Sedentary behaviour and brain health in middle-aged and older adults: A systematic review

Maasakkers, Carlijn M.; Weijs, Ralf W.J.; Dekkers, Claudia; Gardiner, Paul A.; Ottens, Romy; Rikkert, Marcel G M Olde; Melis, René J.F.; Thijssen, Dick H. J.; Claassen, Jurgen A.H.R.

doi:10.1016/j.neubiorev.2022.104802

Cited by 10 publications

(13 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the numerous advantages that the Internet offers, it has contributed to a notable rise in sedentary behavior across the population 88 , which in turn could impact attention, memory and other cognitive aspects 89 . The strongest empirical evidence supporting this possibility, sometimes referred to as the "displacement hypothesis", is provided by various meta-analyses and reviews that have either specifically investigated the association between sedentary behavior and cognition [90][91][92][93] , or examined the relationships between multiple lifestyle factors (including sedentary behavior) and cognitive outcomes 94,95 . The findings consistently indicate that higher levels of sedentary behavior are linked to reduced cognitive function and heightened risk of cognitive dysfunction across the lifespan 96 .…”

Section: The Offline Effects Of An Online World: Implications For Bod...mentioning

confidence: 99%

From “online brains” to “online lives”: understanding the individualized impacts of Internet use across psychological, cognitive and social dimensions

Firth,

Torous,

López‐Gil

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

In response to the mass adoption and extensive usage of Internet‐enabled devices across the world, a major review published in this journal in 2019 examined the impact of Internet on human cognition, discussing the concepts and ideas behind the “online brain”. Since then, the online world has become further entwined with the fabric of society, and the extent to which we use such technologies has continued to grow. Furthermore, the research evidence on the ways in which Internet usage affects the human mind has advanced considerably. In this paper, we sought to draw upon the latest data from large‐scale epidemiological studies and systematic reviews, along with randomized controlled trials and qualitative research recently emerging on this topic, in order to now provide a multi‐dimensional overview of the impacts of Internet usage across psychological, cognitive and societal outcomes. Within this, we detail the empirical evidence on how effects differ according to various factors such as age, gender, and usage types. We also draw from new research examining more experiential aspects of individuals’ online lives, to understand how the specifics of their interactions with the Internet, and the impact on their lifestyle, determine the benefits or drawbacks of online time. Additionally, we explore how the nascent but intriguing areas of culturomics, artificial intelligence, virtual reality, and augmented reality are changing our understanding of how the Internet can interact with brain and behavior. Overall, the importance of taking an individualized and multi‐dimensional approach to how the Internet affects mental health, cognition and social functioning is clear. Furthermore, we emphasize the need for guidelines, policies and initiatives around Internet usage to make full use of the evidence available from neuroscientific, behavioral and societal levels of research presented herein.

show abstract

Section: The Offline Effects Of An Online World: Implications For Bod...mentioning

confidence: 99%

From “online brains” to “online lives”: understanding the individualized impacts of Internet use across psychological, cognitive and social dimensions

Firth,

Torous,

López‐Gil

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

show abstract

“…A sedentary lifestyle has been associated with decreased brain activity, cognitive function and brain structural remodelling, being also considered a risk factor for several neurological disorders, including dementia. 102,[104][105][106] This may be due, in part, to a blunted release of myokines involved in muscle-brain crosstalk (e.g. BDNF and IGF-1) 107 and impaired cerebrovascular perfusion 105 with physical inactivity.…”

Section: Unexplored Topic Ii: Does Sr Impact Brain Activity Neurogene...mentioning

confidence: 99%

“…102,[104][105][106] This may be due, in part, to a blunted release of myokines involved in muscle-brain crosstalk (e.g. BDNF and IGF-1) 107 and impaired cerebrovascular perfusion 105 with physical inactivity. The brain's adaptations in function and structure, as well as the physiological factors that contribute to these changes, are largely unexplored in SR studies.…”

Section: Unexplored Topic Ii: Does Sr Impact Brain Activity Neurogene...mentioning

confidence: 99%

Pathophysiological mechanisms of reduced physical activity: Insights from the human step reduction model and animal analogues

et al. 2023

View full text Add to dashboard Cite

Physical inactivity represents a heavy burden for modern societies and is spreading worldwide, it is a recognised pandemic and is the fourth cause of global mortality. Not surprisingly, there is an increasing interest in longitudinal studies on the impact of reduced physical activity on different physiological systems. This narrative review focuses on the pathophysiological mechanisms of step reduction (SR), an experimental paradigm that involves a sudden decrease in participants' habitual daily steps to a lower level, mimicking the effects of a sedentary lifestyle. Analogous animal models of reduced physical activity, namely, the “wheel‐lock” and the “cage reduction” models, which can provide the foundation for human studies, are also discussed. The empirical evidence obtained thus far shows that even brief periods of reduced physical activity can lead to substantial alterations in skeletal muscle health and metabolic function. In particular, decrements in lean/muscle mass, muscle function, muscle protein synthesis, cardiorespiratory fitness, endothelial function and insulin sensitivity, together with an increased fat mass and inflammation, have been observed. Exercise interventions seem particularly effective for counteracting these pathophysiological alterations induced by periods of reduced physical activity. A direct comparison of SR with other human models of unloading, such as bed rest and lower limb suspension/immobilisation, is presented. In addition, we propose a conceptual framework aiming to unravel the mechanisms of muscle atrophy and insulin resistance in the specific context of reduced ambulatory activity. Finally, methodological considerations, knowledge gaps and future directions for both animal and human models are also discussed in the review.

show abstract

“…[6][7][8] Although physical activity (PA) is a protective factor for brain volume and is associated with increased brain volume in older adults, 9,10 older adults are inclined to decrease PA and increase sedentary time (ST). [11][12][13] Vulnerable older adults, including those who have physical frailty and cognitive impairment, find it difficult to engage in PA and are prone to more ST. [14][15][16][17] A recent systematic review reported a negative association between ST and brain structure: 18 ST is negatively associated with total brain volume, 19 cortical thickness, 20 and white matter volume. 21 Therefore, especially in vulnerable older adults, protective factors against brain atrophy should be identified.…”

Section: Introductionmentioning

confidence: 99%

“…Vulnerable older adults, including those who have physical frailty and cognitive impairment, find it difficult to engage in PA and are prone to more ST 14–17 . A recent systematic review reported a negative association between ST and brain structure: 18 ST is negatively associated with total brain volume, 19 cortical thickness, 20 and white matter volume 21 . Therefore, especially in vulnerable older adults, protective factors against brain atrophy should be identified.…”

Section: Introductionmentioning

confidence: 99%

Cross‐sectional associations between sedentary time with cognitive engagement and brain volume among community‐dwelling vulnerable older adults

Kurita,

Tsutsumimoto,

Kiuchi

et al. 2023

Geriatrics Gerontology Int

View full text Add to dashboard Cite

AimsVulnerable older adults tend to decrease physical activity (PA) and increase sedentary time (ST). Previous research on the associations between ST and brain volume have yielded inconsistent findings, without considering the impact of cognitive engagement (CE) on cognitive function. We aimed to examine the association between ST with CE and brain volume.MethodsA structural magnetic resonance imaging survey was conducted among community‐dwelling vulnerable older adults. Brain volumetric measurements were obtained using 3T magnetic resonance imaging and pre‐processed using FreeSurfer. ST with low or high CE was assessed using a 12‐item questionnaire. PA was assessed by the frequency of light and moderate levels of physical exercise according to the Japanese version of the Cardiovascular Health Study criteria. Participants were categorized into a low PA group and a moderate‐to‐high PA group.ResultsAmong 91 participants (83.1 ± 5.2 years old, 61.5% female), 26 were low PA. The overall sample and moderate‐to‐high PA group did not show significant positive associations with brain volume for ST with high CE. In the low PA group, isotemporal substitution models showed that replacing ST with low CE by ST with high CE was significantly associated with increased brain volume in some areas, including the rostral and caudal anterior cingulate (β = 0.486–0.618, all P < 0.05, adjusted R2 = 0.344–0.663).ConclusionsOur findings suggest that replacing ST with low CE by ST with high CE is positively associated with brain volume in vulnerable older adults with low PA. Geriatr Gerontol Int 2024; 24: 82–89.

show abstract

Sedentary behaviour and brain health in middle-aged and older adults: A systematic review

Cited by 10 publications

References 61 publications

From “online brains” to “online lives”: understanding the individualized impacts of Internet use across psychological, cognitive and social dimensions

From “online brains” to “online lives”: understanding the individualized impacts of Internet use across psychological, cognitive and social dimensions

Pathophysiological mechanisms of reduced physical activity: Insights from the human step reduction model and animal analogues

Cross‐sectional associations between sedentary time with cognitive engagement and brain volume among community‐dwelling vulnerable older adults

Contact Info

Product

Resources

About