Seeing Is Believing. Sensing Real Progress in the Study of Human Airway Nerves

McGarvey, Lorcan

doi:10.1164/rccm.201505-0873ed

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…A longstanding view is that inflammation may induce neuronal sensitisation which may be the underlying cause for cough in diseases such as asthma [23]. However, in previous work in severe asthma, it was suggested patient reported cough morbidity (assessed by subjective cough-specific questionnaires) was not linearly related to T2 inflammation (assessed by the presence of sputum eosinophilia).…”

Section: Discussionmentioning

confidence: 97%

An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma

Holmes¹,

McGarvey²,

Birring

et al. 2022

Eur Respir J

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Rationale and objectiveThe relationship between objectively measured cough and type-2 biomarkers and other measures of asthma control and severity is poorly understood. The objective of this study was to assess the relationship between objective and subjective cough measurement tools and clinical biomarkers of asthma.MethodsPatients with severe asthma and mild/moderate asthma completed validated asthma and cough-related measurement tools (including ambulatory cough monitoring) and measurement of spirometry and T2-biomarkers (fractional exhaled nitric oxide measurement (FeNO) and peripheral blood eosinophil count (PBE)). Patients were classified according to T2-status based on T2-low (FeNO<20ppb AND PBE<150 cells·µl−1), T2-intermediate (FeNO≥20ppb OR PBE≥150 cells·µl−1) or T2-high (FeNO≥20ppb AND PBE≥150 cells·µl−1).ResultsIn total, 61 patients completed the study measurements (42 severe asthma, 19 mild/moderate asthma). Patients with severe asthma had higher rates of cough than those with mild/moderate asthma in terms of total 24-hour cough counts (geometric mean 170·3 (sd 2·7) versus 60·8 (sd 4·1), p=0·002) and cough frequency (geometric mean, 7·1 c·h−1 (sd 2·7) versus 2·5 c·h−1 (sd 4·1), p=0·002). T2-low patients with severe asthma had significantly lower 24-hour cough frequency compared to T2-intermediate and T2-high patients.ConclusionsIn patients with low biomarkers of T2 inflammation, cough frequency measurements were not elevated, suggesting that the mechanism for cough in asthma is underlying T2-eosinophilic inflammation and the logical first step for treating cough in asthma may be to achieve adequate suppression of T2 inflammation with currently available therapies.

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Section: Discussionmentioning

confidence: 97%

An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma

Holmes¹,

McGarvey²,

Birring

et al. 2022

Eur Respir J

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“…The axons of these receptors are myelinated and have high conduction velocities. Another class of airway sensory fiber is the unmyelinated bronchial or pulmonary C-fiber ( McGarvey, 2015 ). Pulmonary C-fiber endings are found in the lung parenchyma, while bronchial C-fibers are seen within the airway mucosa ( Canning and Spina, 2009 ; Su et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Schwann cells in the normal and pathological lung microenvironment

Shurin,

Wheeler,

Shurin

et al. 2024

Front. Mol. Biosci.

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The lungs are a key organ in the respiratory system. They are regulated by a complex network of nerves that control their development, structure, function, and response to various pathological stimuli. Accumulating evidence suggests the involvement of a neural mechanism in different pathophysiological conditions in the lungs and the development and progression of common respiratory diseases. Lung diseases are the chief source of death globally. For instance, lung cancer is the second most commonly diagnosed malignancy, after prostate cancer in men and breast cancer in women, and is the most lethal cancer worldwide. However, although airway nerves are accepted as a mechanistically and therapeutically important feature that demands appropriate emphasizing in the context of many respiratory diseases, significantly less is known about the role of the neuroglial cells in lung physiology and pathophysiology, including lung cancer. New data have uncovered some cellular and molecular mechanisms of how Schwann cells, as fundamental components of the peripheral nervous system, may regulate lung cancer cells’ survival, spreading, and invasiveness in vitro and in vivo. Schwann cells control the formation and maintenance of the lung cancer microenvironment and support metastasis formation. It was also reported that the number of lung cancer-associated Schwann cells correlates with patients’ survival. Different factors secreted by Schwann cells, including microRNA, are known to sharpen the lung cancer environment by regulating the tumor-neuro-immune axis. Further clinical and experimental studies are required to elucidate the detailed role of Schwann cells in creating and maintaining pulmonary tumor-neuro-immune axis, which will advance our understanding of the pathogenesis of lung cancer and may inform therapeutic hypotheses aiming neoplasms and metastases in the lung.

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