Seemingly healthy skin in atopic dermatitis: observations with the use of high‐frequency ultrasonography, preliminary study

Dańczak‐Pazdrowska, Aleksandra; Polańska, Adriana; Silny, Wojciech; Sadowska, Anna; Osmola‐Mańkowska, Agnieszka; Czarnecka‐Operacz, Magdalena; Żaba, Ryszard; Jenerowicz, Dorota

doi:10.1111/j.1600-0846.2011.00548.x

Cited by 28 publications

(40 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 In patients with atopic dermatitis, even skin that appears normal has a compromised epidermal barrier and is immunologically abnormal, emphasizing the need to treat the patient as a whole rather than just individual lesions. 20 Diagnosis is generally clinical, and the Eczema Area and Severity Index (EASI) and the SCORAD systems are 2 systems that appear to be the most reliable and user-friendly and share the advantage that they are most commonly used in contemporary clinical trials. Both systems generate quantifiable data that are amenable to analysis.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Bathing in the Management of Atopic Dermatitis

Koutroulis

Petrova

Kratimenos

et al. 2014

Clin Pediatr (Phila)

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of Bathing in the Management of Atopic Dermatitis

Koutroulis

Petrova

Kratimenos

et al. 2014

Clin Pediatr (Phila)

View full text Add to dashboard Cite

show abstract

“…One of the newly introduced methods in the assessment of AD is HF-USG, which is easily reproducible and allows clinicians to visualize pathologic changes of the skin in vivo [19, 28, 29]. Different disorders, depending on their etiology, may significantly influence the ultrasound image by changing its echogenicity [30].…”

Section: Discussionmentioning

confidence: 99%

“…A typical gain curve was 25-70 dB. The velocity of ultrasound in the skin was set at 1.580 m/s [19, 21]. …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Nonlesional skin in atopic dermatitis is seemingly healthy skin - observations using noninvasive methods.

Polańska¹,

Dańczak‐Pazdrowska²,

Silny³

et al. 2013

Videosurgery and Other Miniinvasive Techniques

Self Cite

View full text Add to dashboard Cite

IntroductionAtopic dermatitis (AD) is a chronic and relapsing skin disorder, which is characterized by abnormal skin barrier function within the entire skin surface. Several noninvasive bioengineering methods have been commonly used to quantify disease severity. High-frequency ultrasonography (HF-USG) is an important contribution to this field.AimTo evaluate noninvolved skin during the external treatment in relation to involved regions in patients with AD skin using noninvasive methods.Material and methodsTransepidermal water loss (TEWL), capacitance and erythema assessment and HF-USG were performed in 55 AD patients within 2 regions (involved and uninvolved skin) before and after therapy. The clinical severity of the disease process was based on the eczema area and severity index (EASI) score. A control group consisting of 15 subjects was also included.ResultsOn the basis of 4 bioengineering methods our study revealed that uninvolved skin in AD presents subclinical disturbances and significantly changes during therapy. The HF-USG detects inflammation in the upper dermis in AD patients in the form of a hypoechoic band, which may also be observed to a lesser extent within normal-appearing skin.ConclusionsNonlesional skin differs significantly from lesional skin in AD and from skin of healthy subjects. Noninvasive methods are able to measure subclinical skin disturbances within normal-appearing skin, which are not evaluated using standard clinical scores. They are objective and may facilitate communication between different research groups.

show abstract

“…Thus, there is a need for searching for bioengineering instrumental assessment, which will simplify and provide an objective evaluation of the disease process [7,[9][10][11]. In this field especially the measurement of TEWL and water content of SC (skin capacitance, corneometry) are in routine clinical usage, however evaluation of erythema and the measure of specific parameters with the use of highfrequency ultrasonography (HF-USG) may also enhance the assessment [7,[14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of selected skin barrier functions in atopic dermatitis in relation to the disease severity and pruritus

Polańska¹,

Dańczak‐Pazdrowska²,

Silny³

et al. 2012

pdia

Self Cite

View full text Add to dashboard Cite

A b s t r a c t I In nt tr ro od du uc ct ti io on n: : Atopic dermatitis (AD) is an inflammatory pruritic dermatosis, which is characterized by an impaired skin barrier function manifested as an increased transepidermal water loss (TEWL). A Ai im m: : Presentation results of instrumental evaluation of the skin barrier function in AD patients in relation to the disease severity as well as pruritus. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Fifty-five AD patients aged from 8 to 60 years were enrolled to the study. Epidermal barrier function (TEWL measurement and corneometry) as well as erythema measurement were determined in each patient within the same affected skin region, antecubital fossa. Clinical evaluation was performed using the W-AZS scoring system. R Re es su ul lt ts s: : There was a statistically significant difference in the mean TEWL values between groups of patients with different degrees of skin inflammation expressed by the W-AZS index, while no significant differences were observed in relation to the skin hydration and ertyhema measurement. There was a statistically significant correlation between the W-AZS index and TEWL as well as between the W-AZS I index and TEWL. C Co on nc cl lu us si io on ns s: : Selected parameters of the skin barrier function (TEWL, skin hydration) and the level of erythema are useful in evaluation of AD. Transepidermal water loss measurement presents a good correlation with W-AZS and with intensity of patients itching. Instrumental assessment provides us with a fast and objective evaluation of the eczema status, what seems to be very important in the era of evidence-based medicine.K Ke ey y w wo or rd ds s: : atopic dermatitis, skin barrier, transepidermal water loss.

show abstract

Seemingly healthy skin in atopic dermatitis: observations with the use of high‐frequency ultrasonography, preliminary study

Cited by 28 publications

References 16 publications

Frequency of Bathing in the Management of Atopic Dermatitis

Frequency of Bathing in the Management of Atopic Dermatitis

Nonlesional skin in atopic dermatitis is seemingly healthy skin - observations using noninvasive methods.

Evaluation of selected skin barrier functions in atopic dermatitis in relation to the disease severity and pruritus

Contact Info

Product

Resources

About