Agronomic practices improve seed yield by regulating seed yield components, and the relationship between seed yield and seed yield components is still unclear in smooth bromegrass (Bromus inermis). To optimize seed production and yield in smooth bromegrass, a five-year field trial was designed with split-split-plot to study the combined effects of row spacing (30, 45, 60, and 75 cm), phosphorus (0, 60, 90, and 120 kg P ha−1) and nitrogen (0 and 100 kg N ha−1) on seed yield and seed yield components including fertile tillers m−2 (FTs), spikelets per fertile tiller (SFT), florets per spikelet (FS), and seeds per spikelet (SS). The results showed that FTs as a key factor had a positive effect to seed yield with the biggest pathway coefficient, while SS had a negative effect. Meanwhile, an interaction effect between FTs and SS was observed. FS and SS were increased with phosphorus application under the condition of sufficient nitrogen. In addition, sufficient precipitation at the non-growing season resulted in more FTs in the next year in rain-fed regions. Therefore, the optimum seed yield of smooth bromegrass can be obtained with row spacing (45 cm), nitrogen (100 kg N ha−1), and phosphorus application (60 kg P ha−1).