Sedentary time has a negative influence on bone mineral parameters in peripubertal boys: a 1-year prospective study

Ivuškāns, Artūrs; Mäestu, Evelin; Jürimäe, Toivo; Lätt, Evelin; Purge, Priit; Minha, Sa’ar; Maasalu, Katre; Jürimäe, Jaak

doi:10.1007/s00774-013-0556-4

Cited by 36 publications

(62 citation statements)

References 30 publications

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“…The association was classified as ‘inconsistent/uncertain’ for all studies (4/8), low ROB studies (1/3) and those that adjusted for MVPA (1/4). One longitudinal study that was not classified as low ROB reported that total sedentary time was negatively associated with bone mineral content and density of the femoral neck over 12 months in 11‐ to 13‐year‐olds ( n = 169) . Another study that was not classified as low ROB found that breaks in bouts of sedentary time were not significantly associated with bone outcomes in children and adolescents aged 9–20 years ( n = 206) .…”

Section: Resultsmentioning

confidence: 99%

Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis

et al. 2016

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Sedentary behaviour has emerged as a unique determinant of health in adults. Studies in children and adolescents have been less consistent. We reviewed the evidence to determine if the total volume and patterns (i.e. breaks and bouts) of objectively measured sedentary behaviour were associated with adverse health outcomes in young people, independent of moderate-intensity to vigorous-intensity physical activity. Four electronic databases (EMBASE MEDLINE, Ovid EMBASE, PubMed and Scopus) were searched (up to 12 November 2015) to retrieve studies among 2-to 18-year-olds, which used cross-sectional, longitudinal or experimental designs, and examined associations with health outcomes (adiposity, cardio-metabolic, fitness, respiratory, bone/musculoskeletal, psychosocial, cognition/academic achievement, gross motor development and other outcomes). Based on 88 eligible observational studies, level of evidence grading and quantitative meta-analyses indicated that there is limited available evidence that the total volume or patterns of sedentary behaviour are associated with health in children and adolescents when accounting for moderate-intensity to vigorous-intensity physical activity or focusing on studies with low risk of bias. Quality evidence from studies with robust designs and methods, objective measures of sitting, examining associations for various health outcomes, is needed to better understand if the overall volume or patterns of sedentary behaviour are independent determinants of health in children and adolescents. and health outcomes in children and adolescents (2-18 years). The review was registered with 48 PROSPERO (CRD42014009084) and reported using the Preferred Reporting Items for Systematic 49Reviews and Meta-Analyses (PRISMA) (26). The search was not delimited by date restrictions but 50 only included studies published in English. Studies were included if they met the following criteria: 51 52

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Section: Resultsmentioning

confidence: 99%

Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis

et al. 2016

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“…However, whether sedentary time independently influences health outcomes or simply displaces other forms of PA is currently debatable . A focus upon the consequences of “not loading” a healthy growing skeleton is relatively new, and only four DXA studies and one HR‐pQCT study investigated the relationship between objectively measured sedentary time and bone in adolescents, with contradictory findings . A recent systematic review suggested there was insufficient evidence to fully support an association between sedentary time and bone health, independent of PA .…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Sedentary Time, and Bone Strength From Childhood to Early Adulthood: A Mixed Longitudinal HR-pQCT study

Gabel

Macdonald

Nettlefold

et al. 2017

Journal of Bone and Mineral Research

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Bone strength is influenced by bone geometry, density, and bone microarchitecture, which adapt to increased mechanical loads during growth. Physical activity (PA) is essential for optimal bone strength accrual; however, less is known about how sedentary time influences bone strength and its determinants. Thus, our aim was to investigate the prospective associations between PA, sedentary time, and bone strength and its determinants during adolescence. We used HR-pQCT at distal tibia (8% site) and radius (7% site) in 173 girls and 136 boys (aged 9 to 20 years at baseline). We conducted a maximum of four annual measurements at the tibia (n = 785 observations) and radius (n = 582 observations). We assessed moderate-to-vigorous PA (MVPA) and sedentary time with accelerometers (ActiGraph GT1M). We aligned participants on maturity (years from age at peak height velocity) and fit a mixed-effects model adjusting for maturity, sex, ethnicity, leg muscle power, lean mass, limb length, dietary calcium, and MVPA in sedentary time models. MVPA was a positive independent predictor of bone strength (failure load [F.Load]) and bone volume fraction (BV/TV) at the tibia and radius, total area (Tt.Ar) and cortical porosity (Ct.Po) at the tibia, and negative predictor of load-to-strength ratio at the radius. Sedentary time was a negative independent predictor of Tt.Ar at both sites and Ct.Po at the tibia and a positive predictor of cortical thickness (Ct.Th), trabecular thickness (Tb.Th), and cortical bone mineral density (Ct.BMD) at the tibia. Bone parameters demonstrated maturity-specific associations with MVPA and sedentary time, whereby associations were strongest during early and mid-puberty. Our findings support the importance of PA for bone strength accrual and its determinants across adolescent growth and provide new evidence of a detrimental association of sedentary time with bone geometry but positive associations with microarchitecture. This study highlights maturity-specific relationships of bone strength and its determinants with loading and unloading. Future studies should evaluate the dose-response relationship and whether associations persist into adulthood. © 2017 American Society for Bone and Mineral Research.

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“…The analysis of the correlations between mean PA and bone mineral acquisition complements previously published data [33]. The previous analyses focused solely in the changes in PA participation and consequently did not discriminate those subjects who remained physically active throughout the study from those who showed low levels of PA participation during the same period.…”

Section: Discussionmentioning

confidence: 74%

Vigorous physical activity patterns affect bone growth during early puberty in boys

et al. 2018

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This study aims to analyze the impact of participation in vigorous physical activity as it can promote a healthy bone development. Adolescents who increased their participation in vigorous physical activity showed higher improvements in bone parameters compared to those who did not, which highlights the relevance of vigorous physical activity engagement. Introduction The main purpose of the study was to analyze the effects of different patterns of vigorous physical activity (VPA) on bone development. Methods One-week accelerometry registers and dual-energy X-ray absorptiometry scans at the whole body, hip, and lumbar spine of 140 healthy male adolescents (11-13 years, at baseline) were performed twice with a 1-year interval between measurements. Four patterns of VPA evolution (Blow-low,^Blow-high,^Bhigh-low,^and Bhigh-high^) and three patterns of bone growth (Boptimal,^Bmean,^and Breduced^) were defined according to the median participation in VPA and a cluster analysis of the longitudinal changes in BMC and BMD in all sites measured, respectively. Bone mineral parameters were adjusted for skeletal age and body weight prior to statistical comparison among groups. Results Participants in the Blow-high^group had greater adjusted BMD increases at both the femoral neck and lumbar spine when compared to the Blow-low^group (estimated mean (95%

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Sedentary time has a negative influence on bone mineral parameters in peripubertal boys: a 1-year prospective study

Cited by 36 publications

References 30 publications

Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis

Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis

Physical Activity, Sedentary Time, and Bone Strength From Childhood to Early Adulthood: A Mixed Longitudinal HR-pQCT study

Vigorous physical activity patterns affect bone growth during early puberty in boys

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