Seemingly paradoxical seasonal influences on vitamin D status in nursing-home elderly people from a Mediterranean area

Pérez‐Llamas, Francisca; López-Contreras, María José; Blanco, Marı́a José; López-Azorín, Fernando; Zamora, Salvador; Moreiras, O

doi:10.1016/j.nut.2008.01.006

Cited by 39 publications

(36 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This state of calciferol insufficiency is replicated in Spain, with results which we show in table 1 [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . The interlaboratory variation in the different methodologies used makes a rigorous comparison difficult, but the table illustrates clearly that, in spite of a theoretical climatological ease of vitamin D synthesis in Spain, the levels are similar to, or even lower than those reported for central Europe or Scandinavia, as has been described in earlier works 39 .…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 54%

Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

View full text Add to dashboard Cite

Vitamin D 3 (colecalciferol) is formed from its precursor 7-dehydrocholesterol in the skin by ultraviolet irradiation. In the liver the vitamin D 3 is hydroxylated to form 25-hydroxyvitamin D 3 , which is metabolised to its active metabolite 1,25-dihydroxyvitamin D 3 preferentially in the kidney. Vitamin D 3 may also be provided in the diet, which is a significant source of supply only in the case of insufficient exposure to sunlight. Blue fish naturally contains large quantities of vitamin D 3 , while other foods contain significant quantities of vitamin D only after being fortified. For fortification, in many countries vitamin D 2 is used (ergocalciferol) obtained from vegetable sources 1 . The presence of the enzyme CYP27B1, which drives the synthesis of dihydroxyvitamin D from its principal substrate, 25-hydroxyvitamin D, and the vitamin D receptor (VDR), distributed almost universally in the cells and tissues of the organism, confers on vitamin D (although it would be increasingly more correct to say the endocrine system of vitamin D) a broad role in health. This is not only in the regulation of calcium and bone metabolism but also in relation to the cardiovascular system, innate or acquired immunomodulation, the regulation of cell growth, etc., such that around 3% of the human genome is regulated by the hormone 1,25(OH) 2 vitamin D 3 1-3 . It is therefore not surprising that basic scientific and clinical interest in vitamin D 4 , as well as interest in the non-specialist press and in the general population 5 , has increased almost exponentially in the last decade. 25-hydroxyvitamin D, marker for the status of vitamin D in the bodyFor some years there has been universal consensus that the measurement of the levels of the metabolite 25-hydroxyvitamin D in the blood is the marker for the status of vitamin D in the body, including the endogenous synthesis due to exposure to sunlight, dietary consumption in foods, supplemented or not, and pharmacological treatments 1,2

show abstract

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 54%

Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

View full text Add to dashboard Cite

show abstract

“…Several studies have been conducted in Spain on the vitamin D nutritional situation, especially during the 1990s. Most of these studies coincided concerning the presence of vitamin D deficiency, but the prevalence figures for the deficit varied, probably because most were carried out with opportune or institutionalized samples, and generally involved a low number of persons (Gó mez-Alonso et al Vaquero et al, 2004;Gonzalez Solanellas et al, 2008;Mata-Granados et al, 2008;Pérez-Llamas et al, 2008;Calatayud et al, 2009). In other countries in Europe, the percentages of deficiency and insufficiency vary (Lips, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The mean levels of 25-hydroxyvitamin D in middle aged people range from 14 to 25.9 ng/ml, with 26-85.1% of persons having values o20 ng/ml (Gonzalez Solanellas et al, 2008;MataGranados et al, 2008;Calatayud et al, 2009). In persons aged X60 years, the mean 25-hydroxyvitamin D concentration is even lower: 6.95-17 ng/ml, with 46.4-85% having values o20 ng/ml (Gó mez- Alonso et al, 2003;Vaquero et al, 2004;Niño Martín and Pérez Castrilló n, 2008;Pérez-Llamas et al, 2008;Rodríguez Sangrador et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in Spain: a population-based cohort study

et al. 2010

View full text Add to dashboard Cite

Background: Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants. Objective: To study the population concentrations of vitamin D in a representative sample of the Spanish population. Subjects/Methods: The study involved two cohorts from Spain, the Asturias study and the Pizarra study, which are two prospective, population-based studies involving 2260 participants. In 1262 subjects (age: 20-83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus and creatinine.

show abstract

“…Several international studies have shown that vitamin D deficiency is highly prevalent in the elderly (23,30,31,32,33,34,35). A few relatively small Scandinavian studies found that vitamin D deficiency was common, especially in elderly people living in homes for the aged (30,31).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality

Samefors

Östgren

Mölstad

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Institutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency. In addition to osteoporosis-related disorders, vitamin D deficiency may influence several medical conditions conferring an increased mortality risk. The aim of this study was to explore the prevalence of vitamin D deficiency and its association with mortality. Design: The Study of Health and Drugs in the Elderly (SHADES) is a prospective cohort study among elderly people (O65 years) in 11 nursing homes in Sweden. Methods: We analysed the levels of 25-hydroxyvitamin D 3 (25(OH)D 3 ) at baseline. Vital status of the subjects was ascertained and hazard ratios (HRs) for mortality according to 25(OH)D 3 quartiles were calculated. Results: We examined 333 study participants with a mean follow-up of 3 years. A total of 147 (44%) patients died within this period. Compared with the subjects in Q4 (25(OH)D 3 O48 nmol/l), HR (with 95% CI) for mortality was 2.02 (1.31-3.12) in Q1 (25(OH)D 3 !29 nmol/l) (P!0.05); 2.03 (1.32-3.14) in Q2 (25(OH)D 3 30-37 nmol/l) (P!0.05) and 1.6 (1.03-2.48) in Q3 (25(OH) D 3 38-47 nmol/l) (P!0.05). The mean 25(OH)D 3 concentration was 40.2 nmol/l (S.D. 16.0) and 80% had 25(OH)D 3 below 50 nmol/l. The vitamin D levels decreased from baseline to the second and third measurements. Conclusions: Vitamin D deficiency was highly prevalent and associated with increased mortality among the elderly in Swedish nursing homes. Strategies are needed to prevent, and maybe treat, vitamin D deficiency in the elderly in nursing homes and the benefit of vitamin D supplementation should be evaluated in randomised clinical trials.

show abstract

Seemingly paradoxical seasonal influences on vitamin D status in nursing-home elderly people from a Mediterranean area

Cited by 39 publications

References 39 publications

Deficiencia de vitamina D en España: ¿realidad o mito?

Deficiencia de vitamina D en España: ¿realidad o mito?

Vitamin D deficiency in Spain: a population-based cohort study

Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality

Contact Info

Product

Resources

About