). Groups 3-5 were treated with PSO (0.16, 0.32, and 0.64 mg/kg, i.p., respectively) 1 h before HCBD (50 mg/kg, i.p.) injection. A significant elevation of serum creatinine and urea (p < 0.001) levels as well as urine glucose and protein (p < 0.001) concentrations (as markers of acute renal failure) was observed 24 h after administration of HCBD as compared to control group. HCBD also caused a significant decrease in total thiol content (p < 0.001) and a significant increase in thiobarbituric acid reactive species (TBARS, as an index of lipid peroxidation) levels (p < 0.001) in kidney homogenate samples. PSO pretreatment resulted in a significant and dose-dependent decrease in serum creatinine (p < 0.001) and urea levels (p < 0.001) as well as urine glucose (p < 0.001) and protein concentrations (p < 0.001) when compared with HCBD treated alone. PSO also significantly reversed the HCBD-induced depletion in total thiol content (p < 0.001) and elevation in TBARS (p < 0.001) in kidney homogenate samples. The results of this study showed that PSO clearly attenuated HCBD-induced nephrotoxicity, but explanation and mechanism of this protection need further explorations.

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Section: Discussionmentioning

confidence: 99%

“…The solvent is also detected in aquatic organisms, birds, and mammals. 3 HCBD has deleterious health effects due to its toxicity and carcinogenicity. [4][5][6][7] HCBD is a potent nephrotoxin in rodents.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys

et al. 2010

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“…However, cyclacillin, which is a substrate of Pept1/PEPT1, was nephrotoxic in rats but not in monkeys, dogs, and humans; Pept1 is a brush-border transporter along the rat proximal tubule S1 and S2 segment, which may be expressed in higher abundance in M rats (see later) and may reabsorb the filtered compound to high, toxic levels [132,261,262]. Regarding nephrotoxicity of hexachlorobutadiene in rats, in one report, the damage in proximal tubules was stronger in M [20], whereas in another report, F were more sensitive [260]. The sensitivity of proximal tubules to toxic effects of acetaminophen, a drug that is secreted in proximal tubules via several Oats/OATs (reviewed in [39]), was much stronger in F, and this difference is lost in old animals, possibly due to age-dependent downregulation of the transporter [253].…”

Section: Gender Differences In Nephrotoxicitymentioning

confidence: 92%

Gender differences in kidney function

Sabolić

Asif

Budach

et al. 2007

Pflugers Arch - Eur J Physiol

202

165

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Sex hormones influence the development of female (F) and male (M) specific traits and primarily affect the structure and function of gender-specific organs. Recent studies also indicated their important roles in regulating structure and/or function of nearly every tissue and organ in the mammalian body, including the kidneys, causing gender differences in a variety of characteristics. Clinical observations in humans and studies in experimental animals in vivo and in models in vitro have shown that renal structure and functions under various physiological, pharmacological, and toxicological conditions are different in M and F, and that these differences may be related to the sex-hormone-regulated expression and action of transporters in the apical and basolateral membrane of nephron epithelial cells. In this review we have collected published data on gender differences in renal functions, transporters and other related parameters, and present our own microarray data on messenger RNA expression for various transporters in the kidney cortex of M and F rats. With these data we would like to emphasize the importance of sex hormones in regulation of a variety of renal transport functions and to initiate further studies of gender-related differences in kidney structure and functions, which would enable us to better understand occurrence and development of various renal diseases, pharmacotherapy, and drug-induced nephrotoxicity in humans and animals.

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“…The studies on sex-related nephrotoxicity of HCBD did not lead to unequivocal conclusions. Birner et al [43] found that HCBD-induced renal effects are more severe in male rats than in females in accordance with data on sex-specific sulfoxide metabolite formation, whereas other authors found that female rats were more sensitive to HCB [137][138][139][140] about four times than male rats [139]. These findings are probably in relation to differences in hepatic and renal enzymes responsible for the detoxification and/or activation of HCBD; in particular, female rat kidney shows marked dose-related decrease in nonprotein sulfhydryl content [137].…”

Section: Hexachloro-1:3-butadienementioning

confidence: 59%