Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: a cross-sectional investigation

Mani, Ramakrishnan; Adhia, Divya Bharatkumar; Leong, Sook Ling; Vanneste, Sven; Ridder, Dirk De

doi:10.1097/pr9.0000000000000773

Cited by 19 publications

(26 citation statements)

References 96 publications

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“…Higher physical activity levels can facilitate descending nociceptive inhibitory mechanisms 80,81 . However, a recent study has identified that sedentary behavior is associated with higher pain inhibitory capacity among individuals with chronic musculoskeletal pain 82 . Investigators have suggested that negative psychosocial contexts and altered sensory processing might moderate the effect of physical activity on nociceptive modulatory mechanisms 66,82,83 .…”

Section: Discussionmentioning

confidence: 99%

Relationships Between Psychological, Sleep, and Physical Activity Measures and Somatosensory Function in People With Peripheral Joint Pain: A Systematic Review and Meta‐Analysis

et al. 2020

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Objective Alteration in somatosensory function has been linked to pain experience in individuals with joint pain. In this systematic review we aimed to establish the level of evidence of associations between psychological, social, physical activity, and sleep measures and somatosensory function that were assessed via quantitative sensory testing (QST) among individuals with joint pain. Methods A comprehensive literature search was conducted in 6 electronic databases from their inception to July 2019. Two reviewers independently assessed the methodological quality using a modified Quality in Prognostic Studies (QUIPS) tool and supplemented with recommendations from the Critical Appraisal and Data Extraction for Systematic Review of Prediction Modelling Studies (CHARMS) checklist and the Quality Assessment of Diagnostic Accuracy Studies (QUADAS‐2) tool. The level of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system. Data were pooled to evaluate the strength of the relationships of interest. Results Seventeen studies related to joint pain were included. Pain catastrophizing, depression, anxiety, and physical activity level have been shown to have a significant (small to fair) association with several QST measures. Pressure pain threshold (PPT) is the only measure that was found to be consistently correlated with all the domains. The overall quality of evidence for all factors ranged from very low to moderate. Subgroup analysis revealed a stronger association for depression and pain catastrophizing and PPT and temporal pain summation in individuals with shoulder pain. Conclusion Psychological factors and physical activity levels are associated with somatosensory function in people with joint pain. These factors need to be adjusted when establishing predictive relationships between somatosensory function and pain outcomes in individuals with joint pain.

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Section: Discussionmentioning

confidence: 99%

Relationships Between Psychological, Sleep, and Physical Activity Measures and Somatosensory Function in People With Peripheral Joint Pain: A Systematic Review and Meta‐Analysis

et al. 2020

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“…The questionnaire consists of 12 items that measure pain quality rated on a 5-point Likert scale (1 = never to 5 = very strongly), pain radiation from the primary area of pain (yes or no), and pain course pattern (scored from −1 to 2). The total score ranges from −1 to 38 points with a score of ≥ 19 indicative of a likely neuropathic pain (≤ 12: nociceptive pain and 13-18: possible neuropathic pain component [or mixed type]; Freynhagen, Tölle, Gockel, & Baron, 2016;Mani et al, 2019).…”

Section: Baseline Assessmentmentioning

confidence: 99%

“…Symptoms of central sensitization will be evaluated by using Central Sensitization Inventory (CSI) questionnaire. The CSI consists of two parts-part A assesses 25 healthrelated symptoms common to central sensitivity syndromes, with a total score ranging from 0 to 100, and part B (is not scored) asks about previous diagnoses of one or more specific disorders, including central sensitivity syndromes (Mani et al, 2019).…”

Section: Central Sensitizationmentioning

confidence: 99%

“…For each trial, MTS will be calculated as the difference between the NRS rating after the first contact and the highest pain rating after the 10th contact. An average of the three trials will be taken for pain rating, with a positive score indicating an increase in MTS (Goodin et al, 2014;Mani et al, 2019).…”

Section: Mechanical Temporal Summation (Mts)mentioning

confidence: 99%

“…Three PPT (P40) trails will be measured at 30, 60, and 90 seconds after immersing the hand. A percentage score will be established for each time point of CPM measurement with a positive score indicating an increase in PPTs (pain4) after the conditioning stimulus and thus presence of CPM effect (Lewis, Luke, Rice Rome, & McNair, 2012;Mani et al, 2019;Nir & Yarnitsky, 2015;.…”

Section: Conditioned Pain Modulation (Cpm)mentioning

confidence: 99%

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Protocol for a Pilot Randomized Sham-Controlled Clinical Trial Evaluating the Feasibility, Safety, and Acceptability of Infraslow Electroencephalography Neurofeedback Training on Experimental and Clinical Pain Outcomes in People with Chronic Painful Knee

Mathew

Adhia²,

Smith³

et al. 2020

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Introduction: Persistent pain is a significant contributor to disability in people living with knee osteoarthritis (KOA). Brain imaging, including electrophysiological studies, confirms altered cortical oscillatory and synchrony patterns in cognitive, affective, and somatosensory areas in individuals with KOA pain. Electroencephalography neurofeedback (EEG-NF) training is a form of neuromodulatory intervention that can help to reduce pain via normalizing dysrhythmic cortical oscillatory patterns that are linked to the pain experience. However, there is a dearth of evidence towards the efficacy of NF in individuals with musculoskeletal pain. Aim: The proposed research is intended to pilot the NF training protocol and assess the feasibility, safety, and acceptability of NF training in individuals with KOA and estimate the variability of experimental and clinical outcome measures following NF training. Design: A parallel, two-armed, double-blind (participant and assessor) pilot randomized sham-controlled clinical trial. Methods: Adults aged 44-75 years with a clinical diagnosis of KOA will be recruited and randomized to either active or sham EEG-NF training. Both groups will receive auditory feedback as a reward for achieving a predetermined activity threshold of the target areas of the brain. Outcome measures include feasibility measures (recruitment, randomization, retention, and dropout rates), acceptability, and adverse events; clinical measures (pain, interference, sleep, mood, and physical activity); and experimental pain outcomes (quantitative sensory testing procedures). Discussion: Outcomes from this study will inform the feasibility and methodology for a future randomized controlled clinical trial.

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Physical activity and cold pain tolerance in the general population

Årnes

Nielsen

Stubhaug

et al. 2020

European Journal of Pain

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Background The relationship between habitual physical activity (PA) and experimental pain tolerance has been investigated in small samples of young, healthy and/or single‐sex volunteers. We used a large, population‐based sample to assess this relationship in men and women with and without chronic pain. Methods We used data from the sixth and seventh Tromsø Study surveys (2007–2008; 2015–2016), with assessed pain tolerance of participants with the cold pressor test (CPT: dominant hand in circulating cold water at 3°C, maximum test time 106 s), and self‐reported total amount of habitual PA in leisure time (n = 19,087), exercise frequency (n = 19,388), exercise intensity (n = 18,393) and exercise duration (n = 18,343). A sub‐sample had PA measured by accelerometers (n = 4,922). We used Cox regression to compare CPT tolerance times between self‐reported PA levels. For accelerometer‐measured PA, we estimated hazard ratios for average daily activity counts, and for average daily minutes of moderate‐to‐vigorous PA done in bouts lasting 10 min or more. Models were tested for PA‐sex, and PA‐chronic pain and PA‐moderate‐to‐severe chronic pain interactions. Results Leisure‐time PA, exercise intensity and exercise duration were positively associated with CPT tolerance (p < .001; p = .011; p < .001). More PA was associated with higher CPT tolerance. At high levels of leisure‐time PA and exercise intensity, men had a significantly higher CPT tolerance than women. Accelerometer‐measured PA was not associated with CPT tolerance. Conclusions This study is one of the first to show that higher self‐reported habitual PA was connected to higher experimental pain tolerance in a population‐based sample, especially for men. This was not found for accelerometer‐measured PA. Significance This study finds that higher level of self‐reported leisure‐time physical activity is associated with increased cold pressor pain tolerance in a large population‐based sample. Though present in both sexes, the association is strongest among men. Despite the robust dose–response relationship between pain tolerance and self‐reported activity level, no such relationship was found for accelerometer‐measured activity, reflecting a possible discrepancy in the aspect of physical activity measured. Though the study design does not permit causal conclusions, the findings suggest that increasing physical activity may increase pain tolerance in the general population.

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Sedentary behaviour facilitates conditioned pain modulation in middle-aged and older adults with persistent musculoskeletal pain: a cross-sectional investigation

Cited by 19 publications

References 96 publications

Relationships Between Psychological, Sleep, and Physical Activity Measures and Somatosensory Function in People With Peripheral Joint Pain: A Systematic Review and Meta‐Analysis

Relationships Between Psychological, Sleep, and Physical Activity Measures and Somatosensory Function in People With Peripheral Joint Pain: A Systematic Review and Meta‐Analysis

Protocol for a Pilot Randomized Sham-Controlled Clinical Trial Evaluating the Feasibility, Safety, and Acceptability of Infraslow Electroencephalography Neurofeedback Training on Experimental and Clinical Pain Outcomes in People with Chronic Painful Knee

Physical activity and cold pain tolerance in the general population

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