Sedimentation rate and suPAR in relation to disease activity and mortality in patients with tuberculosis

Abstract

OBJECTIVE: To investigate how levels of the soluble urokinase plasminogen activator receptor (suPAR) and erythrocyte sedimentation rate (ESR) correlate with disease activity and prognosis in pulmonary tuberculosis (PTB).DESIGN: This was a retrospective analysis of patients with active PTB (n = 500) in Gondar, Ethiopia, for whom the suPAR (n = 301) and ESR (n = 330) were analysed at the start of treatment. Both biomarkers were available for 176 patients. Human immunodeficiency virus (HIV) status, chest X-ray (CXR) findings, classification according to the clinical TBscore and treatment outcome were all recorded.RESULTS: In a multivariable logistic regression analysis adjusted for age, sex and HIV status, surrogate markers of disease activity such as advanced CXR patterns correlated with increased levels of suPAR (adjusted OR [aOR] 8.24, P < 0.001) and of ESR (aOR 1.63, P = 0.030), whereas ESR only correlated significantly with a TBscore >6 points. Increased levels of both suPAR and ESR were associated with unsuccessful treatment outcomes (aOR 2.93, P = 0.013; aOR 2.52, P = 0.025). The highest quartile of suPAR (aOR 13.3, P = 0.029) but not ESR levels correlated independently with increased mortality.CONCLUSION: SuPAR and ESR levels correlate with disease activity in PTB; however, the clinical role of these potentially prognostic biomarkers needs to be verified in prospective studies.

Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal

“…We found similar hemoglobin values in both our groups which were also similar in age and may not have been in the chronic stage of TB infection. The ESR is considered a nonspecific indicator of inflammation and infection and can be an indicator of pulmonary TB infection in humans [1], usually associated with chronic infection [34]. We did not find an association between the ESR and seroreactivity in our study.…”

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19

“…Apart from urokinase plasminogen activator (uPA, also known as urokinase), uPAR interacts and cooperates with many ligands and receptors, primarily integrins, to facilitate intracellular signalling, cell migration, cell adhesion and tissue remodelling (20). Soluble uPAR (suPAR) results from proteolytic cleavage of uPAR (21), and has gained increased interest as circulating levels are found to reflect severity and prognosticate outcome of several malignant (22)(23)(24)(25)(26), autoimmune (27)(28)(29)(30) and infectious diseases (31)(32)(33)(34)(35)(36)(37). Additionally, suPAR is used in triaging of patients in acute care settings to early predict clinical deterioration due to suspected bacterial infections (38)(39)(40)(41)(42).…”

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

“…This situation is thought to reflect the fact that the control group selected in our study had diseases that could be confused with CCHF, both clinically and in laboratory findings. In our study, the most common diagnoses in the control group were again infectious diseases such as brucellosis, influenza, and pneumonia, and suPAR levels have been reported to increase in infectious diseases like pneumonia, brucellosis, pancreatitis, sepsis, tuberculosis, and malaria (22,(26)(27)(28)(29)(30).…”