Sedimentation rate and serum thymidine kinase activity: Prognostic factors in squamous cell head and neck cancer

Fontana, Xavier; Dassonville, O.; Néri, Joël; Vallicioni, J; Santini, J.; Milano, Gérard; Combon, Pierre; Lapalus, F.; Démard, F

doi:10.1002/hed.2880150510

Cited by 4 publications

(2 citation statements)

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“…Although elevated TK1 activity has been observed in a variety of human solid tumours, 7, 19–25 surveys to date have identified few canine solid tumours with elevated TK1 activity. In four published investigations, increased TK activity was detected in only 5 of 83 canine solid tumour patients 27–30 .…”

Section: Discussionmentioning

confidence: 99%

“…Circulating TK1 activity correlates with the presence of disease, proliferative capacity and/or clinical stage/sub‐stage for many human haematopoietic tumours including lymphoma (LSA), 5–9 multiple myeloma, 10–12 leukaemias 13–17 and myelodysplastic syndromes 17,18 . While TK1 activity appears to be elevated less frequently in people with solid tumours, elevations have been detected in patients with carcinomas of lung, breast, prostate, gastrointestinal tract and cervix among others 7,19–25 . Furthermore, both one‐time and serial TK1 measurements may have prognostic or predictive value in human leukaemia, LSA and multiple human carcinomas 5–12,25 .…”

Section: Introductionmentioning

confidence: 99%

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Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma^*

Thamm

Kamstock

Sharp

et al. 2011

Vet Comparative Oncology

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Thymidine kinase 1 (TK1) is a soluble biomarker associated with DNA synthesis. This prospective study evaluated serum TK1 activity in dogs presenting with hemoabdomen and a splenic mass. An ELISA using azidothymidine as a substrate was used to evaluate TK1 activity. Sixty-two dogs with hemoabdomen and 15 normal controls were studied. Serum TK1 activity was significantly higher in dogs with hemangiosarcoma (HSA) than in normal dogs (mean ± SEM = 17.0 ± 5.0 and 2.01 ± 0.6, respectively), but not dogs with benign disease (mean ± SEM = 10.0 ± 3.3). Using a cut-off of 6.55 U/L, TK activity demonstrated a sensitivity of 0.52, specificity of 0.93, positive predictive value of 0.94 and negative predictive value of 0.48 for distinguishing HSA versus normal. When interval thresholds of <1.55 and >7.95 U/L were used together, diagnostic utility was increased. Serum TK1 evaluation may help to discriminate between benign disease and HSA in dogs with hemoabdomen and a splenic mass.

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Section: Discussionmentioning

confidence: 99%