SEER Study of Ablation Versus Partial Nephrectomy in cT1A Renal Cell Carcinoma

Abstract

Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.

Society of Interventional Radiology Quality Improvement Standards on Percutaneous Ablation in Renal Cell Carcinoma

“…Conversely, some studies reported clinical outcomes to 5 years. Overall survival after IGTA of T1a RCC ranges from 74% to 97.8% with a weighted mean of 79% (15,17,18,22,23,68,69,77). The threshold for OS of IGTA for T1a RCC is 64%.…”

Assessment of local tumor ablation and non-interventional management versus partial nephrectomy in T1a renal cell carcinoma

“…Data regarding LTA versus nephrectomy originating from 7 institutional studies (from 1998 to 2012) formed the basis of a recent meta-analysis 7 , which showed a 3.4-fold increase of cancer specific mortality (CSM) when LTA was performed instead of partial (PN) or radical nephrectomy (RN). Conversely, of five population based studies [8][9][10][11][12] , only one 9 showed worse CSM for LTA relative to PN. However, their historic nature represents a limitation; the most recent included patients diagnosed from 2004 to 2013 12 .…”

“…Conversely, of five population based studies [8][9][10][11][12] , only one 9 showed worse CSM for LTA relative to PN. However, their historic nature represents a limitation; the most recent included patients diagnosed from 2004 to 2013 12 . Moreover, with the exception of SEER-Medicare studies 10,11 that exclusively focused on patients older than 65 years, no stratification was performed according to age.…”

Society of Interventional Radiology Position Statement on the Role of Percutaneous Ablation in Renal Cell Carcinoma

“…Three recent studies used the National Cancer Institute's SEER cancer registry to ascertain survival outcomes of ablation compared to surgical techniques for small renal masses (18)(19)(20).…”

“…Zhou et al (18) used the SEER database in a study comparing ablation (either cryoablation or thermal ablation) to PN in patients from 2004 to 2013. In the propensity-matched cohort, the PN group had significantly increased overall 5-year survival compared to the ablation group (91.0% vs 86.3%; hazard ratio [HR] ¼ 1.442; 95% confidence interval [CI], 1.005-2.068; P ¼ .0457).…”