Sedative Effects of Hot Flower Infusion of<i>Nyctanthes arbo-tristis</i>. on Rats

Ratnasooriya, W.D.; Jayakody, J. R. A. C.; Hettiarachchi, A.D.I.; Dharmasiri, M.G.

doi:10.1080/13880200590919474

Cited by 21 publications

(20 citation statements)

References 18 publications

(23 reference statements)

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“…Different parts of N. arbor - tristis plants are used in Ayurveda, Siddha-Ayurveda and Unani systems of medicine as a digestives, antidote to reptile venoms, mild bitter tonic, laxative, diaphoretic, diuretic and arthritis [11]. The leaves extract has many proved pharmacological effects like anti-bacterial [10], analgesic, anti-inflammatory [11], anti-diabetic [8, 12], anti-arthritic [13], antioxidant [10], hepatoprotective [14] and antispasmodic activities [12]. Flower extract is also used as a stomachic, carminative, astringent to bowel, antibilious, expectorant, hair tonic and in the treatment of piles and various skin diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice

Rangika

Dayananda

Peiris

2015

BMC Complement Altern Med

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BackgroundBoiled aqueous extract of flowers (AEF) from Nyctanthes arbor-tristis L. are used in Sri Lankan traditional Ayruvedic Medicine to manage diabetes mellitus. AEF has widely been used as a folk medicine for the treatment of various ailments due to its therapeutic activity. However, little is known concerning therapeutic activity of the extract as well as its underline mechanisms and safety. Diabetes is known to increase low-density cholesterol and decrease high-density cholesterol thus triggering coronary diseases. Hence, the primary objective of the present study is to investigate the hypoglycemic and hypolipidemic activities of the AEF.MethodsAEF was prepared and male mice (n = 9 group) were gavaged either with 250, 500 and 750 mg/kg of AEF or distilled water (DW). Subsequently, fasting and random blood glucose concentrations were determined. To investigate mechanisms of actions of AEF, animals were orally administered with 500 mg/kg or the vehicle (DW) and glucose tolerance was performed before and after glucose challenge. For further studies, in vitro alpha-amylase assay and glucose absorption from the gastrointestinal tract were performed using 500 mg/kg of the extract. Additionally, glycogen content in the liver and skeletal muscles, a complete lipid profile assay, and toxicological and biochemical parameters were conducted after a chronic study.ResultsFive hundred mg/kg and 750 mg/kg of AEF significantly (p < 0.01) reduced fasting blood glucose levels respectively by 49 and 39 % at 4 h post-treatment, while 500 mg/kg of AEF also decreased the random blood glucose level significantly (p <0.01) by 32 % at 4 h post-treatment. AEF significantly inhibited glucose absorption by 85 % from the intestine and increased diaphragm uptake of glucose by 64 %. The extract also exhibited inhibition (16.66 %) of alpha-amylase enzyme activity. It also decreased the level of total cholesterol (by 44.8 %), triglyceride (by 53 %) and increased (by 57 %) the high-density lipoprotein cholesterol. Treatment with AEF did not induce any overt signs of toxicity or hepatotoxicity.ConclusionResults the present study indicated that AEF possess hypoglycemic and hypolipdemic properties. Therefore, AEF could be used as an alternative medicine in management of diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice

Rangika

Dayananda

Peiris

2015

BMC Complement Altern Med

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“…Fruits are capsules of 1-2 m in diameter, long and broad, compressed, two celled, separating into two flat one-seeded carpels, reticular veined and glabrous. Leaves are responsible for some CNS activities such as hypnotic, tranquilizing, local anesthetic (Saxena et al 2002;Ratnasooriya et al 2005;Das et al 2008) and antiasthmatic activities (Nirmal et al 2011). Fresh juice of leaves is antimalarial (Badam et al 1988;Aminuddin et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves

Nirmal

Pal²,

Mandal

et al. 2011

Inflammopharmacol

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Nyctanthes arbortristis Linn. (Oleaceae) is one of the well-known Indian medicinal plant. Various extracts of leaves of the plant were screened for analgesic activity by hot plate test and acetic acid-induced writhings and anti-inflammatory activity by carrageenan-induced hind paw edema method at the dose of 50 mg/kg, i.p. Petroleum ether extract was found to be most active and hence subjected to activity-guided fractionation. Results showed that β-sitosterol (5, 10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard extract. β-Sitosterol from N. arbortristis leaves might be responsible for analgesic and anti-inflammatory activity.

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“…Although Sri Lankan Ayurveda system uses the plant for its medicinal applications, the Sepalika plants grown in Sri Lanka were less studied, except for a few work cited in literature (Ratnasooriya and Jayakody, 2004;Ratnasooriya et al, 2005). As the volatile constituents of N. arbortristis flowers grown in Sri Lanka have not been studied the aim of present study is to characterize the volatile constituents of the essential oil and absolute of local N. arbortristis flowers.…”

Section: Introductionmentioning

confidence: 99%

Determination of Volatile Constituents of the Essential Oil and Absolute of Nyctanthes arbortristis L. Flowers Grown in Sri Lanka

Siriwardena¹,

Arambewela²

2014

JTFE

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The volatile constituents of the essential oil and absolute of Nyctanthes arbortristis L. flowers grown in the wet zone of Sri Lanka were investigated in this study. Hydro-distillation and solvent extraction methods were used to obtain the essential oil and the absolute respectively. The volatile samples were analysed by GC-MS techniques. This study led to the identification of 48 chemical constituents of the essential oil and 4 in the absolute. The essential oil composition was dominated by phytol (32.2%) and methyl palmitate (14.7%). Other well-known volatile constituents such as linalool (0.8%), eucarvone (0.9%), phytone (1.4%), nonadecane (2.3%), methyl myristate (1.1%), cis-9-tricosene (3.6%), n-pentacosane (1.6%) and geranylgeraniol (2.7%) were also identified in the essential oil. The absolute was dominated by butyl acetate (80.8%) followed by phenethyl acetate (1.7%), linalool oxide (1.4%) and 2-butoxyethyl acetate (1.4%).

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Sedative Effects of Hot Flower Infusion ofNyctanthes arbo-tristis. on Rats

Cited by 21 publications

References 18 publications

Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice

Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice

Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves

Determination of Volatile Constituents of the Essential Oil and Absolute of Nyctanthes arbortristis L. Flowers Grown in Sri Lanka

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