Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu's arteritis

Dourmishev, Assen L.; Serafimova, Dimitrina; Vassileva, Snejina; Dourmishev, Lyubomir; Schwartz, Robert A.

doi:10.1111/j.1742-4801.2005.00103.x

Cited by 16 publications

(8 citation statements)

References 32 publications

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“…Cutaneous features have been observed in 2.8–28% patients depending on series and race. Patients with cutaneous features seem to be most frequent in Japan ( 78 ). Skin involvement includes: livedo reticularis, purpura, erythema nodosum, subcutaneous edema, urticaria, digital gangrena, and ulcers.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Takayasu Arteritis

2018

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Takayasu arteritis is an idiopathic granulomatous vasculitis of the aorta and its main branches and it constitutes one of the more common vasculitides in children. Inflammation and intimal proliferation lead to wall thickening, stenotic or occlusive lesions, and thrombosis, while destruction of the elastica and muscularis layers originates aneurysms and dissection. Carotid artery tenderness, claudication, ocular disturbances, central nervous system abnormalities, and weakening of pulses are the most frequent clinical features. The diagnosis is usually confirmed by the observation of large vessel wall abnormalities: stenosis, aneurysms, occlusion, and evidence of increased collateral circulation in angiography, MRA or CTA imaging. The purpose of this revision is to address the current knowledge on pathogenesis, investigations, classification, outcome measures and management, and to emphasize the need for timely diagnosis, effective therapeutic intervention, and close monitoring of this severe condition.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Takayasu Arteritis

2018

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“…12 Furthermore, other vasculitides require distinction, including microscopic polyangiitis (MPA), Wegener's granulomatosis, Churg-Strauss syndrome, erythema induratum, and urticarial vasculitis ( Table 1). [48][49][50] Microscopic polyangiitis typically affects small vessels including capillaries, venules, or arterioles, especially in the kidneys and lungs. Wegener's granulomatosis and Churg-Strauss syndrome also affect small-to medium-sized vessels; however, pulmonary involvement, granulamatous inflammation, and serum ANCA positivity are common to both.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cutaneous polyarteritis nodosa: a comprehensive review

2010

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Cutaneous polyarteritis nodosa is a rare form of vasculitis relating to small-to-medium-sized arteries. Its etiology is unknown. Clinical manifestations include tender subcutaneous nodules, livedo reticularis, cutaneous ulcers and necrosis. Although it is distinct from systemic polyarteritris nodosa in that it lacks significant internal organ involvement, extra-cutaneous manifestations may be evident. Commonly encountered symptoms include fever, malaise, myalgias, arthralgias, and paresthesias. Exclusion of systemic polyarteritis nodosa is essential in diagnosis. The clinical course is chronic with remissions, relapses, and a favorable prognosis. Mild cases may resolve with nonsteroidal anti-inflammatory drugs. If more severe, treatment with systemic corticosteroids generally achieves adequate response; however, adjunctive therapy is often necessary to allow reduction in steroid dosage.

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“…7 In majority of patients, TA precedes the manifestation of cutaneous vasculitic ulceration. 8 We have reviewed reports of seven such patients diagnosed with paediatric PG-like vasculitic ulceration-associated TA (Table S2), in addition to the three case reports given in the previous section.…”

Section: Discussionmentioning

confidence: 99%

“…Lesions considered to be associated with TA include cutaneous vasculitic ulceration, erythema nodosum, granulomatous vasculitis and erythema induratum 7 . In majority of patients, TA precedes the manifestation of cutaneous vasculitic ulceration 8 . We have reviewed reports of seven such patients diagnosed with paediatric PG‐like vasculitic ulceration‐associated TA (Table S2), in addition to the three case reports given in the previous section.…”

Section: Discussionmentioning

confidence: 99%