Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results

Abstract

Dexmedetomidine provided adequate sedation in most of the children aged 1-7 yr without haemodynamic or respiratory effects during MRI procedures.

A prospective randomized double blind study to compare dexmedetomidine and midazolam in ear nose and throat surgery for monitored anesthesia care

“…Koroglu A et al studied and compared the sedative, hemodynamic and respiratory effects of dexmedetomidine with midazolam in children undergoing MRI examination. 8 They found the quality of MRI was significantly better and the rate of adequate sedation was higher in group D than in group M (P<0.001). In group D, the requirement for rescue drugs was lower and the onset of sedation time was shorter than in group M (P<0.001).…”

High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children

“…We and others have examined the role of dexmedetomidine during tonsillectomies in children because it has anxiolytic and analgesic properties that are not associated with respiratory depression. 10,11,[22][23][24] In a study of patients undergoing tonsillectomies, 30 children were randomized to receive a single intraoperative dose of dexmedetomidine 0.5 lgÁkg -1 or morphine 50 lgÁkg -1 . In that study, dexmedetomidine had no opioid sparing effect compared with morphine.…”

Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study

“…9,10 In our study when compared with NS group (Table 2) in dexmedetomidine group the thiopentone requirement was decreased by 50% and intraoperative requirement of morphine by 92.5% and our results were consistent with the earlier studies. [11][12][13][14] Contrary to the previous study, 15 in our study all patients were extubated on the operating table and there was no delayed recovery and also patients who received dexmedetomidine had higher sedation score (Table 3) as assessed by RSS after extubation but all patients had normal and regular respiratory pattern without any airway obst ruct ion and respirat ory depression even though patients had higher sedation scores.…”