Abstract:Alternative polyadenylation (APA) represents an important mechanism for regulating isoform-specific translation efficiency, stability, and localisation. Though some progress has been made in understanding its consequences in metazoans, the role of APA in the model organism Saccharomyces cerevisiae remains a relative mystery because, despite abundant studies on the translational state of mRNA, none differentiate mRNA isoforms’ alternative 3′-end. This review discusses the implications of alternative polyadenyla… Show more
“…The collection also includes two reviews that describe recent data on two important aspects of translation regulation. The first, by Turner and Beilharz [ 4 ], deals with mechanisms of alternative polyadenylation, which generate alternative RNA isoforms and consequently affect mRNA translation and localization. Important findings on this process were uncovered in yeast due to the ease of its genetic manipulations and molecular assays.…”
Translation regulation and localized translation are essential for protein synthesis, controlling all aspects of cellular function in health and disease [...]
“…The collection also includes two reviews that describe recent data on two important aspects of translation regulation. The first, by Turner and Beilharz [ 4 ], deals with mechanisms of alternative polyadenylation, which generate alternative RNA isoforms and consequently affect mRNA translation and localization. Important findings on this process were uncovered in yeast due to the ease of its genetic manipulations and molecular assays.…”
Translation regulation and localized translation are essential for protein synthesis, controlling all aspects of cellular function in health and disease [...]
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