Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Ihsan Dereli,
Vladyslav Telychko,
Frantzeskos Papanikos
et al.
Abstract:Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in most organisms. DSBs initiate recombination-mediated linking of homologous chromosomes, which enables correct chromosome segregation in meiosis. DSBs are generated on chromosome axes by heterooligomeric focal clusters of DSB-factors. Whereas DNA-driven protein condensation is thought to assemble the DSB-machinery, its targeting to chromosome axes is poorly understood. We uncover in mice that efficient biogenesis of DSB-machin… Show more
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