Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice

Walle, Muluken

doi:10.11648/j.ajbls.20140204.12

Cited by 8 publications

(9 citation statements)

References 23 publications

(13 reference statements)

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“…Data from the literature reported similar effects of newly synthesized analogues of myrtenal on the GABA-ergic system (100). Similar results for improved hypnotic effects of barbiturates in mice have been reported for Myrtus communis essential oil and water-alcohol plant extract (101,102). Our data of myrtenal's potentiating activity on classic hypnotic drugs (barbiturates) effects in combination (103) also confirm the results obtained by other researchers (77).…”

Section: Biological Effects Of Bicyclic Monoterpenoid Myrtenal (Alone)supporting

confidence: 90%

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Dragomanova

Tancheva

Georgieva

2018

Scripta Scientifica Pharmaceutica

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INTRODUCTION: Myrtenal, a component of many plants' essential oils, is a bicyclic monoterpenoid. Numerous effects of myrtenal in experimental animals have been found-bronchodilatory, anti-inflammatory, anti-aggregative and antihemolytic (in vitro), and antibacterial. Its other activities have been studiedantioxidant, antitumor, antihyperglycemic, vasodilating, heart rate reducing and hypotensive. Myrtenal is relatively little studied in the field of neuroscience. AIM: The aim of this article is to summarize the available information on the established biological activity of the monoterpenoid myrtenal. MATERIALS AND METHODS: Scientific databases such as PubMed, ResearchGate, HMDB and others have been used to provide information on the published results of properties and activities of the test substance (myrtenal) over a period of 15 years (2003-2018). RESULTS: Our research confirmed the available data for its central nervous system (CNS) activity-anxiolytic and potentiating the effects of the hypnotic drugs, as well as the antioxidant properties. We have evaluated the neuromodulatory activity of M in brain tissue manifested in elevated levels of major neurotransmitters in healthy rodents and those with neurodegenerative changes accompanied by improvement in the animals' memory. CONCLUSION: Significant protective effects of myrtenal on neurodegenerative processes were established. Probably they are related to its complex mechanisms, including neuromodulatory and antioxidant properties.

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Section: Biological Effects Of Bicyclic Monoterpenoid Myrtenal (Alone)supporting

confidence: 90%

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Dragomanova

Tancheva

Georgieva

2018

Scripta Scientifica Pharmaceutica

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“…In Ethiopia, it is commonly called “addus” in Amharic. 3 – 7 It is grown in gardens of Addis Ababa. The plant is much more widespread than the herbarium collections indicate.…”

Section: Introductionmentioning

confidence: 99%

“…In one of our previous studies, the EO from the leaves of this plant was shown to have a muscle relaxing effect and also potentiate the hypnotic effect of pentobarbital. 7 …”

Section: Introductionmentioning

confidence: 99%

Hypnotic effect of the essential oil from the leaves of <em>Myrtus communis</em> on mice

Birhanie¹,

Walle²,

Rebba

2016

NSS

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BackgroundMyrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous studies have also indicated its sedative- and hypnotic-like activity. In this study, the hypnotic effect of M. communis was investigated.MethodsEssential oil (EO) of M. communis (600, 800, and 1,000 mg/kg) was given orally to Swiss albino mice of both sex, and the hypnotic effect was evaluated. In addition, the EO of M. communis (500, 600, 800, and 1,000 mg/kg) was administered orally to Swiss albino mice of both sex 60 minutes prior to pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. The effect of the EO on motor coordination and muscle relaxation was evaluated using chimney and traction tests, 60 and 90 minutes after administration of the respective doses of the EO, respectively.ResultsThere was no induction of hypnosis as the presence of the righting reflex was intact. However the EO prolonged pentobarbital-induced sleeping time and there was also 50% negative response on the chimney and traction test in a dose dependent manner.ConclusionThe EO of M. communis did not produce a hypnotic effect, but it potentiated a hypnotic effect with significant central nervous system depressant activity.

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“…The essential oil of common myrtle revealed sedative-hypnotics. 68 Two years later, another controversial finding revealed that there was no induction of hypnosis. However, the myrtle oil prolonged pentobarbital-induced sleeping time and there was also half (50%) negative response on the chimney and traction test in a dose-dependent manner.…”

Section: Ethnopharmacological Studiesmentioning

confidence: 99%

Ethnobotanical, Ethnopharmacological, and Phytochemical Studies of Myrtus communis Linn: A Popular Herb in Unani System of Medicine

Sisay

Gashaw

2017

J Evid Based Complementary Altern Med

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Myrtus communis L (Myrtaceae) is one of the popular drugs being used in the Unani system of phytomedicine since ancient Greece period. From time immemorial, different parts of this plant and essential oil have been used for a variety of purposes such as cosmetics (hair fall control), flavoring of food and drinks as well as extensive therapeutic purposes. Ethnobotanical information revealed that M communis L has been a folkloric repute for the treatment of several diseases like gastric ulcer, diarrhea, dysentery, cancer, rheumatism, hemorrhage, deep sinuses, leucorrhoea, hemorrhoid, inflammation, dyspepsia, anxiety, insomnia, diabetes, hypertension, pulmonary disorders, and skin diseases. Moreover, ethnopharmacological studies revealed that the plant is endowed with extensive pharmacological activities, including antimicrobial, antidiarrheal, antidiabetic, antispasmodic, vasodilator, antiulcer, antioxidant, anticancer, anxiolytic, sedative-hypnotic, and anti-inflammatory activities, among others. The plant has been known to contain phenolic acids, tannins, flavonoids, glycosides, and terpenes. The myrtle oil was also found to be rich in a variety of bioactive monoterpenes and sesquiterpenes with their derivatives. Most of these studies validate the aforementioned traditional claims of this medicinal plant. Further studies are needed to unravel other pharmacological activities of this plant in the long run.

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Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice

Cited by 8 publications

References 23 publications

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Hypnotic effect of the essential oil from the leaves of <em>Myrtus communis</em> on mice

Ethnobotanical, Ethnopharmacological, and Phytochemical Studies of Myrtus communis Linn: A Popular Herb in Unani System of Medicine

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