Seeds of Buchholzia coriacea in Diet Mitigate Ischemic Reperfusion–Induced Gastric Ulceration in Experimental Rats

Abstract

Buchholzia coriacea (B. coriacea) seeds, in folk medicine, have been documented to prevent gastric ulceration though the mechanism is not fully elucidated. To clarify this, the gastro-healing activities were investigated using graded incorporation of B. coriacea seeds in the diet. Male Wistar rats (150-200 g) were divided into 7 groups (n = 15): unulcerated untreated control, ulcerated untreated control, unulcerated B. coriacea low (10%), ulcerated B. coriacea low (10%), nulcerated B. coriacea high (25%), ulcerated B. coriacea high (25%), and ulcerated omeprazole-treated groups. Rats were fed with B. coriacea diets for 7 weeks; thereafter, ulcer was induced by ischemic reperfusion method. Daily body weight, gastric acid secretion, hematological parameters, stomach ulcer score, and biochemical and histological analyses were evaluated on days 0, 3, and 7 post-ulcer induction. Results were subjected to one-way analysis of variance (ANOVA) and presented as mean ± standard error of the mean (SEM); p ≤.05 was considered significant. Significant decreases were observed in mean body weight of B. coriacea-fed compared with control and omeprazole-treated groups from week 7. Ulcerated B. coriacea-fed showed significant decrease in gastric acid secretion by days 3 and 7 compared with ulcerated control groups. Malondialdehyde content was significantly decreased in ulcerated B. coriacea-fed compared with control and omeprazole-treated groups. Significant increases in hematological variables (notably platelet count), superoxide dismutase, catalase, and nitric oxide levels of B. coriacea-fed compared with control and omeprazole-treated groups by days 0 and 3 were observed. Histological evaluations further confirmed these observations. B. coriacea diet enhanced gastric healing activities on ischemic reperfused gastric ulcer. Increased platelet count and nitric oxide levels may play significant roles in this process.

Hydroethanolic Extract of Buchholzia coriacea Seeds Alleviates LPS Induced Liver Injury in Rat via Antioxidant and Anti-inflammatory Actions

“…The increase may be due to the decrease in the level of serum and hepatic antioxidant defences. The anti-lipid peroxidation activity exhibited by HEBCS in this study supports the recent report by Salami et al [54] on reduction in MDA levels after ingestion of diets supplemented with Seeds of Buchholzia coriacea.…”

Intestinal Handling of Glucose in <i>Buccholzia coriacea</i> Treated Male Wistar Rats

“…Owonikoko et al [16] reported that Buchholzia coriacea seeds in diet hastened gastric ulcer curative rate in acetic acid induced gastric ulcer in rats. Similar report by Salami et al [17] on Buchholzia coriecea treatment and ischemia-reperfusion gastric ulcer reported better healing rate ascribed to its ability to suppress gastric acid secretion. More notably for this study is the anti-hyperglycemic and the anti-diabetic properties reported for this plant with dearth of knowledge on the role of the intestine in glucose uptake when treated with Buchholzia coriecea.…”

Anti-ulcer property of methanol fraction of Callichilia subsessilis leaf extract in albino rats

“…Free radicals and lipid peroxidation play a pivotal role in the pathogenesis of indomethacin-and ethanolinduced gastric ulcer (Sabiu et al, 2015;Sahoo et al, 2016;Sistani et al, 2019). Antioxidants mop up free radicals and inhibit lipid peroxidation thus, useful in the amelioration of gastric ulcer (Salami et al, 2018). The anti-ulcer activity of MFCS could be linked to its antioxidant potentials.…”