Seedlings Lacking the PTM Protein Do Not Show a <i>genomes uncoupled (gun)</i> Mutant Phenotype

Page, Mike T.; Kacprzak, Sylwia; Mochizuki, Naoki; Okamoto, Haruko; Smith, Alison G.; Terry, Matthew J.

doi:10.1104/pp.16.01930

Cited by 43 publications

(56 citation statements)

References 32 publications

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“…Whether 580 or not the involvement of GUN1 is also indicative of an involvement of retrograde signaling in 581 the regulation of flowering time, remains to be determined. Although a role of chloroplast 582 retrograde signals in the regulation of high light-induced early flowering was proposed and the 583 activation of FLOWERING LOCUS C was suggested as a possible mechanism (Feng et al, 2016), 584 the connection between retrograde signaling and high light-induced flowering was refuted by a 585 recent study (Page et al, 2017) and is also not supported by our data presented here 586 (Supplemental Fig. S6).…”

Section: Overexpression Of Gun1 Confers Early Flowering 443contrasting

confidence: 55%

“…Although chloroplast retrograde signals have 458 been implicated in the promotion of flowering by high light (Feng et al, 2016), these results 459 were recently refuted by the demonstration that the suggested functional connection (the 460 transcription factor PTM) plays no role in retrograde signaling (Page et al, 2017). In an attempt 461 to resolve this controversy, we sought to examine whether or not GUN1 participates in high 462 light-induced early flowering.…”

Section: Overexpression Of Gun1 Confers Early Flowering 443mentioning

confidence: 99%

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Control of Retrograde Signaling by Rapid Turnover of GENOMES UNCOUPLED1

et al. 2018

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Section: Overexpression Of Gun1 Confers Early Flowering 443contrasting

confidence: 55%

Section: Overexpression Of Gun1 Confers Early Flowering 443mentioning

confidence: 99%

Control of Retrograde Signaling by Rapid Turnover of GENOMES UNCOUPLED1

et al. 2018

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“…The question of whether a weaker nuclear gene expression indicates the action of a negative signal or the missing action of a positive signal has been debated in the past (Pfannschmidt, 2010;Terry and Smith, 2013;Hills et al, 2015). A recent study (Page et al, 2017a(Page et al, , 2017b and our data presented here indicate that the action of both positive and negative signals needs to be considered in current models.…”

Section: Retrograde Control Of Nuclear Gene Expression By Biogenic Plmentioning

confidence: 73%

“…Proteins proposed to act as plastid signals include envelope-tethered eukaryotic transcription factors TFIIB-like and PTM, both being released from the outer plastid membrane by targeted proteolysis (Lagrange et al, 2003;Sun et al, 2011) and a plastid localized Whirly1 protein that is released from plastids upon stress (Isemer et al, 2012). A very recent study, however, puts this particular function of PTM in retrograde signaling into question (Page et al, 2017a(Page et al, , 2017b. Most of these retrograde signaling molecules are discussed as stress signals operating from fully developed chloroplasts.…”

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confidence: 99%

Light and Plastid Signals Regulate Different Sets of Genes in the Albino Mutant Pap7-1

et al. 2017

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Plants possessing dysfunctional plastids due to defects in pigment biosynthesis or translation are known to repress photosynthesisassociated nuclear genes via retrograde signals from the disturbed organelles toward the nucleus. These signals are thought to be essential for proper biogenesis and function of the plastid. Mutants lacking plastid-encoded RNA polymerase-associated proteins (PAPs) display a genetic arrest in eoplast-chloroplast transition leading to an albino phenotype in the light. Retrograde signaling in these mutants, therefore, could be expected to be similar as under conditions inducing plastid dysfunction. To answer this question, we performed plastome-and genomewide array analyses in the pap7-1 mutant of Arabidopsis (Arabidopsis thaliana). In parallel, we determined the potential overlap with light-regulated expression networks. To this end, we performed a comparative expression profiling approach using light-and dark-grown wild-type plants as relative control for the expression profiles obtained from lightgrown pap7-1 mutants. Our data indicate a specific impact of retrograde signals on metabolism-related genes in pap7-1 mutants reflecting the starvation situation of the albino seedlings. In contrast, light regulation of PhANGs and other nuclear gene groups appears to be fully functional in this mutant, indicating that a block in chloroplast biogenesis per se does not repress expression of them as suggested by earlier studies. Only genes for light harvesting complex proteins displayed a significant repression indicating an exclusive retrograde impact on this gene family. Our results indicate that chloroplasts and arrested plastids each emit specific signals that control different target gene modules both in positive and negative manner.

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“…Furthermore, the cleaved N-PTM form was shown to directly control the 150 expression of transcription factors, such as Abscisic Acid Insensitive4 (ABI4), in the nucleus 151 (Sun et al, 2011). The gun phenotype of the ptm mutant was recently challenged after analysis 152 of three ptm mutant alleles (Page et al, 2017a), and alternative pathways for the transduction of 153 the plastid signal to the nucleus were suggested. An alternative for the control of ABI4 activity 154 in response to a retrograde signal is a calcium-dependent, three-component mitogen-activated 155 protein kinase (MAPK) system.…”

mentioning

confidence: 99%