Sedentary behavior is associated with impaired biomarkers in claudicants

Farah, Breno Q.; Ritti‐Dias, Raphael Mendes; Montgomery, Polly S.; Casanegra, Ana I.; Silva-Palacios, Federico; Gardner, Andrew W.

doi:10.1016/j.jvs.2015.09.018

Cited by 18 publications

(19 citation statements)

References 41 publications

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“…residents of metropolitan cities) recruited from the database of studies developed and published before the COVID-19 pandemic by our group. 1 , 3 , 4 , 5 , 11 , 12 , 13 This study was approved by the Universidade Nove de Julho’ Ethics Committee before data collection (CAAE #31529220.8.0000.5511). All participants verbally gave informed consent by phone prior to participation.…”

Section: Methodsmentioning

confidence: 99%

Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study

Ritti‐Dias

Correia

Carvalho

et al. 2022

Journal of Vascular Nursing

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Background Social isolation has been one of the main strategies to prevent the spread of Coronavirus 2019 (COVID-19). However, the impact of social isolation on the lifestyle of patients with peripheral artery disease (PAD) and claudication symptoms remains unclear. Objectives To analyze the perceptions of patients with PAD of the impact of social isolation provoked by COVID-19 pandemic on health lifestyle. Design Cross-sectional. Setting The database of studies developed by our group involving patients with PAD from public hospitals in São Paulo. Methods In this cross-sectional survey study, 136 patients with PAD (61% men, 68±9 years old, 0.55±0.17 ankle-brachial index, 82.4% with a PAD diagnosis ≥5 years old) were included. Health lifestyle factors were assessed through a telephone interview using a questionnaire containing questions related to: (a) COVID-19 personal care; (b) mental health; (c) health risk habits; (d) eating behavior; (e) lifestyle; (f) physical activity; (g) overall health; and (h) peripheral artery disease health care. Results The majority of patients self-reported spending more time watching TV and sitting during the COVID-19 pandemic and only 28.7% were practicing physical exercise. Anxiety and unhappiness were the most prevalent feelings self-reported among patients and 43.4% reported a decline in walking capacity. Conclusion Most patients with PAD self-reported increased sedentary behavior, lower physical activity level, and worse physical and mental health during the COVID-19 pandemic. Thus, it is necessary to adopt strategies to improve the quality of life of these patients during this period.

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Section: Methodsmentioning

confidence: 99%

Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study

Ritti‐Dias

Correia

Carvalho

et al. 2022

Journal of Vascular Nursing

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“…Previous studies in non-PAD subjects showed that sedentary behavior is associated with fatal and nonfatal cardiovascular disease, and all-cause mortality independent of physical activity level 11, 12 . In patients with symptomatic PAD, sedentary behavior was associated with worse inflammation, coagulation, glucose, and lipid profiles 13 and greater functional decline 8 .…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Sedentary Behavior in Patients with Intermittent Claudication

Farah¹,

Ritti‐Dias²,

Cucato³

et al. 2016

European Journal of Vascular and Endovascular Surgery

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Objectives Time spent in sedentary behavior has been associated with cardiometabolic risk factor in the general population and in patients with symptomatic peripheral artery disease (PAD). Given the association of sedentary behavior and poor health outcomes, it is important to identify factors associated of sedentary behavior in these patients. The aim of this study was to identify factors associated with the sedentary time in patients with symptomatic PAD. Methods The sample included 297 patients with symptomatic PAD. Sedentary behavior was assessed using a step activity monitor and the patients were divided into tertiles. Demographic data, body mass index, comorbid conditions, and measures of severity of PAD (ankle-brachial index, ischemic window, claudication measurements, peak oxygen uptake and walking economy) were obtained. Results Patients in the highest tertile (i.e., more sedentary) have a higher body mass index and a higher prevalence of diabetes mellitus, metabolic syndrome and obesity than patients in the lowest tertile, whereas their peak walking time, peak oxygen uptake and walking economy were lower (P<.05 for all). Using multiple regression procedures, the factors associated of the sedentary time were male sex (b=0.217, R2=0.180, p=0.001), body mass index (b=0.154, R2=0.059, p=0.013), peak walking time (b=−0.360, R2=0.066, p=<0.001) and walking economy (b=−0.187, R2=0.142, p=0.004). Conclusion In patients with symptomatic PAD, greater time spent in sedentary behavior was found in men, and in patients with higher body mass index, lower peak walking time, and lower walking economy.

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“…Only two previous studies explored the association between hemostatic markers and SB through objective assessment, in older men [20] and patients with symptoms of peripheral arterial disease [21]. In the study of Farah et al, SB remained associated with fibrinogen after adjustment for sex, age, PA status, BMI, and severity of peripheral arterial disease [21]. Parsons et al found an association between sedentary time and some fibrinolytic markers but they did not assess fibrinogen [20].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in these researches, neither PA nor SB were objectively assessed. Only two studies explored the association between inflammatory/hemostatic markers and objectively assessed SB, in older men [20] and patients with intermittent claudication [21]. We sought to explore the correlation between objectively measured SB and circulating fibrinogen levels in postmenopausal women, a population particularly susceptible to increase the risk of CVD due to changes in hemostatic parameters [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Length and Number of Sedentary Bouts Predict Fibrinogen Levels in Postmenopausal Women

Izzicupo

Blasio

Credico

et al. 2020

IJERPH

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Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p < 0.01), lying down during awake time (r = −0.50, p < 0.01), and both medium (11–30 mins) and very long bouts (>1 h) of SB (r = −0.59, p < 0.01; r = −0.51, p < 0.01, respectively), and inversely correlated with moderate to vigorous-intensity physical activity (r = −0.39, p < 0.01). Furthermore, fibrinogen was also directly correlated with BMI (r = −0.28, p < 0.05). In postmenopausal women without prevalent cardiovascular disease, the number of prolonged and uninterrupted sedentary bouts is directly correlated with increased fibrinogen levels, regardless of PA and BMI. This result suggests the importance of delivering new strategies to counteract the increase of sedentariness and inactivity of the postmenopausal population.

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Sedentary behavior is associated with impaired biomarkers in claudicants

Cited by 18 publications

References 41 publications

Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study

Impact of the COVID-19 pandemic on health lifestyle in patients with peripheral artery disease: A cross-sectional study

Factors Associated with Sedentary Behavior in Patients with Intermittent Claudication

The Length and Number of Sedentary Bouts Predict Fibrinogen Levels in Postmenopausal Women

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